The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Effects of Tadalafil on Erectile Dysfunction in Men With Diabetes
Abstract
OBJECTIVE—To evaluate the efficacy and safety of tadalafil taken as needed before sexual activity by men with diabetes and erectile dysfunction (ED). RESEARCH DESIGN AND METHODS—Men with type 1 or type 2 diabetes and a minimum 3-month history of ED were randomly allocated to one of three groups: placebo (n = 71), tadalafil 10 mg (n = 73), or tadalafil 20 mg (n = 72) taken up to once daily for 12 weeks. Changes from baseline in mean scores on the erectile function domain of the International Index of Erectile Function (IIEF) and changes from baseline in the proportion of “yes” responses to question 2, “Were you able to penetrate?,” and 3, “Were you able to complete intercourse?,” of the Sexual Encounter Profile were coprimary outcome measures. RESULTS—A total of 191 (88%) of 216 patients completed the study. Treatment with tadalafil significantly improved all primary efficacy variables, regardless of baseline HbA1c level. Therapy with tadalafil also significantly improved a number of secondary outcome measures, including changes in other IIEF domains, individual IIEF questions, and percentage of positive responses to a global assessment question measuring erection improvement. Treatment with tadalafil did not alter mean HbA1c levels. Tadalafil was well tolerated, with headache and dyspepsia being the most frequent adverse events with active treatment. CONCLUSIONS—Tadalafil therapy significantly enhanced erectile function and was well tolerated by men with diabetes and ED.
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“The GAQ revealed that only 25% of men in the placebo group felt they had improved erections, compared with 56% and 64% of men in the tadalafil 10 mg and 20 mg groups, respectively (p < 0.001) (Sáenz de Tejada et al 2002).”
From Tadalafil in the treatment of erectile dysfunction (2008) · cites this paper as Sáenz de Tejada et al 2002
In the citing paper
“Successful intercourse was improved by 28% and 29% in the two tadalafil groups versus only 1.9% in the placebo group (p < 0.001).”
From Tadalafil in the treatment of erectile dysfunction (2008) · cites this paper as Sáenz de Tejada et al 2002
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“In the largest original, prospective trial of tadalafil in diabetic men, Sáenz de Tejada and co-workers reported that tadalafil significantly improves ED and is well tolerated in this population (Sáenz de Tejada et al 2002).”
From Tadalafil in the treatment of erectile dysfunction (2008) · cites this paper as Sáenz de Tejada et al 2002
In the citing paper
“In diabetic men taking tadalafil 10 mg or 20 mg, the IIEF-EF was improved by 6.4 and 7.3, respectively, compared with 0.1 with placebo (p < 0.001) (Sáenz de Tejada et al 2002).”
From Tadalafil in the treatment of erectile dysfunction (2008) · cites this paper as Sáenz de Tejada et al 2002
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Citations
Cites
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Cited by
Boulton, A. J. M., Vinik, A. I., Arezzo, J. C., Bril, V., Feldman, E. L., Freeman, R., Malik, R. A., Maser, R. E., Sosenko, J. M., & Ziegler, D. (2005) · Diabetes Care · doi:10.2337/diacare.28.4.956 · Cited by 1,859
Tadalafil pharmacokinetics in healthy subjects
Forgue, S. T., Patterson, B. E., Bedding, A. W., Payne, C. D., Phillips, D. L., Wrishko, R. E., & Mitchell, M. I. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2005.02553.x · Cited by 284
Tadalafil in the treatment of erectile dysfunction
Coward, R., & Carson, C. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s3336 · Cited by 138
Tadalafil: a novel treatment for erectile dysfunction
GIULIANO, F. (2002) · European Heart Journal Supplements · doi:10.1016/s1520-765x(02)90049-0 · Cited by 21
Metadata
- Authors
- Sáenz de Tejada, I., Anglin, G., Knight, J. R., & Emmick, J. T.
- Affiliations
- Fundacíon para la Investigacíon y el Desarrollo en Andrología, Madrid, Spain
- Eli Lilly Canada, Toronto, Ontario, Canada
- Eli Lilly and Company, Indianapolis, Indiana
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2002-12-01
- Volume
- 25
- Issue
- 12
- Pages
- 2159-2164
- ISSN
- 0149-5992
- 1935-5548
- Cited by
- 195
- References
- 3
- Language
- en
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