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The presentation of irritable bowel syndrome in the context of somatization disorder
Open accessAbstract
Background and aims Somatization disorder, a female predominant disorder, has been found with higher than expected prevalence in previous studies of irritable bowel syndrome (IBS) and might be responsible for some of the comorbidity and excessive health care resource use associated with IBS. The study's aim was to determine within a female IBS population the degree of segregation of psychiatric illness, functional disorders, and health care utilization with somatization disorder. Methods In a prospective, 6-month follow-up study, psychiatric disorders were assessed with the Diagnostic Interview Schedule, gastrointestinal and other symptoms with self-report questionnaires, and medically unexplained complaints by thorough chart review. The setting was a university gastroenterology clinic. The participants were a convenience sample of female clinic attendees with IBS (N = 56). Results Somatization disorder was diagnosed in 25% of patients and highly probable in another 5%. Somatization disorder was associated with significantly greater numbers of gastrointestinal and other symptoms, psychiatric disorders, physicians consulted, telephone calls to physicians, urgent care visits, medication changes, and missed work days and with benzodiazepine use. On follow-up, somatization disorder was associated with psychiatric and IBS symptoms, medication changes, and treatment dissatisfaction. Both somatization disorder and other psychiatric illnesses were associated with other functional gastrointestinal disorders; only somatization disorder remained predictive in a regression model that controlled for the presence of other psychiatric illness. Conclusions Among female IBS patients attending a university gastroenterology clinic, many aspects of comorbidity and health care behaviors previously associated with IBS segregated with the diagnosis of somatization disorder. Recognition and appreciation of somatization disorder in IBS have important ramifications for the conduct of research and clinical practice.
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“The various functional disorders have important characteristics in common, including epidemiology (female predominance), pathophysiology (inflammation, hypersensitivity, impaired central processing of afferent sensory information, role of serotonin, psychological distress and somatization, and the role of stress and life events), diagnosis (symptom-based), the central role of the patient-physician”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [8]
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“Still, as discussed above, SD is a potentially important link between the various functional disorders.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [8]
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“In fact SD was much more important that depression or anxiety, which are often considered as psychiatric associates of IBS.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [8]
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“They reported that many aspects of co-morbidity and health care behaviors were more associated with the diagnosis of SD than with the diagnosis of IBS.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [8]
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“North et al.8 reported a very high rate of non-gastrointestinal functional disorders in IBS patients, but significantly more so among those with SD.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [8]
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Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,842
The american college of rheumatology 1990 criteria for the classification of fibromyalgia
Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563
The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
Fukuda, K., Straus, S. E., Hickie, I., Sharpe, M. C., Dobbins, J. G., Komaroff, A., & and International Chronic Fatigue Syndrome Study Group. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00009 · Cited by 4,969
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116
A Comparison of Clinical and Diagnostic Interview Schedule Diagnoses
Helzer, J. E. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790300019003 · Cited by 621
Boyd, J. H. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790210065008 · Cited by 543
Chaudhary, N. A., & Truelove, S. C. (1962) · QJM · doi:10.1093/oxfordjournals.qjmed.a066971 · Cited by 498
Drossman, D. A. (1994) · Medical Entomology and Zoology · Cited by 470
Psychiatric Consultation in Somatization Disorder
Smith, G. R., Monson, R. A., & Ray, D. C. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605293142203 · Cited by 459
The functional gastrointestinal disorders
Olden, K. W. (1997) · General Hospital Psychiatry · doi:10.1016/s0163-8343(96)00109-0 · Cited by 437
Somatization and psychiatric disorder in the NIMH Epidemiologic Catchment Area study
Simon, G. E., & VonKorff, M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.11.1494 · Cited by 411
Screening for somatization and hypochondriasis in primary care and neurological in-patients
Fink, P., Ewald, H., Jensen, J., Sørensen, L., Engberg, M., Holm, M., & Munk-Jørgensen, P. (1999) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(98)00092-0 · Cited by 314
Hysteria — The Stability and Usefulness of Clinical Criteria
Perley, M. J., & Guzé, S. B. (1962) · New England Journal of Medicine · doi:10.1056/nejm196203012660901 · Cited by 291
Psychological significance of the irritable colon syndrome
Hislop, I. G. (1971) · Gut · doi:10.1136/gut.12.6.452 · Cited by 246
Shafran, S. D. (1991) · The American Journal of Medicine · doi:10.1016/s0002-9343(05)80063-4 · Cited by 239
Psychiatric illness and irritable bowel syndrome: a comparison with inflammatory bowel disease
Walker, E. A., Roy‐Byrne, P., Katon, W. J., Li, L., Amos, D., & Jiranek, G. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.12.1656 · Cited by 233
Spiller, R. E. (2000) · Gut · doi:10.1136/gut.46.5.741b · Cited by 197
Walker, E. A., Gelfand, A. N., Gelfand, M. D., & Katon, W. J. (1995) · Psychological Medicine · doi:10.1017/s0033291700033225 · Cited by 181
Lumsden, K., Chaudhary, N. A., & Truelove, S. C. (1963) · Clinical Radiology · doi:10.1016/s0009-9260(63)80010-0 · Cited by 163
Abbona, C., GATO, E., & Raffetto, A. (2014) · Springer eBooks · doi:10.1007/978-94-007-0753-5_102136 · Cited by 144
The Medical Basis of Psychiatry
Fatemi, S. H., & Clayton, P. J. (2016) · Springer eBooks · doi:10.1007/978-1-4939-2528-5 · Cited by 128
More accurate diagnosis of irritable bowel syndrome by the use of 'non-colonic' symptomatology.
Maxton, D. G., Morris, J., & Whorwell, P. J. (1991) · Gut · doi:10.1136/gut.32.7.784 · Cited by 121
Somatization and conversion disorders: comorbidity and demographics at presentation
Tómasson, K., Kent, D., & Coryell, W. H. (1991) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1991.tb03146.x · Cited by 116
Somatisation disorder in primary care
Escobar, J. I., Gara, M. A., Silver, R. C., Waitzkin, H. B., Holman, A., & Compton, W. M. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.173.3.262 · Cited by 110
Functional Gastrointestinal Disorders
Whorwell, P. J. (1995) · Gut · doi:10.1136/gut.36.2.320 · Cited by 101
Ranking of symptoms by patients with the irritable bowel syndrome.
Maxton, D. G., Morris, J. A., & Whorwell, P. J. (1989) · BMJ · doi:10.1136/bmj.299.6708.1138 · Cited by 101
Non-Organic Gastrointestinal Illness: A Medical and Psychiatric Study
Macdonald, A. J., & Bouchier, I. A. D. (1980) · The British Journal of Psychiatry · doi:10.1192/bjp.136.3.276 · Cited by 100
The Association of Irritable Bowel Syndrome and Somatization Disorder
Miller, A. R., North, C. S., Clouse, R. E., Wetzel, R. D., Spitznagel, E. L., & Alpers, D. (2001) · Annals of Clinical Psychiatry · doi:10.1023/a:1009060731057 · Cited by 97
Self-citationA randomized, double-blind crossover trial of sertraline in women with chronic pelvic pain
Engel, C. C., Walker, E. A., Engel, A. L., Bullis, J., & Armstrong, A. Y. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00215-8 · Cited by 95
Gynaecological consultation in patients with the irritable bowel syndrome.
Prior, A., & Whorwell, P. J. (1989) · Gut · doi:10.1136/gut.30.7.996 · Cited by 89
Psychologic Considerations in the Irritable Bowel Syndrome
Whitehead, W. E., & Crowell, M. D. (1991) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(21)00549-5 · Cited by 88
Guthrie, E., Creed, F. H., & Whorwell, P. J. (1987) · BMJ · doi:10.1136/bmj.295.6598.577 · Cited by 86
Somatization disorder in a family practice.
deGruy, F. V., Columbia, L., & Dickinson, W. P. (1987) · PubMed · Cited by 73
Somatization Disorder in Primary Care
Monson, R. A., & Smith, G. R. (1983) · New England Journal of Medicine · doi:10.1056/nejm198306163082407 · Cited by 72
Comorbid Irritable Bowel Syndrome in Patients with Generalized Anxiety and Major Depression
Tollefson, G. D., Tollefson, S. L., Pederson, M. W., Luxenberg, M. G., & Dunsmore, G. (1991) · Annals of Clinical Psychiatry · doi:10.3109/10401239109147994 · Cited by 60
The Clinical Management of Hysteria
Murphy, G. E. (1982) · JAMA · doi:10.1001/jama.1982.03320430063034 · Cited by 59
The Medical Basis of Psychiatry
Jefferson, J. W. (1994) · JAMA · doi:10.1001/jama.1994.03520240082049 · Cited by 57
Somatization disorder: Psychologic symptoms, social disability, and diagnosis
Zoccolillo, M., & Cloninger, C. R. (1986) · Comprehensive Psychiatry · doi:10.1016/0010-440x(86)90071-4 · Cited by 49
Somatization in Family Practice
Lynch, D. J., McGrady, A. V., Nagel, R. W., & Zsembik, C. (1999) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.v01n0305 · Cited by 32
Dewsnap, P., Gomborone, J., Libby, G., & Farthing, M. J. G. (1996) · Psychosomatics · doi:10.1016/s0033-3182(96)71553-0 · Cited by 27
Psychiatric Symptoms Endorsed by Somatization Disorder Patients in a Psychiatric Clinic
Lenze, E. J., Miller, A. R., Munir, Z. B., Pornnoppadol, C., & North, C. S. (1999) · Annals of Clinical Psychiatry · doi:10.1023/a:1022342431514 · Cited by 23
Self-citationWetzel, R. D., Guzé, S. B., Cloninger, C. R., Martin, R. L., & Clayton, P. J. (1994) · Psychosomatic Medicine · doi:10.1097/00006842-199411000-00013 · Cited by 21
Washington University: Adult Psychiatry
Guzé, S. B. (1997) · Cited by 16
Problems in the Diagnosis of Somatization Disorder: Effects on Research and Clinical Practice
Martin, R. L. (1988) · Psychiatric Annals · doi:10.3928/0048-5713-19880601-09 · Cited by 10
(2020) · Palgrave Macmillan UK eBooks · doi:10.1057/978-1-349-95988-4_1014 · Cited by 8
Briquet's Syndrome, Somatization Disorder, and Co-Occurring Psychiatric Disorders
Liskow, B. I. (1988) · Psychiatric Annals · doi:10.3928/0048-5713-19880601-07 · Cited by 7
Somatization Disorder in a Southern Community
Swartz, M. S., Blazer, D. G., George, L. K., & Landerman, R. (1988) · Psychiatric Annals · doi:10.3928/0048-5713-19880601-05 · Cited by 4
Comorbidity and psychological distress in irritable bowel syndrome (IBS)
Palsson, O. S., Levy, R. L., Korff, M. V., Feld, A. D., Turner, M. J., & Whitehead, W. E. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)81963-7 · Cited by 3
Research works printed but not linked: 1
- Miller, 2001, Irritable bowel syndrome, psychiatric illness, personality, and abuse, Ann Clin Psychiatry, 13, 25, 10.3109/10401230109147126 · DOI · Paper page
Cited by
Sorted by citations
Guidelines on the irritable bowel syndrome: mechanisms and practical management
Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton, L., Hungin, P., Jones, R., Kumar, D., Rubin, G., Trudgill, N., et al. (2007) · Gut · doi:10.1136/gut.2007.119446 · Cited by 818
Psychosocial Aspects of the Functional Gastrointestinal Disorders
Levy, R. L., Olden, K. W., Naliboff, B. D., Bradley, L. A., Francisconi, C., Drossman, D. A., & Creed, F. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.057 · Cited by 776
Altered Rectal Perception in Irritable Bowel Syndrome Is Associated With Symptom Severity
Posserud, I., Syrous, A., Lindström, L., Tack, J., Abrahamsson, H., & Simrén, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.07.024 · Cited by 248
Layer, P., Andresen, V., Pehl, C., Allescher, H. ‐., Bischoff, S., Claßen, M., Enck, P., Frieling, T., Haag, S., Holtmann, G., et al. (2011) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0029-1245976 · Cited by 236
Spiller, R. E., Humes, D. J., Campbell, E., Hastings, M. C., Neal, K. R., Dukes, G. E., & Whorwell, P. J. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04402.x · Cited by 241
Metadata
- Authors
- North, C. S., Downs, D., Clouse, R. E., Alrakawi, A., Dokucu, M. E., Cox, J., Spitznagel, E. L., & Alpers, D. H.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- North, Carol S.
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 2
- Issue
- 9
- Pages
- 787-795
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2172216861
- Cited by
- 102
- References
- 51
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 5 · 2014: 7 · 2013: 8 · 2012: 8
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- irritable bowel syndrome, somatization disorder, psychiatric comorbidity, functional gastrointestinal disorders, health care utilization, medically unexplained symptoms, benzodiazepine use, lost workdays, treatment dissatisfaction, women
- MeSH terms
- Adolescent, Adult, Aged, Female, Health Services, Humans, Middle Aged, Surveys and Questionnaires, Somatoform Disorders, Comorbidity, Prevalence, Irritable Bowel Syndrome
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