The DOI matches its Crossref record.
In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 52
- Alessi, 1996, Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase, FEBS Lett., 399, 333, 10.1016/S0014-5793(96)01370-1 · DOI · Paper page
- Arion, 1988, Cdc 2 is a component of the M-phase specific histone H1 kinase, Cell, 55, 371, 10.1016/0092-8674(88)90060-8 · DOI · Paper page
- Artega, 1989, Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor, Cancer Res., 49, 6237
- Azzi, 1992, Interaction between the cell cycle control protein p34cdc2 and p9CKShs, Eur. J. Biochem., 203, 353, 10.1111/j.1432-1033.1992.tb16557.x · doi:10.1111/j.1432-1033.1992.tb16557.x
- Baserga, 2000, The contradictions of the insulin-like growth factor 1 receptor, Oncogene, 19, 5574, 10.1038/sj.onc.1203854 · DOI · Paper page
- Bazzoni, 1996, Bcr/Abl expression stimulates integrin function in hematopoietic cell lines, J. Clin. Invest., 98, 521, 10.1172/JCI118820 · DOI
- Bhat, 1997, Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells, J. Biol. Chem., 272, 16170, 10.1074/jbc.272.26.16170 · DOI
- Burfeind, 1996, Antisense RNA to the type I insulin-like growth factor receptor suppresses tumour growth and prevents invasion by rat prostate cancer cells in vivo, Proc. Natl. Acad. Sci. USA, 93, 7263, 10.1073/pnas.93.14.7263 · DOI · Paper page
- Chernicky, 2000, Treatment of human breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor inhibits cell growth, suppresses tumourogenesis, alters the metastatic potential and prolongs survival in vivo, Cancer Gene Ther., 7, 384, 10.1038/sj.cgt.7700126 · doi:10.1038/sj.cgt.7700126
- Coppola, 1994, A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor, Mol. Cell. Biol., 14, 4588, 10.1128/MCB.14.7.4588 · DOI · Paper page
- D'Ambrosio, 1996, A soluble Insulin-like growth factor I receptor that induces apoptosis of tumour cells in vivo and inhibits tumourogenesis, Cancer Res., 56, 4013
- De Angelis, 1995, R. Insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the platelet-derived growth factor receptor, J. Cell. Physiol., 164, 214, 10.1002/jcp.1041640126 · doi:10.1002/jcp.1041640126
- De Leon, 1992, Effects of insulin-like growth factors (IGFs) and IGF receptor antibodies on the proliferation of human breast cancer cells, Growth Factors, 6, 327, 10.3109/08977199209021544 · doi:10.3109/08977199209021544
- Dunn, 1998, A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion and metastasis of breast cancer, Cancer Res., 58, 3353
- Freedman, 1974, Cellular tumourigenicity in nude mice, Cell, 3, 355, 10.1016/0092-8674(74)90050-6 · DOI · Paper page
- Fürstenberger, 2002, Insulin-like growth factors and cancer, Lancet Oncol., 3, 298, 10.1016/S1470-2045(02)00731-3 · DOI · Paper page
- Geiges, 1997, Activation of PKC subtypes α,γ,δ,ϵ,ζ and η by tumour promoting and non-tumour promoting agents, Biochem. Pharmacol., 53, 865, 10.1016/S0006-2952(96)00885-4 · DOI
- Grimberg, 2000, Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis, J. Cell. Physiol., 183, 1, 10.1002/(SICI)1097-4652(200004)183:1<1::AID-JCP1>3.0.CO;2-J · DOI · Paper page
- Kalebic, 1998, Expression of a kinase deficient IGF-IR suppresses tumourogenicity of rhabdomyosarcoma cells constitutively expressing a wild-type IGF-IR, Int. J. Cancer, 76, 223, 10.1002/(SICI)1097-0215(19980413)76:2<223::AID-IJC9>3.0.CO;2-Z · doi:10.1002/(sici)1097-0215(19980413)76:2<223::aid-ijc9>3.0.co;2-z
- Kaleko, 1990, Overexpression of the human insulin-like growth factor I receptor promotes ligand dependent neoplastic transformation, Mol. Cell. Biol., 10, 464, 10.1128/MCB.10.2.464 · DOI · Paper page
- Kato, 1993, Role of tyrosine kinase activity in signal transduction by the insulin-like growth factors (IGF-I) receptor, J. Biol. Chem., 268, 2655, 10.1016/S0021-9258(18)53824-2 · DOI · Paper page
- Khandwala, 2000, The effects of insulin-like growth factors on tumourogenesis and neoplastic growth, Endocr. Rev., 21, 215, 10.1210/edrv.21.3.0399 · DOI · Paper page
- Li, 2000, Activation of insulin-like growth factor I receptor signaling pathway is critical for mouse plasma cell tumour growth, Cancer Res., 60, 3909
- Long, 1995, Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to insulin-like growth factor receptor, Cancer Res., 55, 1006
- Lopez, 2002, Elevated levels of the IGF-I receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumourogenesis, Cancer Cell, 1, 339, 10.1016/S1535-6108(02)00055-7 · DOI · Paper page
- McGlynn, 1992, Large scale purification and characterization of a recombinant epidermal growth factor receptor protein tyrosine kinase, Eur. J. Biochem., 207, 265, 10.1111/j.1432-1033.1992.tb17047.x · DOI
- Mitsiades, 2004, Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors, Cancer Cell, 5, 221, 10.1016/S1535-6108(04)00050-9 · DOI · Paper page
- Meijer, 1989, Cyclin is a component of the sea urchin egg M-Phase specific histone H1 kinase, EMBO J., 8, 2275, 10.1002/j.1460-2075.1989.tb08353.x · DOI · Paper page
- Meijer, 1991, Cyclin B targets p34cdc2 for tyrosine phosphorylation, EMBO J., 8, 2275, 10.1002/j.1460-2075.1989.tb08353.x · DOI · Paper page
- Nakamura, 2000, Down-regulation of the insulin-like growth factor I receptor by antisense RNA can reverse the transformed phenotype of human cervical cancer cell lines, Cancer Res., 60, 760
- Prager, 1994, Dominant negative inhibition of tumourogenesis in vivo by human insulin-like growth factor I receptor mutant, Proc. Natl. Acad. Sci. USA, 91, 2181, 10.1073/pnas.91.6.2181 · doi:10.1073/pnas.91.6.2181
- Pronk, 1994, Involvement of Shc in Insulin- and Epidermal Growth Factor-induced activation of p21ras, Mol. Cell. Biol., 14, 1575, 10.1128/MCB.14.3.1575 · DOI
- Resnicoff, 1994, Growth inhibition of human melanoma cells in nude mice by antisense strategies to type 1 insulin-like growth factor receptor, Cancer Res., 54, 4848
- Resnicoff, 1995, Correlation between apoptosis, tumourogenesis and the levels of insulin-like growth factor I receptor, Cancer Res., 55, 3739
- Reiss, 1998, Inhibition of tumour growth by a dominant negative mutant of the insulin-like growth factor I receptor with a bystander effect, Clin. Cancer Res., 4, 2647
- Rialet, 1991, A new screening test for antimitotic compounds using universal M phase-specific protein kinase, p34cdc2/cyclin Bcdc13, affinity-immobilized on p13suc1-coated microtitration plates, Anticancer Res., 11, 1581
- Samani, 2001, Inhibition of carcinoma cell growth and metastasis by a vesicular stomatitis virus G-pseudotyped retrovector expressing type I insulin-like growth factor receptor antisense, Hum. Gene Ther., 12, 1969, 10.1089/104303401753204544 · doi:10.1089/104303401753204544
- Scotlandi, 1998, Blockage of insulin-like growth factor I receptor inhibits the growth of Ewing's sarcoma in athymic mice, Cancer Res., 58, 4127
- Scotlandi, 2002, Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumourogenesis and enhances chemosensitivity in Ewing's sarcoma cells, Int. J. Cancer, 101, 11, 10.1002/ijc.10537 · DOI
- Scotlandi, 2002, Effectiveness of insulin-like growth factor I receptor antisense strategy againstEwing's sarcoma cells, Cancer Gene Ther., 9, 296, 10.1038/sj.cgt.7700442 · DOI
- Sell, 1993, Simian virus 40 large tumour antigen is unable to transform mouse embryonic fibroblasts lacking type I Insulin-like growth factor receptor, Proc. Natl. Acad. Sci. USA, 90, 11217, 10.1073/pnas.90.23.11217 · DOI · Paper page
- Sell, 1994, Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts, Mol. Cell. Biol., 14, 3604, 10.1128/MCB.14.6.3604 · DOI · Paper page
- Shapiro, 1994, Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma, J. Clin. Invest., 94, 1235, 10.1172/JCI117441 · doi:10.1172/jci117441
- Stabel, 1991, Expression of protein kinase C isotypes in baculovirus vectors, Methods Enzymol., 200, 670, 10.1016/0076-6879(91)00179-Z · doi:10.1016/0076-6879(91)00179-z
- Stiles, 1979, Dual control of cell growth by somatomedins and platelet-derived growth factor, Proc. Natl. Acad. Sci. USA, 76, 1279, 10.1073/pnas.76.3.1279 · DOI · Paper page
- Ullrich, 1990, Signal transduction by receptors tyrosine kinase activity, Cell, 61, 203, 10.1016/0092-8674(90)90801-K · DOI · Paper page
- Valentinis, 1997, Insulin-like growth factor I receptor signaling in transformation by Src oncogenes, Mol. Cell. Biol., 17, 3744, 10.1128/MCB.17.7.3744 · DOI
- Van der Geer, 1994, Receptor protein-tyrosine kinases and their signal transduction pathways, Annu. Rev. Cell Biol., 10, 251, 10.1146/annurev.cellbio.10.1.251 · DOI
- Wang, 2002, Insulin-like growth factor receptor-1 as an anti-cancer target, Curr. Cancer Drug Targets, 2, 191, 10.2174/1568009023333863 · DOI
- White, 2000, Antisense inhibition of IGF-I receptor expression in HaCaT keratinocytes, Antisense Nucleic Acid Drug Dev., 10, 195, 10.1089/oli.1.2000.10.195 · doi:10.1089/oli.1.2000.10.195
- Williams, 1992, Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase, Proc. Natl. Acad. Sci. USA, 89, 2922, 10.1073/pnas.89.7.2922 · DOI
- Yu, 2000, Role of the insulin-like growth factor family in cancer development and progression, J. Natl. Cancer Inst., 92, 1472, 10.1093/jnci/92.18.1472 · DOI · Paper page
Cited by
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
Sharma, S. V., Lee, D. Y., Li, B., Quinlan, M. P., Takahashi, F., Maheswaran, S., McDermott, U., Azizian, N., Zou, L., Fischbach, M. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.02.027 · Cited by 2,770
mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt
O'Reilly, K. E., Rojo, F., She, Q.-B., Solit, D., Mills, G. B., Smith, D., Lane, H., Hofmann, F., Hicklin, D. J., Ludwig, D. L., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2925 · Cited by 2,561
Self-citationMaira, S.-M., Stauffer, F., Brueggen, J., Furet, P., Schnell, C., Fritsch, C., Brachmann, S., Chène, P., De Pover, A., Schoemaker, K., et al. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0017 · Cited by 1,134
Self-citationThe insulin and insulin-like growth factor receptor family in neoplasia: an update
Pollak, M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3215 · Cited by 1,116
Corcoran, R. B., Ebi, H., Turke, A. B., Coffee, E. M., Nishino, M., Cogdill, A. P., Brown, R. D., Della Pelle, P., Dias-Santagata, D., Hung, K. E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0341 · Cited by 1,022
Metadata
- Authors
- Garcı́a-Echeverrı́a, C., Pearson, M. A., Marti, A., Meyer, T., Mestan, J., Zimmermann, J., Gao, J., Brueggen, J., Capraro, H.-G., Cozens, R., Evans, D. B., Fabbro, D., Furet, P., Porta, D. G., Liebetanz, J., Martiny-Baron, G., Ruetz, S., & Hofmann, F.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 5
- Issue
- 3
- Pages
- 231-239
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1999030960
- Cited by
- 542
- References
- 0
- FWCI
- 28.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3425 d)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase. https://app.cochat.ai/papers/10.1016/s1535-6108(04)00051-0
- The paper
- Garcı́a-Echeverrı́a, C., Pearson, M. A., Marti, A., Meyer, T., Mestan, J., Zimmermann, J., Gao, J., Brueggen, J., Capraro, H.-G., Cozens, R., Evans, D. B., Fabbro, D., Furet, P., Porta, D. G., Liebetanz, J., Martiny-Baron, G., Ruetz, S., & Hofmann, F. (2004). In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. https://doi.org/10.1016/s1535-6108(04)00051-0
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.