Cited by 526Microtubule and mitosis dynamicsCellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

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Self- and Actin-Templated Assembly of Mammalian Septins

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Kinoshita, Makoto, Field, Christine M., Coughlin, Margaret L., Straight, Aaron F., Mitchison, Timothy J.·2002·Developmental Cell

DOI 10.1016/s1534-5807(02)00366-0

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Abstract

Septins are polymerizing GTPases required for cytokinesis and cortical organization. The principles by which they are targeted to, and assemble at, specific cell regions are unknown. We show that septins in mammalian cells switch between a linear organization along actin bundles and cytoplasmic rings, approximately 0.6 microm in diameter. A recombinant septin complex self-assembles into rings resembling those in cells. Linear organization along actin bundles was reconstituted by adding an adaptor protein, anillin. Perturbation of septin organization in cells by expression of a septin-interacting fragment of anillin or by septin depletion via siRNA causes loss of actin bundles. We conclude that septins alone self-assemble into rings, that adaptor proteins recruit septins to actin bundles, and that septins help organize these bundles.

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Self-citation
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Authors: Kinoshita, M., Field, C. M., Coughlin, M. L., Straight, A. F., & Mitchison, T. J.
Affiliations: Harvard University (US)
Corresponding author: Kinoshita, Makoto
ORCID: Kinoshita, Makoto
Field, Christine M.
Straight, Aaron F.
Venue: Developmental Cell
Publisher: Elsevier BV
Published: 2002-12
Volume: 3
Issue: 6
Pages: 791-802
ISSN: 1534-5807 (ISSN-L)
DOI: 10.1016/s1534-5807(02)00366-0
OpenAlex: W2055376777
Cited by: 526
References: 36
Citations by year: 2026: 13 · 2025: 9 · 2024: 15 · 2023: 14 · 2022: 23 · 2021: 20 · 2020: 26 · 2019: 21 · 2018: 25 · 2017: 17 · 2016: 23 · 2015: 23 · 2014: 24 · 2013: 21 · 2012: 24
FWCI: 8.49
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3881 d)
Locations: Developmental Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Ministério da Educação e Ciência
National Institutes of Health (GM23928)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: septins, actin bundles, anillin, septin ring, cytokinesis, cortical organization, GTPase, adaptor proteins, actin cytoskeleton organization, mammalian cells
MeSH terms: Animals, Binding Sites, Blood Proteins, Carrier Proteins, Cell Compartmentation, Contractile Proteins, Cytoskeletal Proteins, Eukaryotic Cells, HeLa Cells, Humans, Luminescent Proteins, Actin Cytoskeleton, Recombinant Fusion Proteins, 3T3 Cells, RNA-Binding Proteins, Protein Structure, Tertiary, GTP-Binding Proteins, GTP Phosphohydrolase Activators, GTP-Binding Protein Regulators, GTP Phosphohydrolases, rho GTP-Binding Proteins, cdc42 GTP-Binding Protein, Adaptor Proteins, Signal Transducing, Green Fluorescent Proteins, Mice, Septins

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Self- and Actin-Templated Assembly of Mammalian Septins

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