Schmid, Roland M.

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis

Bollrath, J., Phesse, T. J., von Burstin, V. A., Putoczki, T., Bennecke, M., Bateman, T., Nebelsiek, T., Lundgren-May, T., Canli, Ö., Schwitalla, S., et al. (2009) · Cancer Cell

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

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Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer

Lesina, M., Kurkowski, M. U., Ludes, K., Rose-John, S., Treiber, M., Klöppel, G., Yoshimura, A., Reindl, W., Sipos, B., Akira, S., et al. (2011) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchCytokine Signaling Pathways and Interactions

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Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B

Wahl, C., Liptay, S., Adler, G., & Schmid, R. M. (1998) · Journal of Clinical Investigation

NF-κB Signaling PathwaysNatural Compounds in Disease Treatment

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Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

Miyamoto, Y., Maitra, A., Ghosh, B., Zechner, U., Argani, P., Iacobuzio-Donahue, C. A., Sriuranpong, V., Iso, T., Meszoely, I. M., Wolfe, M. S., et al. (2003) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchDevelopmental Biology and Gene Regulation

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NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

Greten, F. R., Arkan, M. C., Bollrath, J., Hsu, L.-C., Goode, J., Miething, C., Göktuna, S. I., Neuenhahn, M., Fierer, J., Paxian, S., et al. (2007) · Cell

NF-κB Signaling PathwaysInflammasome and immune disorders

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Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase

Ruess, D. A., Heynen, G. J., Ciecielski, K. J., Ai, J., Berninger, A., Kabacaoglu, D., Görgülü, K., Dantes, Z., Wörmann, S. M., Diakopoulos, K. N., et al. (2018) · Nature Medicine

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

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Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer

Eser, S., Reiff, N., Messer, M., Seidler, B., Gottschalk, K., Dobler, M., Hieber, M., Arbeiter, A., Klein, S., Kong, B., et al. (2013) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling

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NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer

Grinberg-Bleyer, Y., Oh, H., Desrichard, A., Bhatt, D. M., Caron, R., Chan, T. A., Schmid, R. M., Klein, U., Hayden, M. S., & Ghosh, S. (2017) · Cell

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

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Notch Signaling Is Required for Exocrine Regeneration After Acute Pancreatitis

Siveke, J. T., Lubeseder–Martellato, C., Lee, M., Mazur, P. K., Nakhai, H., Radtke, F., & Schmid, R. M. (2008) · Gastroenterology

Pancreatitis Pathology and TreatmentPancreatic function and diabetes

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Lineage fate of ductular reactions in liver injury and carcinogenesis

Jörs, S., Jeliazkova, P., Ringelhan, M., Thalhammer, J., Dürl, S., Ferrer, J., Sander, M., Heikenwalder, M., Schmid, R. M., Siveke, J. T., et al. (2015) · Journal of Clinical Investigation

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

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Cross talk between stimulated NF-κB and the tumor suppressor p53

Schneider, G., Henrich, A., Greiner, G., Wolf, V, Lovas, A., Wieczorek, M., Wagner, T., Reichardt, S., von Werder, A., Schmid, R. M., et al. (2010) · Oncogene

NF-κB Signaling PathwaysCancer-related Molecular Pathways

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Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice

Quinton, L. J., Blahna, M. T., Jones, M. R., Allen, E., Ferrari, J. D., Hilliard, K. L., Zhang, X., Sabharwal, V., Algül, H., Akira, S., et al. (2012) · Journal of Clinical Investigation

NF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions

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A machine learning model for the prediction of survival and tumor subtype in pancreatic ductal adenocarcinoma from preoperative diffusion-weighted imaging

Kaissis, G., Ziegelmayer, S., Lohöfer, F., Algül, H., Eiber, M., Weichert, W., Schmid, R., Friess, H., Rummeny, E., Ankerst, D., et al. (2019) · European Radiology Experimental

Radiomics and Machine Learning in Medical ImagingMRI in cancer diagnosis

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A machine learning algorithm predicts molecular subtypes in pancreatic ductal adenocarcinoma with differential response to gemcitabine-based versus FOLFIRINOX chemotherapy

Kaissis, G., Ziegelmayer, S., Lohöfer, F., Steiger, K., Algül, H., Muckenhuber, A., Yen, H.-Y., Rummeny, E., Friess, H., Schmid, R., et al. (2019) · PLOS ONE

Radiomics and Machine Learning in Medical ImagingPancreatic and Hepatic Oncology Research

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Rbpj expression in regulatory T cells is critical for restraining TH2 responses

Delacher, M., Schmidl, C., Herzig, Y., Breloer, M., Hartmann, W., Brunk, F., Kägebein, D., Träger, U., Hofer, A.-C., Bittner, S., et al. (2019) · Nature Communications

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

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Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death

Conradt, L., Henrich, A., Wirth, M., Reichert, M., Lesina, M., Algül, H., Schmid, R. M., Krämer, O. H., Saur, D., & Schneider, G. (2013) · International Journal of Cancer

Cancer-related Molecular PathwaysPancreatic and Hepatic Oncology Research

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Accurate prediction of histological grading of intraductal papillary mucinous neoplasia using deep learning

Schulz, D., Heilmaier, M., Phillip, V., Treiber, M., Mayr, U., Lahmer, T., Mueller, J., Demir, I. E., Friess, H., Reichert, M., et al. (2023) · Endoscopy

AI in cancer detectionPancreatic and Hepatic Oncology Research

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