Cited by 61Cutaneous lymphoproliferative disorders researchNonmelanoma Skin Cancer StudiesSkin Protection and Aging

Extracorporeal photochemoimmunotherapy in cutaneous T-cell lymphoma

Knobler, R., Jantschitsch, C.·2003·Transfusion and Apheresis Science

Abstract

Extracorporeal photochemotherapy was originally conceived for the treatment of cutaneous T-cell lymphoma (CTCL) and as well as other T-cell mediated diseases. Evidence collected in the past 17 years has demonstrated that this treatment modality can have a very significant effect on the course of a subset of CTCL patients. The evidence available is positive but for a variety of reasons has been controversial within the medical community. A number of very well-designed multi-center trials which have been lacking since the first publication by Edelson et al. are being carried out so that hopefully a number of open questions will be resolved with greater clarity in the coming years. The fact remains that this innovative approach for the treatment of CTCL and T-cell mediated diseases has certainly opened new avenues of therapy and thought in photoimmunology and photomedicine. Clearly the very low side effect profile of this therapy has made it more attractive than the chemotherapeutic and immunosuppressive substances that are presently available or in experimental protocols. If and when the mechanisms of action are fully understood and appropriate studies investigating different treatment schedules and different combination therapies and modifications of its present form are performed the place of photopheresis in the therapeutics of CTCL as well as other T-cell mediated diseases and oncology will be better placed.

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Crossref · 10.1016/s1473-0502(02)00103-9

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  • Psoralen derivatives are used in photopheresis of cutaneous T-cell lymphoma and photoinactivation of pathogens in plasma and platelet components.

    “Other applications of psoralen derivatives deal with the photopheresis of cutaneous T-cell lymphoma (156-158) and the photoinactivation of pathogens in plasma and platelet components (159,160).”

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Authors
Knobler, R., & Jantschitsch, C.
Affiliations
University of Vienna (AT)
Corresponding author
Knobler, R.
Venue
Transfusion and Apheresis Science
Publisher
Elsevier BV
Published
2003-02
Volume
28
Issue
1
Pages
81-89
ISSN
1473-0502 (ISSN-L)
OpenAlex
W2115597921
Cited by
61
References
61
Citations by year
2025: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 4
FWCI
0.53
Type
journal article
Language
en
Open access
closed
Locations
  • Transfusion and Apheresis Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Cutaneous lymphoproliferative disorders research
  • Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
extracorporeal photopheresis, cutaneous T-cell lymphoma, T cell-mediated disease, photoimmunology, photomedicine, therapeutic mechanisms, combination therapy, treatment schedule, adverse effects
MeSH terms
Combined Modality Therapy, Humans, Immunity, Cellular, Immunotherapy, Sezary Syndrome, Cytokines, Lymphoma, T-Cell, Cutaneous, Photopheresis

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