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Cited by 526Microtubule and mitosis dynamicsCellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Self- and Actin-Templated Assembly of Mammalian Septins

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Kinoshita, Makoto, Field, Christine M., Coughlin, Margaret L., Straight, Aaron F., Mitchison, Timothy J.·2002·Developmental Cell
DOI 10.1016/s1534-5807(02)00366-0
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Abstract

Septins are polymerizing GTPases required for cytokinesis and cortical organization. The principles by which they are targeted to, and assemble at, specific cell regions are unknown. We show that septins in mammalian cells switch between a linear organization along actin bundles and cytoplasmic rings, approximately 0.6 microm in diameter. A recombinant septin complex self-assembles into rings resembling those in cells. Linear organization along actin bundles was reconstituted by adding an adaptor protein, anillin. Perturbation of septin organization in cells by expression of a septin-interacting fragment of anillin or by septin depletion via siRNA causes loss of actin bundles. We conclude that septins alone self-assemble into rings, that adaptor proteins recruit septins to actin bundles, and that septins help organize these bundles.

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Crossref · 10.1016/s1534-5807(02)00366-0

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Research works printed but not linked: 1

  1. Field, 1999, The contractile ring anillin is essential for cell division-associated contractile events in the early Drosophila embryo, Mol. Biol. Cell. Suppl., 10, 239a

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Metadata

Authors
Kinoshita, M., Field, C. M., Coughlin, M. L., Straight, A. F., & Mitchison, T. J.
Affiliations
Harvard University (US)
Corresponding author
Kinoshita, Makoto
ORCID
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2002-12
Volume
3
Issue
6
Pages
791-802
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/s1534-5807(02)00366-0
OpenAlex
W2055376777
Cited by
526
References
36
Citations by year
2026: 13 · 2025: 9 · 2024: 15 · 2023: 14 · 2022: 23 · 2021: 20 · 2020: 26 · 2019: 21 · 2018: 25 · 2017: 17 · 2016: 23 · 2015: 23 · 2014: 24 · 2013: 21 · 2012: 24
FWCI
8.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Developmental Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministério da Educação e Ciência
  • National Institutes of Health (GM23928)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
septins, actin bundles, anillin, septin ring, cytokinesis, cortical organization, GTPase, adaptor proteins, actin cytoskeleton organization, mammalian cells
MeSH terms
Animals, Binding Sites, Blood Proteins, Carrier Proteins, Cell Compartmentation, Contractile Proteins, Cytoskeletal Proteins, Eukaryotic Cells, HeLa Cells, Humans, Luminescent Proteins, Actin Cytoskeleton, Recombinant Fusion Proteins, 3T3 Cells, RNA-Binding Proteins, Protein Structure, Tertiary, GTP-Binding Proteins, GTP Phosphohydrolase Activators, GTP-Binding Protein Regulators, GTP Phosphohydrolases, rho GTP-Binding Proteins, cdc42 GTP-Binding Protein, Adaptor Proteins, Signal Transducing, Green Fluorescent Proteins, Mice, Septins

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