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Gluten sensitivity: from gut to brain
Abstract
Gluten sensitivity is a systemic autoimmune disease with diverse manifestations. This disorder is characterised by abnormal immunological responsiveness to ingested gluten in genetically susceptible individuals. Coeliac disease, or gluten-sensitive enteropathy, is only one aspect of a range of possible manifestations of gluten sensitivity. Although neurological manifestations in patients with established coeliac disease have been reported since 1966, it was not until 30 years later that, in some individuals, gluten sensitivity was shown to manifest solely with neurological dysfunction. Furthermore, the concept of extraintestinal presentations without enteropathy has only recently become accepted. In this Personal View, we review the range of neurological manifestations of gluten sensitivity and discuss recent advances in the diagnosis and understanding of the pathophysiological mechanisms underlying neurological dysfunction related to gluten sensitivity.
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“The autoimmune target in neurologic gluten sensitivity is TG6 rather than TG2, which is the target for autoantibodies measured in commercial tests.47”
From The Gut Microbiome and the Brain (2014) · cites this paper as [47]
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Metadata
- Authors
- Hadjivassiliou, M., Sanders, D. S., Grünewald, R. A., Woodroofe, N., Boscolo, S., & Aeschlimann, D.
- Affiliations
- Royal Hallamshire Hospital (GB)
- University of Trieste (IT)
- Cardiff University (GB)
- Corresponding author
- Hadjivassiliou, Marios
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 9
- Issue
- 3
- Pages
- 318-330
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W1992303087
- Cited by
- 404
- References
- 137
- Citations by year
- 2026: 16 · 2025: 18 · 2024: 16 · 2023: 15 · 2022: 15 · 2021: 24 · 2020: 21 · 2019: 21 · 2018: 17 · 2017: 29 · 2016: 23 · 2015: 37 · 2014: 39 · 2013: 30 · 2012: 36
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- SHURA (Sheffield Hallam University Research Archive) (Sheffield Hallam University) (submittedVersion)
- Funders
- Ryder Briggs Neuroscience Research Fund
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- gluten sensitivity, celiac disease, neurological symptoms, autoimmune disease, pathophysiology, diagnosis
- MeSH terms
- Animals, Brain Diseases, Celiac Disease, Gastrointestinal Diseases, Glutens, Humans, Nervous System Diseases, Diet, Gluten-Free
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