The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Effects of chloroquine on viral infections: an old drug against today's diseases
Open accessAbstract
Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication, which are being tested in clinical trials. Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of tumour necrosis factor α and interleukin 6, which mediate the inflammatory complications of several viral diseases. We review the available information on the effects of chloroquine on viral infections, raising the question of whether this old drug may experience a revival in the clinical management of viral diseases such as AIDS and severe acute respiratory syndrome, which afflict mankind in the era of globalisation.
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Cites
Identification of a novel coronavirus in patients with severe acute respiratory syndrome
Drosten, C., Günther, S., Preiser, W., van der Werf, S., Brodt, H.-R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R. A. M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030747 · Cited by 4,574
Weber, S. M., & Levitz, S. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1534 · Cited by 129
Byrd, T. F., & Horwitz, M. A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115301 · Cited by 120
Cited by
Guo (2020) · doi:10.1186/s40779-020-00240-0 · Cited by 4,735
The cytokine storm and COVID-19
Hu, B., Huang, S., & Yin, L. (2021) · Journal of Medical Virology · doi:10.1002/jmv.26232 · Cited by 1,655
Immunology of COVID-19: Current State of the Science
Vabret, N., Britton, G. J., Gruber, C., Hegde, S., Kim, J., Kuksin, M., Levantovsky, R., Malle, L., Moreira, A., Park, M. D., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.002 · Cited by 1,623
Ortiz-Prado, E., Simbaña-Rivera, K., Gómez- Barreno, L., Rubio-Neira, M., Guaman, L. P., Kyriakidis, N. C., Muslin, C., Jaramillo, A. M. G., Barba-Ostria, C., Cevallos-Robalino, D., et al. (2020) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2020.115094 · Cited by 458
Giudicessi, J. R., Noseworthy, P. A., Friedman, P. A., & Ackerman, M. J. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.03.024 · Cited by 394
Metadata
- Authors
- Savarino, A., Boelaert, J. R., Cassone, A., Majori, G., & Cauda, R.
- Venue
- The Lancet Infectious Diseases
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 3
- Issue
- 11
- Pages
- 722-727
- ISSN
- 1473-3099 (ISSN-L)
- OpenAlex
- W2100967823
- Cited by
- 1,268
- References
- 3
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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