The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
PEA-15 Mediates Cytoplasmic Sequestration of ERK MAP Kinase
Open accessAbstract
The ERK 1/2 MAP kinase pathway controls cell growth and survival and modulates integrin function. Here, we report that PEA-15, a protein variably expressed in multiple cell types, blocks ERK-dependent transcription and proliferation by binding ERKs and preventing their localization in the nucleus. PEA-15 contains a nuclear export sequence required for its capacity to anchor ERK in the cytoplasm. Genetic deletion of PEA-15 results in increased ERK nuclear localization with consequent increased cFos transcription and cell proliferation. Thus, PEA-15 can redirect the biological outcome of MAP kinase signaling by regulating the subcellular localization of ERK MAP kinase.
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Cites
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Cited by
Differential regulation and properties of MAPKs
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ERK signalling: A master regulator of cell behaviour, life and fate
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The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation
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Metadata
- Authors
- Formstecher, E., Ramos, J. W., Fauquet, M., Calderwood, D. A., Hsieh, J.-C., Canton, B., Nguyen, X.-T., Barnier, J.-V., Camonis, J., Ginsberg, M. H., & Chneiweiss, H.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 1
- Issue
- 2
- Pages
- 239-250
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2158617540
- Cited by
- 313
- References
- 42
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: PEA-15 Mediates Cytoplasmic Sequestration of ERK MAP Kinase. https://app.cochat.ai/papers/10.1016/s1534-5807(01)00035-1
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- Formstecher, E., Ramos, J. W., Fauquet, M., Calderwood, D. A., Hsieh, J.-C., Canton, B., Nguyen, X.-T., Barnier, J.-V., Camonis, J., Ginsberg, M. H., & Chneiweiss, H. (2001). PEA-15 Mediates Cytoplasmic Sequestration of ERK MAP Kinase. Developmental Cell. https://doi.org/10.1016/s1534-5807(01)00035-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
