RETRACTED: New intranasal and injectable gene therapy for healthy life extension
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Abstract
As the global elderly population grows, it is socioeconomically and medically critical to provide diverse and effective means of mitigating the impact of aging on human health. Previous studies showed that the adeno-associated virus (AAV) vector induced overexpression of certain proteins, which can suppress or reverse the effects of aging in animal models. In our study, we sought to determine whether the high-capacity cytomegalovirus vector (CMV) can be an effective and safe gene delivery method for two such protective factors: telomerase reverse transcriptase (TERT) and follistatin (FST). We found that the mouse cytomegalovirus (MCMV) carrying exogenous TERT or FST (MCMV TERT or MCMV FST ) extended median lifespan by 41.4% and 32.5%, respectively. We report CMV being used successfully as both an intranasal and injectable gene therapy system to extend longevity. Specifically, this treatment significantly improved glucose tolerance, physical performance, as well as preventing body mass loss and alopecia. Further, telomere shortening associated with aging was ameliorated by TERT and mitochondrial structure deterioration was halted in both treatments. Intranasal and injectable preparations performed equally well in safely and efficiently delivering gene therapy to multiple organs, with long-lasting benefits and without carcinogenicity or unwanted side effects. Translating this research to humans could have significant benefits associated with quality of life and an increased health span.
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An extension of the lifespan is observed when the telomerase reverse transcriptase gene is overexpressed.
“Furthermore, an extension of the lifespan is observed when the telomerase reverse transcriptase (TERT) gene is overexpressed.390”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [390]
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A roadmap to precision treatments for familial pulmonary fibrosis
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Gene therapy strategies for aging intervention
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AgeAnnoMO: a knowledgebase of multi-omics annotation for animal aging
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- Authors
- Jaijyan, D. K., Selariu, A., Cruz-Cosme, R., Tong, M., Yang, S., Stefa, A., Kekich, D., Sadoshima, J., Herbig, U., Tang, Q., Church, G., Parrish, E. L., & Zhu, H.
- Affiliations
- Rutgers New Jersey Medical School (US)
- BioViva USA, Inc.
- Howard University College of Medicine
- Shenzhen University Health Science Center (CN)
- Rutgers Health (US)
- Howard University (US)
- Harvard University (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2022-05-10
- Volume
- 119
- Issue
- 20
- Pages
- e2121499119-e2121499119
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC9171804
- OpenAlex
- W4229445765
- Cited by
- 57
- References
- 76
- Citations by year
- 2026: 2 · 2025: 14 · 2024: 23 · 2023: 11 · 2022: 6 · 2021: 1
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion, cc-by-nc-nd)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- BioViva USA Inc. (000-000-000)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- gene therapy, MCMV, telomerase reverse transcriptase, follistatin, aging, lifespan extension, intranasal gene delivery, telomere shortening, mitochondrial structure, glucose tolerance, hair loss, healthspan
- MeSH terms
- Administration, Inhalation, Animals, Cytomegalovirus Infections, Genetic Vectors, Injections, Intraperitoneal, Life Expectancy, Neoplasms, Genetic Therapy, Telomerase, Models, Animal, Follistatin, Mice
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