The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR
Open accessAbstract
The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences (IRS) has been thought to be essential for mediating these functions. However, using transcriptional profiling, chromatin immunoprecipitation, and functional experiments, we demonstrate that rather than activation of IRS regulated genes (Class I transcripts), transcriptional repression of D-type cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. These data suggest that a novel mechanism of FKHR-mediated gene regulation is linked to its activity as a suppressor of tumor growth.
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Cited by
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FOXO transcription factors at the interface between longevity and tumor suppression
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FOXOs: signalling integrators for homeostasis maintenance
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The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites
Kaiko, G. E., Ryu, S. H., Koues, O. I., Collins, P. L., Solnica-Krezel, L., Pearce, E. J., Pearce, E. L., Oltz, E. M., & Stappenbeck, T. S. (2016) · Cell · doi:10.1016/j.cell.2016.05.018 · Cited by 733
Metadata
- Authors
- Ramaswamy, S., Nakamura, N., Sansal, I., Bergeron, L., & Sellers, W. R.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 2
- Issue
- 1
- Pages
- 81-91
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2003779663
- Cited by
- 428
- References
- 44
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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