Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

Notch Signaling: Cell Fate Control and Signal Integration in Development

Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909

A simplified system for generating recombinant adenoviruses

He, T., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., & Vogelstein, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2509 · Cited by 3,209

Cancer Statistics, 2002

Jemal, A., Thomas, A., Murray, T., & Thun, M. J. (2002) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.52.1.23 · Cited by 2,916

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., et al. (1999) · Nature · doi:10.1038/19083 · Cited by 2,100

Notch signalling controls pancreatic cell differentiation

Apelqvist, Å., Li, H., Sommer, L., Beatus, P., Anderson, D. J., Honjo, T., de Angelis, M. H., Lendahl, U., & Edlund, H. (1999) · Nature · doi:10.1038/23716 · Cited by 1,158

Control of endodermal endocrine development by Hes-1

Jensen, J. N., Pedersen, E. E., Galante, P. E., Hald, J., Heller, R. S., Ishibashi, M., Kageyama, R., Guillemot, F., Serup, P., & Madsen, O. D. (2000) · Nature Genetics · doi:10.1038/71657 · Cited by 1,155

Notch Signaling: From the Outside In

Mumm, J. S., & Kopan, R. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9960 · Cited by 964

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

Dovey, H. F., John, V., Anderson, J. P., Chen, L. Z., Andrieu, P. D. S. I., Fang, L. Y., Freedman, S. B., Folmer, B., Goldbach, E. G., Holsztynska, E. J., et al. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00012.x · Cited by 870

Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

Zulewski, H., Abraham, E. J., Gerlach, M. J., Daniel, P. B., Moritz, W., Müller-Stich, B. P., Vallejo, M., Thomas, M. K., & Habener, J. F. (2001) · Diabetes · doi:10.2337/diabetes.50.3.521 · Cited by 785

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

Sandgren, E. P., Luetteke, N., Palmiter, R. D., Brinster, R. L., & Lee, D. C. (1990) · Cell · doi:10.1016/0092-8674(90)90075-p · Cited by 752

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

Jhappan, C., Stahle, C., Harkins, R. N., Fausto, N., Smith, G. H., & Merlino, G. T. (1990) · Cell · doi:10.1016/0092-8674(90)90076-q · Cited by 709

Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression.

Wilentz, R. E., Iacobuzio–Donahue, C. A., Argani, P., McCarthy, D. M., Parsons, J. L., Yeo, C. J., Kern, S. E., & Hruban, R. H. (2000) · PubMed · Cited by 591

A histone deacetylase corepressor complex regulates the Notch signal transduction pathwayPreprint

Kao, H., Ordentlich, P., Koyano‐Nakagawa, N., Tang, Z., Downes, M., Kintner, C. R., Evans, R. M., & Kadesch, T. R. (1998) · Genes & Development · doi:10.1101/gad.12.15.2269 · Cited by 579

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

Weijzen, S., Rizzo, P., Braid, M., Vaishnav, R., Jonkheer, S. M., Zlobin, A., Osborne, B. A., Gottipati, S., Aster, J. C., Hahn, W. C., et al. (2002) · Nature Medicine · doi:10.1038/nm754 · Cited by 550

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

Jensen, J. N., Heller, R. S., Funder-Nielsen, T., Pedersen, E. E., Lindsell, C. E., Weinmaster, G., Madsen, O. D., & Serup, P. (2000) · Diabetes · doi:10.2337/diabetes.49.2.163 · Cited by 440

Notch signaling induces cell cycle arrest in small cell lung cancer cells.

Sriuranpong, V., Borges, M. W., Ravi, R. K., Arnold, D. R., Nelkin, B. D., Baylin, S. B., & Ball, D. W. (2001) · PubMed · Cited by 435

p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.

Moskaluk, C. A., Hruban, R. H., & Kern, S. E. (1997) · PubMed · Cited by 429

Induction of Cyclin D1 Transcription and CDK2 Activity by Notch ic : Implication for Cell Cycle Disruption in Transformation by Notch ic

Ronchini, C., & Capobianco, A. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5925-5934.2001 · Cited by 418

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

Finch, P. W., He, X., Kelley, M. J., Üren, A., Schaudies, R. P., Popescu, N. C., Rudikoff, S., Aaronson, S. A., VARMUS, H. E., & Rubin, J. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6770 · Cited by 417

Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning

Davis, R. L., & Turner, D. L. (2001) · Oncogene · doi:10.1038/sj.onc.1205094 · Cited by 392

Constitutive activation of NF‐κB and T‐cell leukemia/lymphoma in Notch3 transgenic mice

Bellavia, D., Campese, A. F., Alesse, E., Vacca, A., Felli, M. P., Balestri, A., Stoppacciaro, A., Tiveron, C., Tatangelo, L., Giovarelli, M., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.13.3337 · Cited by 363

Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate

Esler, W. P., Kimberly, W. T., Ostaszewski, B. L., Ye, W., Diehl, T. S., Selkoe, D. J., & Wolfe, M. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052436599 · Cited by 343

Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-κB and PPARγ

Nickoloff, B. J., Qin, J.-Z., Chaturvedi, V., Denning, M. F., Bonish, B. K., & Miele, L. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401036 · Cited by 330

Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.

Chen, H., Thiagalingam, A., Chopra, H., Borges, M., Feder, J. N., Nelkin, B., Baylin, S., & Ball, D. W. (1997) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.94.10.5355 · Cited by 310

Nestin-EGFP Transgenic Mice: Visualization of the Self-Renewal and Multipotency of CNS Stem Cells

Kawaguchi, A., Miyata, T., Sawamoto, K., Takashita, N., Murayama, A. Y., Akamatsu, W., Ogawa, M., Okabe, M., Tano, Y., Goldman, S. A., et al. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0925 · Cited by 307

Discovery of Novel Tumor Markers of Pancreatic Cancer using Global Gene Expression Technology

Iacobuzio–Donahue, C. A., Maitra, A., Shen-Ong, G. L. C., van Heek, N. T., Ashfaq, R., Meyer, R., Walter, K., Berg, K. D., Hollingsworth, M. A., Cameron, J. L., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62551-5 · Cited by 294

Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease

Wolfe, M. S., Xia, W., Moore, C. L., Leatherwood, D. D., Ostaszewski, B., Rahmati, T., Donkor, I. O., & Selkoe, D. J. (1999) · Biochemistry · doi:10.1021/bi982562p · Cited by 289

NF-κB2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jκ

Oswald, F., Liptay, S., Adler, G., & Schmid, R. M. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.2077 · Cited by 269

Notch1 is required for neuronal and glial differentiation in the cerebellum

Lütolf, S., Radtke, F., Aguet, M., Suter, U., & Taylor, V. (2002) · Development · doi:10.1242/dev.129.2.373 · Cited by 264

Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis.

Gansauge, S., Gansauge, F., Ramadani, M., Stobbe, H., Rau, B., Harada, N., & Beger, H. G. (1997) · PubMed · Cited by 261

Notch Inhibition of RAS Signaling Through MAP Kinase Phosphatase LIP-1 During C. elegans Vulval Development

Berset, T., Fröhli, E., Battu, G., Canevascini, S., & Hajnal, A. (2001) · Science · doi:10.1126/science.1055642 · Cited by 257

Role of Growth Factors in Pancreatic Cancer

Korc, M. (1998) · Surgical Oncology Clinics of North America · doi:10.1016/s1055-3207(18)30283-7 · Cited by 234

Neoplastic Transformation by Truncated Alleles of Human NOTCH1/TAN1 and NOTCH2

Capobianco, A. J., Zagouras, P., Blaumueller, C. M., Artavanis‐Tsakonas, S., & Bishop, J. M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6265 · Cited by 230

Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin

Arlt, A., Vorndamm, J., Breitenbroich, M., Fölsch, U. R., Kalthoff, H., Schmidt, W. E., & Schäfer, H. (2001) · Oncogene · doi:10.1038/sj.onc.1204168 · Cited by 227

Notch-1 Regulates NF-κB Activity in Hemopoietic Progenitor Cells

Cheng, P., Zlobin, A., Volgina, V. V., Gottipati, S., Osborne, B. A., Simel, E. J., Miele, L., & Gabrilovich, D. I. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.8.4458 · Cited by 216

Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter

Lechner, A., Leech, C. A., Abraham, E. J., Nolan, A. L., & Habener, J. F. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00275-9 · Cited by 210

Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor α

Song, S. Y., GANNON, M. A., Washington, M. K., Scoggins, C. R., Meszoely, I. M., Goldenring, J. R., Marino, C. R., Sandgren, E. P., Coffey, R. J., Wright, C. V. E., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70292-1 · Cited by 205

A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human diseasePreprint

Wagner, M., Greten, F. R., Weber, C. K., Koschnick, S., Mattfeldt, T., Deppert, W., Kern, H. F., Adler, G., & Schmid, R. M. (2001) · Genes & Development · doi:10.1101/gad.184701 · Cited by 204

Malignant transformation of duct-like cells originating from acini in transforming growth factor α transgenic mice

WAGNER, M., Lührs, H., Klöppel, G., Adler, G., & Schmid, R. M. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70098-8 · Cited by 193

HERP, a New Primary Target of Notch Regulated by Ligand Binding

Iso, T., Sartorelli, V., Chung, G., Shichinohe, T., Kedes, L., & Hamamori, Y. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.6071-6079.2001 · Cited by 191

Coexpression of Nestin in Neural and Glial Cells in the Developing Human CNS Defined by a Human-Specific Anti-nestin Antibody

Messam, C. A., Hou, J., & Major, E. O. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7319 · Cited by 182

Exploring the Host Desmoplastic Response to Pancreatic Carcinoma

Iacobuzio–Donahue, C. A., Ryu, B., Hruban, R. H., & Kern, S. E. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64353-2 · Cited by 178

Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas

Selander, L., & Edlund, H. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00023-0 · Cited by 171

Nestin-Expressing Cells in the Pancreatic Islets of Langerhans

Hunziker, E., & Stein, M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2611 · Cited by 160

Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch‐DSL signaling system during brain development

Irvin, D. K., Zurcher, S. D., Nguyen, T., Weinmaster, G., & Kornblum, H. I. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1059 · Cited by 155

Ras pathway signals are required for notch-mediated oncogenesis

Fitzgerald, K. J., Harrington, A. N., & Leder, P. (2000) · Oncogene · doi:10.1038/sj.onc.1203766 · Cited by 147

Notch signaling in T cell development

Deftos, M. L., & Bevan, M. J. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00067-9 · Cited by 140

Reciprocal Regulatory Interactions between the Notch and Ras Signaling Pathways in the Drosophila Embryonic Mesoderm

Carmena, A., Buff, E. M., Halfon, M. S., Gisselbrecht, S. S., Jiménez, F., Baylies, M. K., & Michelson, A. M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0606 · Cited by 136

Delta/Notch and Boss/Sevenless Signals Act Combinatorially to Specify the Drosophila R7 Photoreceptor

Tomlinson, A., & Struhl, G. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00196-4 · Cited by 123

Aspartate Mutations in Presenilin and γ‐Secretase Inhibitors Both Impair Notch1 Proteolysis and Nuclear Translocation with Relative Preservation of Notch1 Signaling

Berezovska, O., Jack, C. E., McLean, P. J., Aster, J. C., Hicks, C. D., Xia, W., Wolfe, M. S., Kimberly, W. T., Weinmaster, G., Selkoe, D. J., et al. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750583.x · Cited by 118

HERP1 Is a Cell Type-specific Primary Target of Notch

Iso, T., Chung, G., Hamamori, Y., & Kedes, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110495200 · Cited by 107

Ductal metaplasia of human exocrine pancreas and its association with carcinoma.

Parsa, I., Longnecker, D. S., Scarpelli, D. G., Pour, P. M., Reddy, J. K., & Lefkowitz, M. (1985) · PubMed · Cited by 103

The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning

Culí, J., Martı́n-Blanco, E., & Modolell, J. (2001) · Development · doi:10.1242/dev.128.2.299 · Cited by 100

Antagonism of EGFR and Notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors

Lage, P. Z., & Jarman, A. P. (1999) · Development · doi:10.1242/dev.126.14.3149 · Cited by 78

Pathology of incipient pancreatic cancer

Hruban, R. H., Wilentz, R. E., Goggins, M., Offerhaus, G. J. A., Yeo, C. J., & Kern, S. E. (1999) · Annals of Oncology · doi:10.1093/annonc/10.suppl_4.s9 · Cited by 76

Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans

Grant, B. D., & Greenwald, I. (1997) · Development · doi:10.1242/dev.124.3.637 · Cited by 70

Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells

Wagner, M., Weber, C. K., Bressau, F., Greten, F. R., Stagge, V., Ebert, M. P., Leach, S. D., Adler, G., & Schmid, R. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.33594 · Cited by 65

Fritz: a secreted frizzled-related protein that inhibits Wnt activity

Mayr, T., Deutsch, U., Kühl, M., Drexler, H. C. A., Lottspeich, F., Deutzmann, R., Wedlich, D., & Risau, W. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00035-x · Cited by 63

Dominant Enhancers of Egfr in Drosophila melanogaster: Genetic Links Between the Notch and Egfr Signaling Pathways

Price, J. V., Savenye, E. D., Lum, D. H., & Breitkreutz, A. (1997) · Genetics · doi:10.1093/genetics/147.3.1139 · Cited by 60

Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene

Donoviel, D. B., Donoviel, M. S., Fan, E. Y., Hadjantonakis, A., & Bernstein, A. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00146-4 · Cited by 52

Complete cDNA sequence and genomic organization of a human pancreas-specific gene homologous to Caenorhabditis elegans sel-1

Harada, Y., Ozaki, K., Suzuki, M., Fujiwara, T., Takahashi, E., Nakamura, Y., & Tanigami, A. (1999) · Journal of Human Genetics · doi:10.1007/s100380050171 · Cited by 38

The Importance of the Centroacinar Region in Cerulein-Induced Mouse Pancreatic Growth

Gasslander, T., Ihse, I., & Smeds, S. (1992) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529209000120 · Cited by 30

Regional differences in the cellular proliferation activity of the regenerating rat pancreas after partial pancreatectomy.

Hayashi, K., TAKAHASHI, T., Kakita, A., & Yamashina, S. (1999) · Archivum histologicum japonicum · doi:10.1679/aohc.62.337 · Cited by 28

Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma

Hu, Y.-X., Watanabe, H., Ohtsubo, K., Yamaguchi, Y., Ha, A., Motoo, Y., Okai, T., & Sawabu, N. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690466 · Cited by 23

Notch-1 expression levels in 3T3-L1 cells influence ras signaling and transformation by oncogenic ras.

Ruiz‐Hidalgo, M. J., Garcés, C., & Laborda, J. (1999) · International Journal of Oncology · doi:10.3892/ijo.14.4.777 · Cited by 10

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471

Genetics and biology of pancreatic ductal adenocarcinomaPreprint

Hezel, A. F., Kimmelman, A. C., Stanger, B. Z., Bardeesy, N. M., & DePinho, R. A. (2006) · Genes & Development · doi:10.1101/gad.1415606 · Cited by 1,611

Pancreatic cancer: Advances and challenges

Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321

Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice

Guerra, C., Schuhmacher, A. J., Cañamero, M., Grippo, P. J., Verdaguer, L., Pérez-Gallego, L., Dubus, P., Sandgren, E. P., & Barbacid, M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.012 · Cited by 1,224

Expression profiling identifies microRNA signature in pancreatic cancer

Lee, E. J., Gusev, Y., Jiang, J., Nuovo, G. J., Lerner, M. R., Frankel, W. L., Morgan, D. L., Postier, R. G., Brackett, D. J., & Schmittgen, T. D. (2006) · International Journal of Cancer · doi:10.1002/ijc.22394 · Cited by 909

Primers on Molecular Pathways — Notch

Lomberk, G. A., & Urrutia, R. A. (2008) · Pancreatology · doi:10.1159/000123603 · Cited by 12

Progress in Role of Notch Signaling Pathway in Pancreas Development and Pancreatic Cancer

Yu-pe, Z. (2010) · Zhongguo pu-wai jichu yu linchuang zazhi

Notch signaling pathway in pancreatic tumorigenesis

Chung, W.-C., & Xu, K. (2023) · Advances in cancer research · doi:10.1016/bs.acr.2023.02.001 · Cited by 11

Epithelial differentiation in pancreatic development and neoplasia: new niches for nestin and Notch.

Leach, S. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000155547.83901.a3 · Cited by 43

Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer

Zhang, S.-Y., Chung, W.-C., & Xu, K. (2015) · Oncogene · doi:10.1038/onc.2015.306 · Cited by 41