The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint
Open accessAbstract
Chronic myelogeneous leukemia (CML) is a two-stage disease associated with expression of the BCR/ABL tyrosine kinase protein. However, whether BCR/ABL expression directly causes blast crisis, and if so by what mechanism, is unknown. We have found that BCR/ABL translocates from the cytoplasm to the nucleus after genotoxic stress. Furthermore, BCR/ABL increases DNA double-strand damage after etoposide treatment and leads to a defect in an intra-S phase checkpoint, causing a radioresistant DNA synthesis (RDS) phenotype. In the nucleus, BCR/ABL associates with the ataxia-telangiectasia and rad 3-related protein (ATR) and disrupts ATR-dependent signal transduction. Overexpression of ATR in a BCR/ABL-expressing cell line corrects the DNA damage phenotype. These results demonstrate a nuclear role for BCR/ABL in altering the cellular response to DNA damage.
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“The oncogenic BCR-ABL fusion protein disrupts ATR-dependent intra-S phase checkpoint in chronic myeloid leukemia after etoposide treatment, by causing DNA strand break formation [33].”
From The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia (2017) · cites this paper as [33]
Citations
Cites
A simple technique for quantitation of low levels of DNA damage in individual cells
Singh, N. P., McCoy, M. T., Tice, R. R., & Schneider, E. L. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90265-0 · Cited by 10,828
Druker, B. J., Talpaz, M., Resta, D. J., Peng, B., Buchdunger, E., Ford, J., Lydon, N., Kantarjian, H. M., Capdeville, R., Ohno-Jones, S., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104053441401 · Cited by 5,237
Daley, G. Q., Etten, R. A. V., & Baltimore, D. (1990) · Science · doi:10.1126/science.2406902 · Cited by 2,141
Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966
Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
Gong, J., Costanzo, A., Yang, H., Melino, G., Kaelin, W. G., Levrero, M., & Wang, J. Y. J. (1999) · Nature · doi:10.1038/21690 · Cited by 923
Konopka, J. B., Watanabe, S. M., & Witte, O. N. (1984) · Cell · doi:10.1016/0092-8674(84)90438-0 · Cited by 872
Radiosensitivity in ataxia-telangiectasia: a new explanation.
Painter, R. B., & Young, B. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7315 · Cited by 795
Pear, W. S., Miller, J. P., Xu, L., Pui, J. C., Soffer, B., Quackenbush, R. C., Pendergast, A. M., Bronson, R. T., Aster, J. C., Scott, M. L., et al. (1998) · Blood · doi:10.1182/blood.v92.10.3780 · Cited by 761
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Items 101–116 of 116
Effects of The BCR-ABLl Oncogene on DNA Damage and Repair
Burke, B. A. (2010) · ScholarlyCommons (University of Pennsylvania)
Wang, L., O’Leary, H. A., & Gibson, L. F. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0711-0_18
Smith, B. D., & Cho, E. (2012) · Wiley eBooks · doi:10.1002/9781118464557.ch42
Aspectos moleculares da transformação celular induzida por Bcr-Abl.
da Silva, A. E. B. B. (2008) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2008.tde-03062008-153936
ATR (ataxia telangiectasia and Rad3 related)
Gagou, M., & Meuth, M. (2011) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/44954
Skorta, I. (2009) · OPUS Publication Server of the University of Stuttgart (University of Stuttgart) · doi:10.18419/opus-1857
Gold, D. A. (2009) · CaltechTHESIS (California Institute of Technology) · doi:10.7907/xg90-5475
Zhang, H. (2012) · Digital Commons-TMC (Texas Medical Center)
Clustering GO Terms Applied to Differential Gene Expression Detection
Li, L. (2011) · Chinese Journal of Appplied Environmental Biology · doi:10.3724/sp.j.1145.2011.00422
Chau, J. F. L., & Li, B. (2015) · Apple Academic Press eBooks · doi:10.1201/b18597-4
Lin, H. (2017) · cIRcle (University of British Columbia) · doi:10.14288/1.0306413
Overview of the DNA Damage Checkpoint
Dupré, A., & Gautier, J. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-221-2_11
Angelova, R., Momekov, G., & Stavrakov, G. (2026) · Pharmacia · doi:10.3897/pharmacia.73.e190815
DNA Repair Mechanisms in Other Cancer Stem Cell Models
Kai, M. (2012) · Springer eBooks · doi:10.1007/978-94-007-4590-2_7
Proteomic analysis of leukaemogenic protein tyrosine kinase action
Griaud, F. (2012) · Research Explorer (The University of Manchester)
Metadata
- Authors
- Dierov, J., Dierova, R., & Carroll, M.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Carroll, Martin
- ORCID
- Carroll, Martin
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 5
- Issue
- 3
- Pages
- 275-285
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2035713316
- Cited by
- 117
- References
- 40
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 4 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 9
- FWCI
- 7.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Chronic Myeloid Leukemia Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- BCR-ABL, chronic myeloid leukemia, nuclear translocation, ATR, S-phase checkpoint, DNA damage response, radioresistant DNA synthesis, etoposide, DNA double-strand breaks, blast crisis, tyrosine kinase
- MeSH terms
- Cell Nucleus, Cells, Cultured, Cytoplasm, DNA Damage, DNA Topoisomerases, Type II, DNA Repair, Enzyme Inhibitors, Etoposide, Humans, Signal Transduction, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Fusion Proteins, bcr-abl, S Phase, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Protein Transport, Ataxia Telangiectasia Mutated Proteins
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