Cited by 495Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

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Laboratory diagnosis of invasive aspergillosis

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Hope, WW, Walsh, TJ, Denning, DW·2005·The Lancet Infectious Diseases

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Abstract

Invasive aspergillosis occurs in a wide range of clinical scenarios, is protean in its manifestations, and is still associated with an unacceptably high mortality rate. Early diagnosis is critical to a favourable outcome, but is difficult to achieve with current methods. Deep tissue diagnostic specimens are often difficult to obtain from critically ill patients. Newer antifungal agents exhibit differential mould activity, thus increasing the importance of establishing a specific diagnosis of invasive aspergillosis. For these reasons, a range of alternate diagnostic strategies have been investigated. Most investigative efforts have focused on molecular and serological diagnostic techniques. The detection of metabolites produced by Aspergillus spp and a range of aspergillus-specific antibodies represent additional, but relatively underused, diagnostic avenues. The detection of galactomannan has been incorporated into diagnostic criteria for invasive aspergillosis, reflecting an increased understanding of the performance, utility, and limitations of this technique. Measurement of (1,3)-beta-D glucan in blood may be useful as a preliminary screening tool for invasive aspergillosis, despite the fact that this antigen can be detected in a number of other fungi. There have been extensive efforts directed toward the detection of Aspergillus spp DNA, but a lack of technical standardisation and relatively poor understanding of DNA release and kinetics continues to hamper the broad applicability of this technique. This review considers the application, utility, and limitations of the currently available and investigational diagnostic modalities for invasive aspergillosis.

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Authors: Hope, W., Walsh, T., & Denning, D.
Affiliations: National Institutes of Health (US)
Venue: The Lancet Infectious Diseases
Publisher: Elsevier BV
Published: 2005-10
Volume: 5
Issue: 10
Pages: 609-622
ISSN: 1473-3099 (ISSN-L)
DOI: 10.1016/s1473-3099(05)70238-3
OpenAlex: W2066421491
Cited by: 495
References: 137
Citations by year: 2026: 9 · 2025: 10 · 2024: 12 · 2023: 12 · 2022: 15 · 2021: 13 · 2020: 9 · 2019: 21 · 2018: 15 · 2017: 23 · 2016: 30 · 2015: 36 · 2014: 23 · 2013: 30 · 2012: 33
FWCI: 4.42
Type: journal article
Language: en
Open access: green
research.manchester.ac.uk
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Lancet Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion, other-oa)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: invasive aspergillosis, Aspergillus, laboratory diagnosis, galactomannan, β-1,3-glucan, molecular diagnosis, serological diagnosis, fungal DNA detection, critically ill patients
MeSH terms: Antibodies, Fungal, Aspergillosis, Aspergillus, DNA, Fungal, Galactose, Humans, Mannans, Clinical Laboratory Techniques

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