The DOI matches its Crossref record; 115 of the 122 references it cites were found in a registry or an index.
The RB and p53 pathways in cancer
Open accessAbstract
The life history of cancer cells encompasses a series of genetic missteps in which normal cells are progressively transformed into tumor cells that invade surrounding tissues and become malignant. Most prominent among the regulators disrupted in cancer cells are two tumor suppressors, the retinoblastoma protein (RB) and the p53 transcription factor. Here, we discuss interconnecting signaling pathways controlled by RB and p53, attempting to explain their potentially universal involvement in the etiology of cancer. Pinpointing the various ways by which the functions of RB and p53 are subverted in individual tumors should provide a rational basis for developing more refined tumor-specific therapies.
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“p16 is a positive regulator of pRB and tumor suppressor in its own right (Sherr and McCormick, 2002).”
From Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors (2005) · cites this paper as Sherr and McCormick, 2002
Citations
Cites
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Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Cellular senescence: when bad things happen to good cells
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Cell-cycle checkpoints and cancer
Kastan, M. B., & Bartek, J. (2004) · Nature · doi:10.1038/nature03097 · Cited by 2,836
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,379
Malignant astrocytic glioma: genetics, biology, and paths to treatment
Furnari, F. B., Fenton, T., Bachoo, R. M., Mukasa, A., Stommel, J. M., Stegh, A., Hahn, W. C., Ligon, K. L., Louis, D. N., Brennan, C., et al. (2007) · Genes & Development · doi:10.1101/gad.1596707 · Cited by 2,316
Metadata
- Authors
- Sherr, C. J., & McCormick, F.
- Affiliations
- St. Jude Children's Research Hospital (US)
- University of California, San Francisco (US)
- Corresponding author
- Sherr, Charles J
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 2
- Issue
- 2
- Pages
- 103-112
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1992708996
- Cited by
- 1,690
- References
- 122
- Citations by year
- 2026: 31 · 2025: 40 · 2024: 36 · 2023: 60 · 2022: 56 · 2021: 62 · 2020: 62 · 2019: 67 · 2018: 75 · 2017: 67 · 2016: 60 · 2015: 71 · 2014: 88 · 2013: 81 · 2012: 90
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- retinoblastoma protein, p53, tumor suppressor, malignant transformation, signaling pathways, cancer etiology, tumor-specific therapy, oncogenic transformation
- MeSH terms
- Cell Cycle, DNA-Binding Proteins, Humans, Neoplasms, Transcription Factors, Signal Transduction, Tumor Suppressor Protein p53, Retinoblastoma Protein, Apoptosis, Cell Cycle Proteins, Cyclin-Dependent Kinase Inhibitor p16, E2F Transcription Factors
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