The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Oct-3/4 is a dose-dependent oncogenic fate determinant
Open accessAbstract
The Oct-3/4 transcription factor sustains embryonic stem (ES) cell self-renewal and is a dose-dependent cell fate determinant. In the adult male, its expression is restricted to type A spermatogonia. We show that Oct-3/4 is expressed in all human testicular germ cell tumors (GCTs) tested, even in the early premalignant component. We demonstrate that Oct-3/4 dictates ES cells' oncogenic potential in a dose-dependent manner; high levels increase the malignant potential of ES cell-derived tumors while Oct-3/4 inactivation induces regression of the malignant component. Oct-3/4 expression in a heterologous cell system transforms nontumorigenic cells and endows tumorigenicity in nude mice. Our findings suggest that Oct-3/4 is not only a distinctive immunohistochemical marker for GCTs, but also plays a critical role in the genesis of these tumors.
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Cites
Stem cells, cancer, and cancer stem cells
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The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
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A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo
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Essential role for oncogenic Ras in tumour maintenance
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Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells
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Cited by
Hypoxia-Inducible Factors, Stem Cells, and Cancer
Keith, B., & Simon, M. C. (2007) · Cell · doi:10.1016/j.cell.2007.04.019 · Cited by 1,179
Testicular germ-cell tumours in a broader perspective
Oosterhuis, J. W., & Looijenga, L. H. J. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1568 · Cited by 916
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
Feinberg, A. P., Koldobskiy, M. A., & Göndör, A. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.13 · Cited by 841
HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity
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Hochedlinger, K., Yamada, Y., Beard, C., & Jaenisch, R. (2005) · Cell · doi:10.1016/j.cell.2005.02.018 · Cited by 747
Metadata
- Authors
- Gidekel, S., Pizov, G., Bergman, Y., & Pikarsky, E.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 4
- Issue
- 5
- Pages
- 361-370
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2078448971
- Cited by
- 441
- References
- 47
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gidekel, S., Pizov, G., Bergman, Y., & Pikarsky, E. (2003). Oct-3/4 is a dose-dependent oncogenic fate determinant. Cancer Cell. https://doi.org/10.1016/s1535-6108(03)00270-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
