Cited by 246HIV/AIDS Research and InterventionsMedication Adherence and ComplianceMobile Health and mHealth Applications

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Interventions to increase antiretroviral adherence in sub-Saharan Africa: a systematic review of evaluation studies

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Bärnighausen, Till, Chaiyachati, Krisda, Chimbindi, Natsayi, Peoples, Ashleigh, Haberer, Jessica, Newell, Marie-Louise·2011·The Lancet Infectious Diseases

DOI 10.1016/s1473-3099(11)70181-5PMC PMC4250825

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Abstract

The success of potent antiretroviral treatment for HIV infection is primarily determined by adherence. We systematically review the evidence of effectiveness of interventions to increase adherence to antiretroviral treatment in sub-Saharan Africa. We identified 27 relevant reports from 26 studies of behavioural, cognitive, biological, structural, and combination interventions done between 2003 and 2010. Despite study diversity and limitations, evidence suggests that treatment supporters, directly observed therapy, mobile-phone text messages, diary cards, and food rations can effectively increase adherence in sub-Saharan Africa. However, some interventions are unlikely to have large or lasting effects, and others are effective only in specific settings. These findings emphasise the need for more research, particularly for randomised controlled trials, to examine the effect of context and specific features of intervention content on effectiveness. Future work should assess intervention targeting and selection of interventions based on behavioural theories relevant to sub-Saharan Africa.

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Background

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Authors: Bärnighausen, T., Chaiyachati, K., Chimbindi, N., Peoples, A., Haberer, J., & Newell, M.-L.
Affiliations: Harvard University (US)
University of KwaZulu-Natal (ZA)
University of Michigan (US)
Massachusetts General Hospital (US)
University College London (GB)
Corresponding author: Bärnighausen, Till
ORCID: Bärnighausen, Till
Chaiyachati, Krisda
Chimbindi, Natsayi
Peoples, Ashleigh
Haberer, Jessica
Newell, Marie-Louise
Venue: The Lancet Infectious Diseases
Publisher: Elsevier BV
Published: 2011-12
Volume: 11
Issue: 12
Pages: 942-951
ISSN: 1473-3099 (ISSN-L)
DOI: 10.1016/s1473-3099(11)70181-5
PMC: PMC4250825
OpenAlex: W2098160568
Cited by: 246
References: 107
Citations by year: 2026: 4 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 14 · 2019: 15 · 2018: 19 · 2017: 17 · 2016: 24 · 2015: 29 · 2014: 33 · 2013: 26 · 2012: 29
FWCI: 3.62
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Lancet Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust
U.S. Public Health Service (K-23 087228, 1R01MG083539-01)
National Institute of Child Health and Human Development
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD058482, 1R01-HD058482- 01)
Topics: Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
Keywords: antiretroviral therapy adherence, HIV, adherence interventions, treatment supporters, directly observed therapy, text messaging, rations, sub-Saharan Africa, behavioral interventions, intervention effectiveness
MeSH terms: Assessment of Medication Adherence, Humans, HIV Infections, Drug Monitoring, Outcome Assessment, Health Care, Africa South of the Sahara, Antiretroviral Therapy, Highly Active, Medication Adherence

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Interventions to increase antiretroviral adherence in sub-Saharan Africa: a systematic review of evaluation studies

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