Moving beyond a categorical diagnosis of autism
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Subtyping cognitive profiles in Autism Spectrum Disorder using a Functional Random Forest algorithm
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“Categorically distinct subtypes are either artificial constructs (Volkmar and McPartland, 2016) or unknown (Constantino and Charman, 2016).”
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“Given environmental interactions with genotype and developmental experience, in all but a subset of cases [14 && ] it may be difficult to extrapolate diagnostic status or developmental course based on genetic markers, suggesting the potential import of intermediary quantifications of the phenotype, such as measures of…”
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“More recently, Volkmar and McPartland (2015) have * Nicci Grace nicci.grace@monash.edu 1 Monash Institute of Cognitive and Clinical Neurosciences, 18 Innovation Walk, Monash University, Clayton, Melbourne, VIC 3800, Australia 2 Deakin Child Study Centre, School of Psychology, Deakin University,…”
BackgroundTrait Autism is a Better Predictor of Empathy than Alexithymia
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“As a matter of fact, ASD is a neurodevelopmental condition characterized by an early onset of persistent social and communication difficulties, in addition to a set of restricted and repetitive patterns of interest and behaviors [23], whose clinical expression can vary deeply depending on the autistic symptoms’ severi…”
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“, 2021), in alignment with a (multi-) dimensional and trait-based approach to ASC (Constantino, 2009; Volkmar and McPartland, 2015; Constantino and Charman, 2016).”
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- Authors
- Volkmar, F. R., & McPartland, J. C.
- Affiliations
- Yale University (US)
- Corresponding author
- Volkmar, Fred R
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 15
- Issue
- 3
- Pages
- 237-238
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W1874154154
- Cited by
- 19
- References
- 10
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 3
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH107426)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, autism diagnosis, disease classification, autistic traits, social communication, early detection, early intervention, personalized medicine, diagnostic thresholds
- MeSH terms
- Autism Spectrum Disorder, Humans, Male
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