The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Interventions to increase antiretroviral adherence in sub-Saharan Africa: a systematic review of evaluation studies
Open accessAbstract
The success of potent antiretroviral treatment for HIV infection is primarily determined by adherence. We systematically review the evidence of effectiveness of interventions to increase adherence to antiretroviral treatment in sub-Saharan Africa. We identified 27 relevant reports from 26 studies of behavioural, cognitive, biological, structural, and combination interventions done between 2003 and 2010. Despite study diversity and limitations, evidence suggests that treatment supporters, directly observed therapy, mobile-phone text messages, diary cards, and food rations can effectively increase adherence in sub-Saharan Africa. However, some interventions are unlikely to have large or lasting effects, and others are effective only in specific settings. These findings emphasise the need for more research, particularly for randomised controlled trials, to examine the effect of context and specific features of intervention content on effectiveness. Future work should assess intervention targeting and selection of interventions based on behavioural theories relevant to sub-Saharan Africa.
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“A systematic search for mHealth reviews in seven databases found several mHealth reviews that included aspects of monitoring such as adherence studies,17 behaviour change18 and attendance reminders.19 20”
From mHealth text and voice communication for monitoring people with chronic diseases in low-resource settings: a realist review (2018) · cites this paper as [17]
In the citing paper
“and messages had more impact when they were linked with patient–health worker interaction.17 27 49 51–53”
From mHealth text and voice communication for monitoring people with chronic diseases in low-resource settings: a realist review (2018) · cites this paper as [17]
In the citing paper
“For example, weekly reminders worked better than daily reminders”
From mHealth text and voice communication for monitoring people with chronic diseases in low-resource settings: a realist review (2018) · cites this paper as [17]
In the citing paper
“Reviews have found variation in effect depending on how mechanisms were operationalised.”
From mHealth text and voice communication for monitoring people with chronic diseases in low-resource settings: a realist review (2018) · cites this paper as [17]
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Cites
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Cited by
Sorted by citations
The end of AIDS: HIV infection as a chronic disease
Deeks, S. G., Lewin, S. R., & Havlir, D. V. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61809-7 · Cited by 2,081
Increases in Adult Life Expectancy in Rural South Africa: Valuing the Scale-Up of HIV Treatment
Bor, J. H., Herbst, K., Newell, M., & Bärnighausen, T. (2013) · Science · doi:10.1126/science.1230413 · Cited by 579
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“In addition to the historical bias towards enrolment of symptomatic patients, mentioned previously, our mortality estimates do not take into account potential future reductions in mortality that may occur as new drugs and salvage regimens [48] and innovations in patient management are introduced [49].”
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“A number of reviews support the efficacy of behavioral interventions to promote ART adherence [14–16], yet these interventions have diverse approaches and variable financial costs.”
Background
Metadata
- Authors
- Bärnighausen, T., Chaiyachati, K., Chimbindi, N., Peoples, A., Haberer, J., & Newell, M.-L.
- Affiliations
- Harvard University (US)
- University of KwaZulu-Natal (ZA)
- University of Michigan (US)
- Massachusetts General Hospital (US)
- University College London (GB)
- Corresponding author
- Bärnighausen, Till
- ORCID
- Venue
- The Lancet Infectious Diseases
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 11
- Issue
- 12
- Pages
- 942-951
- ISSN
- 1473-3099 (ISSN-L)
- PMC
- PMC4250825
- OpenAlex
- W2098160568
- Cited by
- 246
- References
- 107
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 14 · 2019: 15 · 2018: 19 · 2017: 17 · 2016: 24 · 2015: 29 · 2014: 33 · 2013: 26 · 2012: 29
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust
- U.S. Public Health Service (K-23 087228, 1R01MG083539-01)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD058482, 1R01-HD058482- 01)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Keywords
- antiretroviral therapy adherence, HIV, adherence interventions, treatment supporters, directly observed therapy, text messaging, rations, sub-Saharan Africa, behavioral interventions, intervention effectiveness
- MeSH terms
- Assessment of Medication Adherence, Humans, HIV Infections, Drug Monitoring, Outcome Assessment, Health Care, Africa South of the Sahara, Antiretroviral Therapy, Highly Active, Medication Adherence
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