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Cited by 409

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes

Open access
Halstead, Scott B, Mahalingam, Suresh, Marovich, Mary A, Ubol, Sukathida, Mosser, David M·2010·The Lancet Infectious Diseases
DOI 10.1016/s1473-3099(10)70166-3
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Abstract

A wide range of microorganisms can replicate in macrophages, and cell entry of these pathogens via non-neutralising IgG antibody complexes can result in increased intracellular infection through idiosyncratic Fcγ-receptor signalling. The activation of Fcγ receptors usually leads to phagocytosis. Paradoxically, the ligation of monocyte or macrophage Fcγ receptors by IgG immune complexes, rather than aiding host defences, can suppress innate immunity, increase production of interleukin 10, and bias T-helper-1 (Th1) responses to Th2 responses, leading to increased infectious output by infected cells. This intrinsic antibody-dependent enhancement (ADE) of infection modulates the severity of diseases as disparate as dengue haemorrhagic fever and leishmaniasis. Intrinsic ADE is distinct from extrinsic ADE, whereby complexes of infectious agents with non-neutralising antibodies lead to an increased number of infected cells. Intrinsic ADE might be involved in many protozoan, bacterial, and viral infections. We review insights into intracellular mechanisms and implications of enhanced pathogenesis after ligation of macrophage Fcγ receptors by infectious immune complexes.

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Metadata

Authors
Halstead, S. B., Mahalingam, S., Marovich, M. A., Ubol, S., & Mosser, D. M.
Venue
The Lancet Infectious Diseases
Publisher
Elsevier BV
Published
2010-10
Volume
10
Issue
10
Pages
712-722
ISSN
1473-3099 (ISSN-L)
DOI
10.1016/s1473-3099(10)70166-3
OpenAlex
W2160653307
Cited by
409
References
94
FWCI
19.04
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes. https://app.cochat.ai/papers/10.1016/s1473-3099(10)70166-3
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Halstead, S. B., Mahalingam, S., Marovich, M. A., Ubol, S., & Mosser, D. M. (2010). Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes. The Lancet Infectious Diseases. https://doi.org/10.1016/s1473-3099(10)70166-3

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.