Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy
Abstract
Congenital cytomegalovirus is the most frequent, yet under-recognised, infectious cause of newborn malformation in developed countries. Despite its clinical and public health importance, questions remain regarding the best diagnostic methods for identifying maternal and neonatal infection, and regarding optimal prevention and therapeutic strategies for infected mothers and neonates. The absence of guidelines impairs global efforts to decrease the effect of congenital cytomegalovirus. Data in the literature suggest that congenital cytomegalovirus infection remains a research priority, but data are yet to be translated into clinical practice. An informal International Congenital Cytomegalovirus Recommendations Group was convened in 2015 to address these questions and to provide recommendations for prevention, diagnosis, and treatment. On the basis of consensus discussions and a review of the literature, we do not support universal screening of mothers and the routine use of cytomegalovirus immunoglobulin for prophylaxis or treatment of infected mothers. However, treatment guidelines for infected neonates were recommended. Consideration must be given to universal neonatal screening for cytomegalovirus to facilitate early detection and intervention for sensorineural hearing loss and developmental delay, where appropriate. The group agreed that education and prevention strategies for mothers were beneficial, and that recommendations will need continual updating as further data become available.
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Detection of CMV in the CSF of young infants with suspected sepsis suggests the possibility of congenital CMV infection and the need for additional testing and possibly treatment.
“While detection of CMV may not explain their presentation, it suggests the possibility of congenital CMV infection and the need for additional testing and possibly treatment (27).”
From Retrospective Evaluation of Infants Aged 1 to 60 Days with Residual Cerebrospinal Fluid (CSF) Tested Using the FilmArray Meningitis/Encephalitis (ME) Panel (2018) · cites this paper as [27]
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Flagged first, then by citations
Cited by
Sorted by citations
Blaschke, A. J., Holmberg, K. M., Daly, J. A., Leber, A. L., Dien Bard, J., Korgenski, E. K., Bourzac, K. M., & Kanack, K. J. (2018) · Journal of clinical microbiology · doi:10.1128/jcm.00277-18 · Cited by 57 · see citing works
“While detection of CMV may not explain their presentation, it suggests the possibility of congenital CMV infection and the need for additional testing and possibly treatment (27).”
BackgroundRETRACTED: New intranasal and injectable gene therapy for healthy life extension
Jaijyan, D. K., Selariu, A., Cruz-Cosme, R., Tong, M., Yang, S., Stefa, A., Kekich, D., Sadoshima, J., Herbig, U., Tang, Q., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2121499119 · Cited by 57 · see citing works
Retracted
- Authors
- Rawlinson, W. D., Boppana, S. B., Fowler, K. B., Kimberlin, D. W., Lazzarotto, T., Alain, S., Daly, K., Doutré, S., Gibson, L., Giles, M. L., Greenlee, J., Hamilton, S. T., Harrison, G. J., Hui, L., Jones, C. A., Palasanthiran, P., Schleiss, M. R., Shand, A. W., & van Zuylen, W. J.
- Affiliations
- UNSW Sydney (AU)
- University of Alabama at Birmingham (US)
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Centre Hospitalier Universitaire de Limoges (FR)
- University of Massachusetts Chan Medical School (US)
- Monash University (AU)
- Prince of Wales Hospital (AU)
- Baylor College of Medicine (US)
- The University of Melbourne (AU)
- The University of Sydney (AU)
- University of Minnesota (US)
- Corresponding author
- Rawlinson, William D
- ORCID
- Venue
- The Lancet Infectious Diseases
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 17
- Issue
- 6
- Pages
- e177-e188
- ISSN
- 1473-3099 (ISSN-L)
- OpenAlex
- W2593104383
- Cited by
- 841
- References
- 139
- Citations by year
- 2026: 60 · 2025: 86 · 2024: 109 · 2023: 107 · 2022: 101 · 2021: 104 · 2020: 105 · 2019: 86 · 2018: 54 · 2017: 24
- FWCI
- 57.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Keywords
- congenital cytomegalovirus infection, pregnancy, neonatal infection, maternal infection, prevention, diagnosis, antiviral therapy, universal screening, newborn screening, sensorineural hearing loss, developmental delay, congenital malformations, prevention education
- MeSH terms
- Congenital Abnormalities, Developmental Disabilities, Cytomegalovirus Infections, Cytomegalovirus, Female, Hearing Loss, Sensorineural, Humans, Infant, Newborn, Mothers, Pregnancy, Pregnancy Complications, Infectious, Infectious Disease Transmission, Vertical, Consensus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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