The DOI matches its Crossref record; 197 of the 198 references it cites were found in a registry or an index.
The role of nasal carriage in Staphylococcus aureus infections
Abstract
Staphylococcus aureus is a frequent cause of infections in both the community and hospital. Worldwide, the increasing resistance of this pathogen to various antibiotics complicates treatment of S aureus infections. Effective measures to prevent S aureus infections are therefore urgently needed. It has been shown that nasal carriers of S aureus have an increased risk of acquiring an infection with this pathogen. The nose is the main ecological niche where S aureus resides in human beings, but the determinants of the carrier state are incompletely understood. Eradication of S aureus from nasal carriers prevents infection in specific patient categories-eg, haemodialysis and general surgery patients. However, recent randomised clinical trials in orthopaedic and non-surgical patients failed to show the efficacy of eliminating S aureus from the nose to prevent subsequent infection. Thus we must elucidate the mechanisms behind S aureus nasal carriage and infection to be able to develop new preventive strategies. We present an overview of the current knowledge of the determinants (both human and bacterial) and risks of S aureus nasal carriage. Studies on the population dynamics of S aureus are also summarised.
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In the citing paper
“bacterial colonization of the URT is generally considered as the first step in the development of invasive bacterial infections (83, 84), including secondary bacterial infections following respiratory viral infection”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [83]
In the citing paper
“S. aureus is transiently carried in the nose of 30% of the population, whilst 20% of the population have persistent nasal colonization (Wertheim et al., 2005).”
From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Wertheim et al., 2005
In the citing paper
“Like H. influenzae and S. pneumoniae, S. aureus is an opportunistic pathogen and a major cause of bacteraemia (Wertheim et al., 2005; Tong et al., 2015).”
From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Wertheim et al., 2005
Citations
Cites
Staphylococcus aureus Infections
Lowy, F. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808203390806 · Cited by 6,018
Wisplinghoff, H., Bischoff, T., Tallent, S. M., Seifert, H., Wenzel, R. P., & Edmond, M. B. (2004) · Clinical Infectious Diseases · doi:10.1086/421946 · Cited by 4,496
Enright, M. C., Day, N., Davies, C. E., Peacock, S. J., & Spratt, B. G. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.3.1008-1015.2000 · Cited by 3,039
Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks
Kluytmans, J., van Belkum, A., & Verbrugh, H. (1997) · Clinical Microbiology Reviews · doi:10.1128/cmr.10.3.505 · Cited by 2,595
Self-citationNasal Carriage as a Source of Staphylococcus aureus Bacteremia
von Eiff, C., Becker, K., Machka, K., Stammer, H., & Peters, G. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101043440102 · Cited by 1,984
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
Whole genome sequencing of meticillin-resistant Staphylococcus aureus
Kuroda, M., Ohta, T., Uchiyama, I., Baba, T., Yuzawa, H., Kobayashi, I., Cui, L., Oguchi, A., Aoki, K.-I., Nagai, Y., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04403-2 · Cited by 1,950
Feil, E. J., Li, B. C., Aanensen, D. M., Hanage, W. P., & Spratt, B. G. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.5.1518-1530.2004 · Cited by 1,861
"Celbenin" - resistant Staphylococci
Jevons, M. P. (1961) · BMJ · doi:10.1136/bmj.1.5219.124-a · Cited by 1,730
Vandenesch, F., Naimi, T. S., Enright, M. C., Lina, G., Nimmo, G. R., Heffernan, H., Liassine, N., Bes, M., Greenland, T., Reverdy, M. E., et al. (2003) · Emerging infectious diseases · doi:10.3201/eid0908.030089 · Cited by 1,718
Research works printed but not linked: 2
- Noble, 1967, Carriage of Staphylococcus aureus in random samples of a normal population, J Hyg (Lond), 65, 567
- Wertheim HFL, Kleef M, Vos MC, Ott A, Verbrugh H, Fokkens W. Nosepicking and nasal carriage of Staphylococcus aureus. Infect Control Hosp Epidemiol (in press).
Cited by
Sorted by citations
Tong, S. Y. C., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler, V. G. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00134-14 · Cited by 5,192
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
Lakhundi, S., & Zhang, K. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00020-18 · Cited by 1,762
Methicillin-resistant Staphylococcus aureus
Lee, A. S., de LENCASTRE, H., Garau, J., Kluytmans, J. A. J. W., Malhotra‐Kumar, S., Peschel, A., & Harbarth, S. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.33 · Cited by 1,691
Pathogenicity and virulence of Staphylococcus aureus
Cheung, G. Y. C., Bae, J. S., & Otto, M. J. (2021) · Virulence · doi:10.1080/21505594.2021.1878688 · Cited by 1,554
Preventing Surgical-Site Infections in Nasal Carriers of Staphylococcus aureus
Bode, L. G. M., Kluytmans, J. A. J. W., Wertheim, H. F. L., Bogaers‐Hofman, D., Vandenbroucke‐Grauls, C. M. J. E., Roosendaal, R., Troelstra, A., Box, A. T. A., Voß, A., van der Tweel, I., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0808939 · Cited by 1,226
Self-citation
Metadata
- Authors
- Wertheim, H. F., Melles, D. C., Vos, M. C., van Leeuwen, W., van Belkum, A., Verbrugh, H. A., & Nouwen, J. L.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Wertheim, Heiman FL
- Venue
- The Lancet Infectious Diseases
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 5
- Issue
- 12
- Pages
- 751-762
- ISSN
- 1473-3099 (ISSN-L)
- OpenAlex
- W2098533519
- Cited by
- 2,685
- References
- 198
- Citations by year
- 2026: 96 · 2025: 138 · 2024: 175 · 2023: 130 · 2022: 146 · 2021: 181 · 2020: 191 · 2019: 161 · 2018: 173 · 2017: 162 · 2016: 145 · 2015: 155 · 2014: 162 · 2013: 155 · 2012: 127
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Nierstichting
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Staphylococcus aureus, nasal carriage, infection control, antibiotic resistance, hemodialysis patients, orthopedic surgery, population dynamics, community-acquired infections, nosocomial infections
- MeSH terms
- Adolescent, Adult, Aged, Carrier State, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Nose, Risk Factors, Staphylococcal Infections, Staphylococcus aureus
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