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Cited by 1,476

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016

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Troeger, Christopher, Blacker, Brigette F, Khalil, Ibrahim A, Rao, Puja C, Cao, Shujin, Zimsen, Stephanie RM, Albertson, Samuel B, Stanaway, Jeffery D, Deshpande, Aniruddha, Abebe, Zegeye, Alvis-Guzman, Nelson, Amare, Azmeraw T, Asgedom, Solomon W, Anteneh, Zelalem Alamrew, Antonio, Carl Abelardo T, Aremu, Olatunde, Asfaw, Ephrem Tsegay, Atey, Tesfay Mehari, Atique, Suleman, Avokpaho, Euripide Frinel G Arthur, Awasthi, Ashish, Ayele, Henok Tadesse, Barac, Aleksandra, Barreto, Mauricio L, Bassat, Quique, Belay, Saba Abraham, Bensenor, Isabela M, Bhutta, Zulfiqar A, Bijani, Ali, Bizuneh, Hailemichael, Castañeda-Orjuela, Carlos A, Dadi, Abel Fekadu, Dandona, Lalit, Dandona, Rakhi, Do, Huyen Phuc, Dubey, Manisha, Dubljanin, Eleonora, Edessa, Dumessa, Endries, Aman Yesuf, Eshrati, Babak, Farag, Tamer, Feyissa, Garumma Tolu, Foreman, Kyle J, Forouzanfar, Mohammad H, Fullman, Nancy, Gething, Peter W, Gishu, Melkamu Dedefo, Godwin, William W, Gugnani, Harish Chander, Gupta, Rahul, Hailu, Gessessew Bugssa, Hassen, Hamid Yimam, Hibstu, Desalegn Tsegaw, Ilesanmi, Olayinka S, Jonas, Jost B, Kahsay, Amaha, Kang, Gagandeep, Kasaeian, Amir, Khader, Yousef Saleh, Khalil, Ibrahim A, Khan, Ejaz Ahmad, Khan, Muhammad Ali, Khang, Young-Ho, Kissoon, Niranjan, Kochhar, Sonali, Kotloff, Karen L, Koyanagi, Ai, Kumar, G Anil, Magdy Abd El Razek, Hassan, Malekzadeh, Reza, Malta, Deborah Carvalho, Mehata, Suresh, Mendoza, Walter, Mengistu, Desalegn Tadese, Menota, Bereket Gebremichael, Mezgebe, Haftay Berhane, Mlashu, Fitsum Weldegebreal, Murthy, Srinivas, Naik, Gurudatta A, Nguyen, Cuong Tat, Nguyen, Trang Huyen, Ningrum, Dina Nur Anggraini, Ogbo, Felix Akpojene, Olagunju, Andrew Toyin, Paudel, Deepak, Platts-Mills, James A, Qorbani, Mostafa, Rafay, Anwar, Rai, Rajesh Kumar, Rana, Saleem M, Ranabhat, Chhabi Lal, Rasella, Davide, Ray, Sarah E, Reis, Cesar, Renzaho, Andre MN, Rezai, Mohammad Sadegh, Ruhago, George Mugambage, Safiri, Saeid, Salomon, Joshua A, Sanabria, Juan Ramon, Sartorius, Benn, Sawhney, Monika, Sepanlou, Sadaf G, Shigematsu, Mika, Sisay, Mekonnen, Somayaji, Ranjani, Sreeramareddy, Chandrashekhar T, Sykes, Bryan L, Taffere, Getachew Redae, Topor-Madry, Roman, Tran, Bach Xuan, Tuem, Kald Beshir, Ukwaja, Kingsley Nnanna, Vollset, Stein Emil, Walson, Judd L, Weaver, Marcia R, Weldegwergs, Kidu Gidey, Werdecker, Andrea, Workicho, Abdulhalik, Yenesew, Muluken, Yirsaw, Biruck Desalegn, Yonemoto, Naohiro, El Sayed Zaki, Maysaa, Vos, Theo, Lim, Stephen S, Naghavi, Mohsen, Murray, Christopher JL, Mokdad, Ali H, Hay, Simon I, Reiner, Robert C·2018·The Lancet Infectious Diseases
DOI 10.1016/s1473-3099(18)30362-1
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Abstract

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 provides an up-to-date analysis of the burden of diarrhoea in 195 countries. This study assesses cases, deaths, and aetiologies in 1990-2016 and assesses how the burden of diarrhoea has changed in people of all ages. METHODS: We modelled diarrhoea mortality with a Bayesian hierarchical modelling platform that evaluates a wide range of covariates and model types on the basis of vital registration and verbal autopsy data. We modelled diarrhoea incidence with a compartmental meta-regression tool that enforces an association between incidence and prevalence, and relies on scientific literature, population representative surveys, and health-care data. Diarrhoea deaths and episodes were attributed to 13 pathogens by use of a counterfactual population attributable fraction approach. Diarrhoea risk factors are also based on counterfactual estimates of risk exposure and the association between the risk and diarrhoea. Each modelled estimate accounted for uncertainty. FINDINGS: In 2016, diarrhoea was the eighth leading cause of death among all ages (1 655 944 deaths, 95% uncertainty interval [UI] 1 244 073-2 366 552) and the fifth leading cause of death among children younger than 5 years (446 000 deaths, 390 894-504 613). Rotavirus was the leading aetiology for diarrhoea mortality among children younger than 5 years (128 515 deaths, 105 138-155 133) and among all ages (228 047 deaths, 183 526-292 737). Childhood wasting (low weight-for-height score), unsafe water, and unsafe sanitation were the leading risk factors for diarrhoea, responsible for 80·4% (95% UI 68·2-85·0), 72·1% (34·0-91·4), and 56·4% (49·3-62·7) of diarrhoea deaths in children younger than 5 years, respectively. Prevention of wasting in 1762 children (95% UI 1521-2170) could avert one death from diarrhoea. INTERPRETATION: Substantial progress has been made globally in reducing the burden of diarrhoeal diseases, driven by decreases in several primary risk factors. However, this reduction has not been equal across locations, and burden among adults older than 70 years requires attention. FUNDING: Bill & Melinda Gates Foundation.

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Authors
Troeger, C., Blacker, B. F., Khalil, I. A., Rao, P. C., Cao, S., Zimsen, S. R., Albertson, S. B., Stanaway, J. D., Deshpande, A., Abebe, Z., Alvis-Guzman, N., Amare, A. T., Asgedom, S. W., Anteneh, Z. A., Antonio, C. A. T., Aremu, O., Asfaw, E. T., Atey, T. M., Atique, S., Avokpaho, E. F. G. A., Awasthi, A., Ayele, H. T., Barac, A., Barreto, M. L., Bassat, Q., Belay, S. A., Bensenor, I. M., Bhutta, Z. A., Bijani, A., Bizuneh, H., Castañeda-Orjuela, C. A., Dadi, A. F., Dandona, L., Dandona, R., Do, H. P., Dubey, M., Dubljanin, E., Edessa, D., Endries, A. Y., Eshrati, B., Farag, T., Feyissa, G. T., Foreman, K. J., Forouzanfar, M. H., Fullman, N., Gething, P. W., Gishu, M. D., Godwin, W. W., Gugnani, H. C., Gupta, R., Hailu, G. B., Hassen, H. Y., Hibstu, D. T., Ilesanmi, O. S., Jonas, J. B., Kahsay, A., Kang, G., Kasaeian, A., Khader, Y. S., Khalil, I. A., Khan, E. A., Khan, M. A., Khang, Y.-H., Kissoon, N., Kochhar, S., Kotloff, K. L., Koyanagi, A., Kumar, G. A., Magdy Abd El Razek, H., Malekzadeh, R., Malta, D. C., Mehata, S., Mendoza, W., Mengistu, D. T., Menota, B. G., Mezgebe, H. B., Mlashu, F. W., Murthy, S., Naik, G. A., Nguyen, C. T., Nguyen, T. H., Ningrum, D. N. A., Ogbo, F. A., Olagunju, A. T., Paudel, D., Platts-Mills, J. A., Qorbani, M., Rafay, A., Rai, R. K., Rana, S. M., Ranabhat, C. L., Rasella, D., Ray, S. E., Reis, C., Renzaho, A. M., Rezai, M. S., Ruhago, G. M., Safiri, S., Salomon, J. A., Sanabria, J. R., Sartorius, B., Sawhney, M., Sepanlou, S. G., Shigematsu, M., Sisay, M., Somayaji, R., Sreeramareddy, C. T., Sykes, B. L., Taffere, G. R., Topor-Madry, R., Tran, B. X., Tuem, K. B., Ukwaja, K. N., Vollset, S. E., Walson, J. L., Weaver, M. R., Weldegwergs, K. G., Werdecker, A., Workicho, A., Yenesew, M., Yirsaw, B. D., Yonemoto, N., El Sayed Zaki, M., Vos, T., Lim, S. S., Naghavi, M., Murray, C. J., Mokdad, A. H., Hay, S. I., & Reiner, R. C.
Venue
The Lancet Infectious Diseases
Publisher
Elsevier BV
Published
2018-11
Volume
18
Issue
11
Pages
1211-1228
ISSN
1473-3099 (ISSN-L)
DOI
10.1016/s1473-3099(18)30362-1
OpenAlex
W2891808294
Cited by
1,476
References
10
FWCI
86.97
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016. https://app.cochat.ai/papers/10.1016/s1473-3099(18)30362-1
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Troeger, C., Blacker, B. F., Khalil, I. A., Rao, P. C., Cao, S., Zimsen, S. R., Albertson, S. B., Stanaway, J. D., Deshpande, A., Abebe, Z., Alvis-Guzman, N., Amare, A. T., Asgedom, S. W., Anteneh, Z. A., Antonio, C. A. T., Aremu, O., Asfaw, E. T., Atey, T. M., Atique, S., . . . Reiner, R. C. (2018). Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Infectious Diseases. https://doi.org/10.1016/s1473-3099(18)30362-1

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.