Is there a relationship between obstructive sleep apnea and gastroesophageal reflux disease?
Open accessAbstract
Background and aims The causative relationship between obstructive sleep apnea (OSA) and gastroesophageal reflux disease (GERD) remains an area of controversy. The aim of the study is to further explore the relationship between OSA and GERD in a large group of patients with OSA.Methods One hundred thirty-six patients referred for polysomnographic studies at the University of Arizona Sleep Center were included in this study. All patients were assessed by means of a demographic survey, the validated GERD Symptom Checklist, and the Sleep Heart Health Study Sleep Habits Questionnaire. Polysomnograms were scored for objective measures of sleep and breathing. OSA is defined as an apnea-hypopnea index > 5 with compatible symptoms.Results Of the 136 subjects, 101 (74%) were found to have OSA. Self-report of heartburn or acid regurgitation symptoms was unrelated to severity of sleep apnea. Additionally, OSA was not influenced by the severity of GERD. Objective measures of disordered sleep had stronger associations with age, smoking, and alcohol use than GERD in men and stronger associations with age and body mass index than GERD in women. Subjectively reported sleep quality was affected more strongly by GERD severity than by age, smoking, alcohol use, or the presence of OSA. Only females administered antireflux medications were less likely to report poor sleep quality.Conclusions Subjective reports of sleep quality were affected by GERD severity, but an objective correlation between OSA and GERD was lacking. This may suggest that GERD and OSA are common entities that share similar risk factors, but appear not to be causally linked.
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Numerous studies have established a high incidence of gastroesophageal reflux disease among patients with sleep-disordered breathing.
“Numerous studies have established a high incidence of GERD among patients with SDB.923–936”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [931]
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Laryngopharyngeal Reflux and Obstructive Sleep Apnea Syndrome
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Editor's Corner: IAOM's 40th Anniversary, and Sleep Posture
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- Authors
- Morse, C. A., Quan, S. F., Mays, M. Z., Green, C., Stephen, G., & Fass, R.
- Affiliations
- Southern Arizona VA Health Care System (US)
- University of Arizona (US)
- Corresponding author
- Fass, Ronnie
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 2
- Issue
- 9
- Pages
- 761-768
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2049677526
- Cited by
- 95
- References
- 37
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 8 · 2015: 4 · 2014: 7 · 2013: 5 · 2012: 4
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- obstructive sleep apnea, gastroesophageal reflux disease, heartburn, acid regurgitation, sleep quality, apnea-hypopnea index, risk factors, sex differences, antireflux medication, smoking, alcohol consumption, body mass index
- MeSH terms
- Adult, Female, Gastroesophageal Reflux, Humans, Male, Middle Aged, Monitoring, Physiologic, Surveys and Questionnaires, Risk Factors, Severity of Illness Index, Sex Factors, Sleep, Body Mass Index, Polysomnography, Sleep Apnea, Obstructive
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