The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders
Open accessAbstract
Voltage-gated sodium channels (VGSCs) are key mediators of intrinsic neuronal and muscle excitability. Abnormal VGSC activity is central to the pathophysiology of epileptic seizures, and many of the most widely used antiepileptic drugs, including phenytoin, carbamazepine, and lamotrigine, are inhibitors of VGSC function. These antiepileptic drugs might also be efficacious in the treatment of other nervous system disorders, such as migraine, multiple sclerosis, neurodegenerative diseases, and neuropathic pain. In this Review, we summarise the structure and function of VGSCs and their involvement in the pathophysiology of several neurological disorders. We also describe the biophysical and molecular bases for the mechanisms of action of antiepileptic VGSC blockers and discuss the efficacy of these drugs in the treatment of epileptic and non-epileptic disorders. Overall, clinical and experimental data indicate that these drugs are efficacious for a range of diseases, and that the development of drugs with enhanced selectivity for specific VGSC isoforms might be an effective and novel approach for the treatment of several neurological diseases.
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Cites
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
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De Novo Mutations in the Sodium-Channel Gene SCN1A Cause Severe Myoclonic Epilepsy of Infancy
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Cited by
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel
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Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum
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Self-citationMutations in SCN3A cause early infantile epileptic encephalopathy
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Effects of electromagnetic fields on neuronal ion channels: A systematic review
Bertagna, F., Lewis, R., Silva, S. R. P., McFadden, J., & Jeevaratnam, K. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14597 · Cited by 63
Metadata
- Authors
- Mantegazza, M., Curia, G., Biagini, G., Ragsdale, D. S., & Avoli, M.
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 9
- Issue
- 4
- Pages
- 413-424
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2165232112
- Cited by
- 455
- References
- 106
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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