The DOI matches its OpenAlex record.
Origin of DNA damage in ejaculated human spermatozoa
Open accessAbstract
The molecular basis of many forms of male infertility is poorly defined. One area of research that has been studied intensely is the integrity of the DNA in the nucleus of mature ejaculated spermatozoa. It has been shown that, in men with abnormal sperm parameters, the DNA is more likely to possess strand breaks. However, how and why this DNA damage originates in certain males and how it may influence the genetic project of a mature spermatozoon is unknown. Two theories have been proposed to describe the origin of this DNA damage in mature spermatozoa. The first arises from studies performed in animal models and is linked to the unique manner in which mammalian sperm chromatin is packaged, while the second attributes the nuclear DNA damage in mature spermatozoa to apoptosis. One of the factors implicated in sperm apoptosis is the cell surface protein, Fas. In this review, we discuss the possible origins of DNA damage in ejaculated human spermatozoa, how these spermatozoa arrive in the ejaculate of some men, and what consequences they may have if they succeed in their genetic project.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
EVENSON, D. P., LARSON, K. L., & JOST, L. K. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02599.x · Cited by 1,072
On the possible origins of DNA damage in human spermatozoa
Aitken, R. J., & De Iuliis, G. N. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gap059 · Cited by 606
Saleh, R. A., Agarwal, A., Nada, E. A., El-Tonsy, M. H., Sharma, R. K., Meyer, A., Nelson, D. R., & Thomas, A. J. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00337-6 · Cited by 466
Ollero, M., Gil-Guzman, E., Lopez, M. C., Sharma, R. K., Agarwal, A., Larson, K., Evenson, D., Thomas, A. J., & Alvarez, J. G. (2001) · Human Reproduction · doi:10.1093/humrep/16.9.1912 · Cited by 392
Gil-Guzman, E., Ollero, M., Lopez, M. C., Sharma, R. K., Alvarez, J. G., Thomas, A. J., & Agarwal, A. (2001) · Human Reproduction · doi:10.1093/humrep/16.9.1922 · Cited by 370
Metadata
- Authors
- Sakkas, D.
- Venue
- Reviews of Reproduction
- Publisher
- Bioscientifica
- Published
- 1999-01-01
- Volume
- 4
- Issue
- 1
- Pages
- 31-37
- ISSN
- 1359-6004 (ISSN-L)
- OpenAlex
- W2143468659
- Cited by
- 526
- References
- 0
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Origin of DNA damage in ejaculated human spermatozoa. https://app.cochat.ai/papers/10.1530/revreprod/4.1.31
- The paper
- Sakkas, D. (1999). Origin of DNA damage in ejaculated human spermatozoa. Reviews of Reproduction. https://doi.org/10.1530/revreprod/4.1.31
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
