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Induction of functional neovascularization by combined VEGF and angiopoietin-1 gene transfer using AAV vectors

Arsic, Nikola, Zentilin, Lorena, Zacchigna, Serena, Santoro, Daniela, Stanta, Giorgio, Salvi, Alessandro, Sinagra, Gianfranco, Giacca, Mauro·2003·Molecular Therapy
DOI 10.1016/s1525-0016(03)00034-0
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  • Reduced striatal DRD2 was consistently demonstrated in patients and murine models and its dysregulation is a sensitive measure of HD pathology.

    “In fact, reduced striatal DRD2 was consistently demonstrated in patients 45,46,47,48,49 and murine models 27,35,50,51 and its dysregulation is a sensitive measure of HD pathology 37 .”

    From SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington’s disease phenotypes (2021) · cites this paper as [27]

    The Materials and methods and Results passages describe AAV-mediated VEGF and angiopoietin-1 gene transfer in rat muscle, not DRD2 or Huntington’s disease. Searches for striatal DRD2 dysregulation and Huntington’s disease found no passage addressing whether DRD2 is a sensitive measure of HD pathology. Page numbers were not available in our copy. (LLM, conf=0.78)

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  • Steady-state levels of lanosterol, lathosterol, and desmosterol were reduced in the striata of R6/2-Tom mice compared with wt-Tom mice.

    “As expected, the steady-state levels of all cholesterol precursors were reduced in the striata of R6/2-Tom mice compared with wt-Tom mice (Fig. 2H-J) 19,20,27,28 .”

    From SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington’s disease phenotypes (2021) · cites this paper as [27]

  • Similar data were obtained upon cholesterol delivery to the brain of this mouse model via brain-permeable polymeric nanoparticles or mini-pumps.

    “Similar data were obtained upon cholesterol delivery to the brain of this mouse model via brain-permeable polymeric nanoparticles or mini-pumps 27,28 .”

    From SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington’s disease phenotypes (2021) · cites this paper as [27]

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Research works printed but not linked: 38

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  21. Vajanto, 2002, Evaluation of angiogenesis and side effects in ischemic rabbit hindlimbs after intramuscular injection of adenoviral vectors encoding VEGF and LacZ, J. Gene Med., 4, 371, 10.1002/jgm.287 · DOI
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  24. Springer, M. L., et al.2002. Localized arteriolae formation directly adjacent to the site of VEGF delivery in muscle. Molecular Therapy ACCOMPANYING PAPER: EDITOR PLEASE FILL IN
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Metadata

Authors
Arsic, N., Zentilin, L., Zacchigna, S., Santoro, D., Stanta, G., Salvi, A., Sinagra, G., & Giacca, M.
Venue
Molecular Therapy
Publisher
Elsevier BV
Published
2003-04
Volume
7
Issue
4
Pages
450-459
ISSN
1525-0016
DOI
10.1016/s1525-0016(03)00034-0
Cited by
108
References
0
Language
en
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