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Guo, Z., Kumagai, A., Wang, S. X., & Dunphy, W. G. (2000) · Genes &amp; Development · doi:10.1101/gad.842500 · Cited by 417 · see citing works

Recombinational DNA repair and human disease

Thompson, L. H., & Schild, D. (2002) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(02)00224-5 · Cited by 417 · see citing works

ATR phosphorylates SMARCAL1 to prevent replication fork collapsePreprint

Couch, F. B., Bansbach, C. E., Driscoll, R., Luzwick, J. W., Glick, G. G., Betous, R., Carroll, C. M., Jung, S. Y., Qin, J., Cimprich, K. A., et al. (2013) · Genes & Development · doi:10.1101/gad.214080.113 · Cited by 409 · see citing works

DNA repair mechanisms in cancer development and therapy

Torgovnick, A., & Schumacher, B. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00157 · Cited by 403 · see citing works

Targeting the checkpoint kinases: chemosensitization versus chemoprotection

Zhou, B. S., & Bártek, J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1296 · Cited by 390 · see citing works

The G2-phase DNA-damage checkpoint

O’Connell, M. J., Walworth, N. C., & Carr, A. M. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01773-6 · Cited by 385 · see citing works

ATR and ATM regulate the timing of DNA replication origin firing

Shechter, D., Costanzo, V., & Gautier, J. (2004) · Nature Cell Biology · doi:10.1038/ncb1145 · Cited by 383 · see citing works

ATR/CHK1 inhibitors and cancer therapy

Qiu, Z., Oleinick, N. L., & Zhang, J. (2017) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2017.09.043 · Cited by 378 · see citing works

TopBP1 activates ATR through ATRIP and a PIKK regulatory domainPreprint

Mordes, D. A., Glick, G. G., Zhao, R., & Cortez, D. (2008) · Genes & Development · doi:10.1101/gad.1666208 · Cited by 368 · see citing works

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357 · see citing works

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

Murga, M., Bunting, S. F., Montaña, M. F., Soria, R., Mulero, F., Cañamero, M., Lee, Y., McKinnon, P. J., Nussenzweig, A., & Fernández-Capetillo, Ó. (2009) · Nature Genetics · doi:10.1038/ng.420 · Cited by 351 · see citing works

DNA-Damage Response in Tissue-Specific and Cancer Stem Cells

Blanpain, C., Mohrin, M., Sotiropoulou, P. A., & Passegue, E. A. (2011) · Cell stem cell · doi:10.1016/j.stem.2010.12.012 · Cited by 350 · see citing works

Loss of the Forkhead Transcription Factor FoxM1 Causes Centrosome Amplification and Mitotic Catastrophe

Wonsey, D. R., & Follettie, M. T. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4059 · Cited by 346 · see citing works

RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression

Rezatabar, S., Karimian, A., Rameshknia, V., Parsian, H., Majidinia, M., Kopi, T. A., Bishayee, A., Sadeghinia, A., Yousefi, M., Monirialamdari, M., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28334 · Cited by 343 · see citing works

Targeting ATR in cancer

Lecona, E., & Fernández-Capetillo, Ó. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0034-3 · Cited by 327 · see citing works

DNA repair deficiency and neurological disease

McKinnon, P. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2559 · Cited by 323 · see citing works

DNA damage checkpoint kinases in cancer

Smith, H. L., Southgate, H. E. D., Tweddle, D. A., & Curtin, N. J. (2020) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2020.3 · Cited by 323 · see citing works

Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae

Myung, K., Datta, A., & Kolodner, R. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00227-6 · Cited by 322 · see citing works

Hypoxia Links ATR and p53 through Replication Arrest

Hammond, E. M., Denko, N. C., Dorie, M. J., Abraham, R. T., & Giaccia, A. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1834-1843.2002 · Cited by 321 · see citing works

Activation of mammalian Chk1 during DNA replication arrest

Feijóo, C. G., Hall-Jackson, C. A., Wu, R., Jenkins, D., Leitch, J., Gilbert, D. M., & Smythe, C. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200104099 · Cited by 318 · see citing works

Checkpoint kinase 1 in DNA damage response and cell cycle regulation

Patil, M., Pabla, N., & Dong, Z. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1307-3 · Cited by 317 · see citing works

Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase

Buisson, R., Boisvert, J. L., Benes, C. H., & Zou, L. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.029 · Cited by 316 · see citing works

ATR signalling: more than meeting at the fork

Nam, E. A., & Cortez, D. (2011) · Biochemical Journal · doi:10.1042/bj20102162 · Cited by 316 · see citing works

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

Sørensen, C. S., & Syljuåsen, R. G. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr697 · Cited by 316 · see citing works

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

Kabeche, L., Nguyen, H. D., Buisson, R., & Zou, L. (2017) · Science · doi:10.1126/science.aan6490 · Cited by 303 · see citing works

The combined status of ATM and p53 link tumor development with therapeutic responsePreprint

Jiang, H., Reinhardt, H. C., Bártková, J., Tommiska, J., BLOMQVIST, C. P., Nevanlinna, H. A., Bártek, J., Yaffe, M. B., & Hemann, M. T. (2009) · Genes & Development · doi:10.1101/gad.1815309 · Cited by 303 · see citing works

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing Radiation

Gatei, M. H., Sloper, K., Sørensen, C. S., Syljuåsen, R. G., Falck, J., Hobson, K., Savage, K. I., Lukas, J., Zhou, B.-B., Bártek, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210862200 · Cited by 300 · see citing works

Repair of and checkpoint response to topoisomerase I-mediated DNA damage

Pommier, Y. G., Redon, C., Rao, V. A., Seiler, J. A., Sordet, O., Takemura, H., Antony, S., Meng, L., Liao, Z., Kohlhagen, G., et al. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.016 · Cited by 299 · see citing works

An intrinsic S/G 2 checkpoint enforced by ATR

Saldivar, J. C., Hamperl, S., Bocek, M. J., Chung, M., Bass, T. E., Cisneros-Soberanis, F., Samejima, K., Xie, L., Paulson, J. R., Earnshaw, W. C., et al. (2018) · Science · doi:10.1126/science.aap9346 · Cited by 299 · see citing works

Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA -Mutant Ovarian Cancer Models

Kim, H., George, E. M., Ragland, R. L., Rafail, S., Zhang, R., Krepler, C., Morgan, M. A., Herlyn, M., Brown, E. J., & Simpkins, F. A. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2273 · Cited by 294 · see citing works

CENTROSOMES IN CELLULAR REGULATION

Doxsey, S., McCollum, D., & Theurkauf, W. E. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.120418 · Cited by 293 · see citing works

ATR: a master conductor of cellular responses to DNA replication stress

Flynn, R. L., & Zou, L. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.09.005 · Cited by 290 · see citing works

ATR inhibition selectively sensitizes G ₁ checkpoint-deficient cells to lethal premature chromatin condensation

Nghiem, P., Park, P. K., Kim, Y.-S., Vaziri, C., & Schreiber, S. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161281798 · Cited by 290 · see citing works

Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis

Adachi, S., Minamisawa, K., Okushima, Y., Inagaki, S., Yoshiyama, K., Kondou, Y., Kaminuma, E., Kawashima, M., Toyoda, T., Matsui, M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103584108 · Cited by 289 · see citing works

ATR Regulates a G2-Phase Cell-Cycle Checkpoint in Arabidopsis thaliana

Culligan, K. M., Tissier, A. F., & Britt, A. (2004) · The Plant Cell · doi:10.1105/tpc.018903 · Cited by 284 · see citing works

ATR/ATM Targets Are Phosphorylated by ATR in Response to Hypoxia and ATM in Response to Reoxygenation

Hammond, E. M., Dorie, M. J., & Giaccia, A. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212360200 · Cited by 282 · see citing works

ATR autophosphorylation as a molecular switch for checkpoint activation

Liu, S., Shiotani, B., Lahiri, M., Maréchal, A., Tse, A., Leung, C. C. Y., Glover, J. N. M., Yang, X. H., & Zou, L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.019 · Cited by 281 · see citing works

The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage

Zhao, X., Chabes, A., Domkin, V., Thelander, L., & Rothstein, R. J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.13.3544 · Cited by 281 · see citing works

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

de Klein, A., Muijtjens, M., van Os, R. P., Verhoeven, Y., Smit, B., Carr, A. M., Lehmann, A. R., & Hoeijmakers, J. H. J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00447-4 · Cited by 437 · see citing works

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

Yamamoto, K., Wang, Y., Jiang, W., Liu, X., Dubois, R. L., Lin, C., Ludwig, T., Bakkenist, C. J., & Zha, S. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201204098 · Cited by 113 · see citing works

Analysis of Cell Cycle Progression and Genomic Integrity in Early Lethal Knockouts

Brown, E. J. (2004) · Humana Press eBooks · doi:10.1385/1-59259-788-2:201 · Cited by 9 · see citing works

p53-Independent Apoptosis Disrupts Early Organogenesis in Embryos Lacking Both Ataxia-Telangiectasia Mutated and Prkdc

Gladdy, R. A., Nutter, L. M. J., Kunath, T., Danska, J. S., & Guidos, C. J. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0258 · Cited by 17 · see citing works

Exploration of Ataxia Telangiectasia and Rad3-Related’s (ATR’s) Role in Cell Death Regulation: Implications in Development, Cancer, and Stroke

Cartwright, B. M. (2019) · Digital Commons - East Tennessee State University (East Tennessee State University)