Do antinuclear antibodies in primary biliary cirrhosis patients identify increased risk for liver failure?
Open accessAbstract
Background & aims Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease with a variable clinical course. Identification of serologic markers associated with increased risk of liver failure would assist in management of PBC patients. The objective of this study was to identify antinuclear antibody (ANA) markers that may be used to predict PBC outcome. Methods Indirect immunofluorescence was used to identify ANAs in 492 PBC patients. chi2 and Kaplan-Meier analyses were used to examine the association between ANAs and liver failure. Results A greater percentage of ANA-positive, compared to ANA-negative, PBC patients developed liver failure (41% vs 25%, P = .005). The presence of anti-centromere antibodies was associated with liver failure (anti-centromere antibody positive vs negative, 58% vs 33%, P = .001). The time to liver failure was shorter in ANA-positive, compared with ANA-negative, patients (log rank score 5.8, P = .02). After 8.9 years (the median follow-up for patients without liver failure), 68% of ANA-positive and 81% of ANA-negative patients were free of liver failure. Anti-centromere antibodies were also associated with a shorter time to liver failure (log rank score 8.4, P = .004). After 8.9 years, 52% of anti-centromere antibody positive and 74% of anti-centromere antibody negative patients were without liver failure. Conclusions ANAs in general, and anti-centromere antibodies in particular, are associated with liver failure in PBC. PBC patients with ANAs may be candidates for treatment with experimental therapies to prolong the interval between diagnosis and liver failure. ANA-negative patients, who appear to have a relatively benign clinical course, should perhaps be treated with ursodeoxycholic acid alone.
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There is evidence to suggest that PBC-linked ANA (in particular anti-gp210/anti-nuclear rim antibody) may be associated with more rapidly progressive disease and disease which is less responsive to UDCA therapy.
“There is evidence to suggest that PBC-linked ANA (in particular anti-gp210/anti-nuclear rim antibody) may be associated with more rapidly progressive disease and disease which is less responsive to UDCA therapy.76 79–82”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [80]
Cites
Kaplan, M. M. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702263160907 · Cited by 2,015 · see citing works
Range of antinuclear antibodies in “healthy” individuals
Tan, E. M., Feltkamp, T. E. W., Smolen, J. S., Butcher, B. T., Dawkins, R. L., Fritzler, M. J., Gordon, T. P., Hardin, J., Kalden, J. R., Lahita, R. G., et al. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400909 · Cited by 879 · see citing works
Prognosis in primary biliary cirrhosis: Model for decision making
Dickson, R. E., Grambsch, P. M., Fleming, T. R., Fisher, L. D., & Langworthy, A. (1989) · Hepatology · doi:10.1002/hep.1840100102 · Cited by 816 · see citing works
Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis)
Ludwig, J., Dickson, E. R., & McDonald, G. S. A. (1978) · Virchows Archiv A Pathological Anatomy and Histology · doi:10.1007/bf00432479 · Cited by 753 · see citing works
Carey, E. J., Ali, A. H., & Lindor, K. D. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00154-3 · Cited by 735 · see citing works
Self-citationUrsodeoxycholic acid in the treatment of primary biliary cirrhosis
Lindor, K. D., Dickson, E. R., Baldus, W. P., Jorgensen, R. A., Ludwig, J., Murtaugh, P. A., Harrison, J. M., Wiesner, R. H., Anderson, M. L., Lange, S. M., et al. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90021-3 · Cited by 487 · see citing works
Self-citationKaplan, M. M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199611213352107 · Cited by 455 · see citing works
Invernizzi, P., Podda, M., Battezzati, P. M., Crosignani, A., Zuin, M. G., Hitchman, E., Maggioni, M., Meroni, P. L., Penner, E., & Węsierska‐Gądek, J. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(00)00040-4 · Cited by 454 · see citing works
Züchner, D., Sternsdorf, T., Szostecki, C., Heathcote, E. J., Cauch-Dudek, K., & Will, H. (1997) · Hepatology · doi:10.1053/jhep.1997.v26.pm0009362351 · Cited by 405 · see citing works
Prince, M., Chetwynd, A., Newman, W., Metcalf, J. V., & James, O. F. W. (2002) · Gastroenterology · doi:10.1053/gast.2002.36027 · Cited by 348 · see citing works
Corpechot, C., Carrat, F., Bonnand, A.-M., Poupon, R. E., & Poupon, R. (2000) · Hepatology · doi:10.1053/jhep.2000.20240 · Cited by 316 · see citing works
Talwalkar, J. A., & Lindor, K. D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13808-1 · Cited by 299 · see citing works
Self-citationPrimary biliary cirrhosis with scleroderma, Raynaud's phenomenon and telangiectasia
Reynolds, T. B., Denison, E. K., Frankl, H. D., Lieberman, F. L., & Peters, R. L. (1971) · The American Journal of Medicine · doi:10.1016/0002-9343(71)90218-x · Cited by 225 · see citing works
Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis
Muratori, P., Muratori, L., Ferrari, R., Cassani, F., Bianchi, G., Lenzi, M., Rodrigo, L., Linares, A., Fuentes, D., & Bianchi, F. B. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07257.x · Cited by 204 · see citing works
Joshi, S., Cauch-Dudek, K., Wanless, I. R., Lindor, K. D., Jorgensen, R., Batts, K., & Heathcote, J. E. (2002) · Hepatology · doi:10.1053/jhep.2002.30902 · Cited by 174 · see citing works
Self-citationMahl, T. C., Shockcor, W., & Boyer, J. L. (1994) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80139-4 · Cited by 163 · see citing works
Asymptomatic primary biliary cirrhosis
Beswick, D. R., Klatskin, G., & Boyer, J. L. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90325-7 · Cited by 148 · see citing works
Scleroderma and Primary Biliary Cirrhosis
Murray-Lyon, I. M., Thompson, R. P. H., Ansell, I. D., & Williams, R. L. (1970) · BMJ · doi:10.1136/bmj.3.5717.258 · Cited by 143 · see citing works
Asymptomatic primary biliary cirrhosis: a study of its natural history and prognosis
Springer, J., Cauch-Dudek, K., O'Rourke, K., Wanless, I. R., & Heathcote, E. J. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.00770.x · Cited by 141 · see citing works
Antimitochondrial Antibodies in Primary Biliary Cirrhosis
Leung, P. S. C., Coppel, R. L., Ansari, A. A., Muñoz, S. J., & Gershwin, M. E. (1997) · Seminars in Liver Disease · doi:10.1055/s-2007-1007183 · Cited by 139 · see citing works
Talwalkar, J. A., Keach, J. C., Angulo, P., & Lindor, K. D. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05703.x · Cited by 127 · see citing works
Self-citationRheumatic disorders and primary biliary cirrhosis: an appraisal of 170 Italian patients
Marasini, B., Gagetta, M., Rossi, A., & Ferrari, P. A. (2001) · Annals of the Rheumatic Diseases · doi:10.1136/ard.60.11.1046 · Cited by 123 · see citing works
ITOH, S., Ichida, T., Yoshida, T., Hayakawa, A., UCHIDA, M., Tashiro‐Itoh, T., Matsuda, Y., Ishihara, K., & Asakura, H. (1998) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.1998.01553.x · Cited by 117 · see citing works
Joshi, S., Cauch-Dudek, K., Heathcote, E., Lindor, K., Jorgensen, R., & Klein, R. (2002) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05620.x · Cited by 61 · see citing works
Self-citationPrevalence of IgA Antibodies to Endomysium and Tissue Transglutaminase in Primary Biliary Cirrhosis
Gillett, H. R., Cauch‐Dudek, K., Healthcote, E. J. L., & Freeman, H. J. (2000) · Canadian Journal of Gastroenterology · doi:10.1155/2000/934709 · Cited by 55 · see citing works
Kim, W., Wiesner, R., Poterucha, J. J., Therneau, T., Benson, J., Krom, R., & Dickson, E. R. (2000) · Liver transplantation · doi:10.1053/jlts.2000.6503 · Cited by 54 · see citing works
Positive markers in AMA-negative PBC
Vergani, D., & Bogdanos, D. P. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07270.x · Cited by 53 · see citing works
Results of long-term ursodiol treatment for patients with primary biliary cirrhosis
Jorgensen, R. A., Angulo, P., Dickson, E. R., & Lindor, K. D. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.06043.x · Cited by 45 · see citing works
Self-citationAnti-Centromere Antibody and CREST Syndrome in Patients with Primary Biliary Cirrhosis.
Shoji, I., TAKAGI, T., & Kasukawa, R. (1992) · Internal Medicine · doi:10.2169/internalmedicine.31.1348 · Cited by 34 · see citing works
Beswick, D. R., & Boyer, J. L. (1984) · Hepatology · doi:10.1002/hep.1840040710 · Cited by 22 · see citing works
Remmel, T., Piirsoo, A., Kǒiveer, A., Remmel, H., Uibo, R., & Salupere, V. (1996) · PubMed · Cited by 22 · see citing works
Heathcote, J. E., Cauch-Dudek, K., Walker, V., Bailey, R. J., Blendis, L. M., Ghent, C. N., Michieletti, P., Minuk, G. Y., Pappas, C. S., Scully, L. J., et al. (1994) · Hepatology · doi:10.1002/hep.1840190512 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Nakamura, M., Kondo, H., Mori, T., Komori, A., Matsuyama, M., Ito, M., Takii, Y., Koyabu, M., Yokoyama, T., Migita, K., et al. (2007) · Hepatology · doi:10.1002/hep.21472 · Cited by 365 · see citing works
Hirschfield, G. M., Dyson, J. K., Alexander, G. J. M., Chapman, M. H., Collier, J., Hübscher, S., Patanwala, I., Pereira, S. P., Thain, C., Thorburn, D., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315259 · Cited by 347 · see citing works
Autoimmune liver serology: Current diagnostic and clinical challenges
Bogdanos, D. P., Invernizzi, P., Mackay, I. R., & Vergani, D. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3374 · Cited by 211 · see citing works
Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body
YU, J. H., Yang, W.-H., Gulick, T., Bloch, K. D., & Bloch, D. B. (2005) · RNA · doi:10.1261/rna.2142405 · Cited by 199 · see citing works
Self-citationCorrelation of initial autoantibody profile and clinical outcome in primary biliary cirrhosis
Wesierska-Gadek, J., Penner, E., Battezzati, P. M., Selmi, C., Zuin, M., Hitchman, E., Worman, H. J., Gershwin, E. M., Podda, M., & Invernizzi, P. (2006) · Hepatology · doi:10.1002/hep.21172 · Cited by 177 · see citing works
RNA-associated protein 55 (RAP55) localizes to mRNA processing bodies and stress granules
Yang, W.-H., YU, J. H., Gulick, T., Bloch, K. D., & Bloch, D. B. (2006) · RNA · doi:10.1261/rna.2302706 · Cited by 172 · see citing works
Self-citationNew Treatment Paradigms in Primary Biliary Cholangitis
Levy, C., Manns, M. P., & Hirschfield, G. M. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.02.005 · Cited by 141 · see citing works
The challenges of primary biliary cholangitis: What is new and what needs to be done
Terziroli Beretta-Piccoli, B., Mieli-Vergani, G., Vergani, D., Vierling, J. M., Adams, D., Alpini, G., Banales, J. M., Beuers, U., Björnsson, E., Bowlus, C., et al. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102328 · Cited by 114 · see citing works
Guidelines for the management of primary biliary cirrhosis
Cirrhosis, W. S. (. V. F. C. P. G. F. P. B. (2014) · Hepatology Research · doi:10.1111/hepr.12270 · Cited by 111 · see citing works
Infectome: A platform to trace infectious triggers of autoimmunity
Bogdanos, D. P., Smyk, D. S., Invernizzi, P., Rigopoulou, E. I., Blank, M., Pouria, S., & Shoenfeld, Y. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.12.005 · Cited by 109 · see citing works
Interpreting serological tests in diagnosing autoimmune liver diseases
Invernizzi, P., Lleo, A., & Podda, M. (2007) · Seminars in Liver Disease · doi:10.1055/s-2007-979469 · Cited by 107 · see citing works
GRANITO, A., MURATORI, P., MURATORI, L., PAPPAS, G., CASSANI, F., WORTHINGTON, J., FERRI, S., QUARNETI, C., CIPRIANO, V., DE MOLO, C., et al. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03433.x · Cited by 102 · see citing works
Identification of New Autoantigens for Primary Biliary Cirrhosis Using Human Proteome Microarrays
Hu, C.-J., Song, G., Huang, W., Liu, G.-Z., Deng, C., Zeng, H.-P., Wang, L., Zhang, F.-C., Zhang, X., Jeong, J. S., et al. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.015529 · Cited by 95 · see citing works
Etiopathogenesis of primary biliary cirrhosis
Lleò, A., Invernizzi, P., Mackay, I. R., Prince, H., Zhong, R., & Gershwin, M. E. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3328 · Cited by 94 · see citing works
Disease-specific autoantibodies in primary biliary cirrhosis
Bogdanos, D. P., & Komorowski, L. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.12.019 · Cited by 93 · see citing works
Antinuclear antibodies as ancillary markers in primary biliary cirrhosis
Granito, A., Muratori, P., Quarneti, C., Παππάς, Γ., Cicola, R., & Muratori, L. (2011) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.11.82 · Cited by 86 · see citing works
Probing the mRNA processing body using protein macroarrays and "autoantigenomics"
Yang, W., & Bloch, D. B. (2007) · RNA · doi:10.1261/rna.411907 · Cited by 86 · see citing works
Self-citationPML Nuclear Body Component Sp140 Is a Novel Autoantigen in Primary Biliary Cirrhosis
Granito, A., Yang, W.-H., Muratori, L., Lim, M. J., Nakajima, A., Ferri, S., Παππάς, Γ., Quarneti, C., Bianchi, F. B., Bloch, D. B., et al. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.596 · Cited by 82 · see citing works
Self-citationAutoantibodies as Prognostic Markers in Autoimmune Liver Disease
Czaja, A. J. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1268-4 · Cited by 77 · see citing works
Mechanisms of tissue injury in autoimmune liver diseases
Liaskou, E., Hirschfield, G. M., & Gershwin, M. E. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0439-3 · Cited by 73 · see citing works
Update on primary biliary cirrhosis
Invernizzi, P., Selmi, C. F., & Gershwin, M. E. (2010) · Digestive and Liver Disease · doi:10.1016/j.dld.2010.02.014 · Cited by 70 · see citing works
Clinical Significance of Autoantibodies in Primary Biliary Cirrhosis
Nakamura, M. (2014) · Seminars in Liver Disease · doi:10.1055/s-0034-1383732 · Cited by 69 · see citing works
Diagnostic and clinical significance of anti-centromere antibodies in primary biliary cirrhosis
Liberal, R., Grant, C. R., Sakkas, L. I., Bizzaro, N., & Bogdanos, D. P. (2013) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2013.04.005 · Cited by 65 · see citing works
Gatselis, N., Zachou, K., Norman, G., Gabeta, S., Papamichalis, P., Koukoulis, G., & Dalekos, G. (2013) · Autoimmunity · doi:10.3109/08916934.2013.801461 · Cited by 67 · see citing works
Clinical Epidemiology of Primary Biliary Cirrhosis
Lazaridis, K. N., & Talwalkar, J. A. (2007) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000225653.07932.8f · Cited by 63 · see citing works
B-cell involvement in chronic graft-versus-host disease
Kapur, R., Ebeling, S. B., & Hagenbeek, A. (2008) · Haematologica · doi:10.3324/haematol.13311 · Cited by 56 · see citing works
Epstein-Barr Virus as a Trigger of Autoimmune Liver Diseases
Rigopoulou, E. I., Smyk, D. S., Matthews, C. E., Billinis, C., Burroughs, A. K., Lenzi, M., & Bogdanos, D. P. (2012) · Advances in Virology · doi:10.1155/2012/987471 · Cited by 55 · see citing works
Value of Autoantibody Analysis in the Differential Diagnosis of Chronic Cholestatic Liver Disease
Milkiewicz, P., Buwaneswaran, H., Coltescu, C., Shums, Z., Norman, G. L., & Heathcote, E. J. (2009) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2009.07.012 · Cited by 47 · see citing works
Autoantibodies to GW bodies and other autoantigens in primary biliary cirrhosis
Stinton, L. M., Swain, M., Myers, R. P., Shaheen, A., & Fritzler, M. (2011) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2010.04288.x · Cited by 49 · see citing works
Natural History of Primary Biliary Cirrhosis
Mayo, M. J. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2008.02.012 · Cited by 45 · see citing works
The value of antinuclear antibodies in primary biliary cirrhosis
Gao, L., Tian, X., Liu, B., & Zhang, F. (2008) · Clinical and Experimental Medicine · doi:10.1007/s10238-008-0150-6 · Cited by 44 · see citing works
Primary Biliary Cirrhosis: Family Stories
Smyk, D. S., Cholongitas, Ε., Kriese, S., Rigopoulou, E. I., & Bogdanos, D. P. (2011) · Autoimmune Diseases · doi:10.4061/2011/189585 · Cited by 38 · see citing works
The Significance of Autoantibody Changes Over Time in Primary Biliary Cirrhosis
Tana, M. M.-S., Shums, Z., Milo, J. L., Norman, G. L., Leung, P. S. C., Gershwin, M. E., Noureddin, M., Kleiner, D. E., Zhao, X., Heller, T., et al. (2015) · American Journal of Clinical Pathology · doi:10.1309/ajcpqv4a7qaeefev · Cited by 38 · see citing works
Tracing environmental markers of autoimmunity: introducing the infectome
Bogdanos, D. P., Smyk, D. S., Invernizzi, P., Rigopoulou, E. I., Blank, M., Sakkas, L. I., Pouria, S., & Shoenfeld, Y. (2013) · Immunologic Research · doi:10.1007/s12026-013-8399-6 · Cited by 37 · see citing works
Risk Factors and Prediction of Long-term Outcome in Primary Biliary Cirrhosis
Ishibashi, H., Komori, A., Shimoda, S., Ambrosini, Y. M., Gershwin, M. E., & Nakamura, M. (2011) · Internal Medicine · doi:10.2169/internalmedicine.50.4462 · Cited by 36 · see citing works
Villalta, D., Sorrentino, M. C., Girolami, E., Tampoia, M., Alessio, M. G., Brusca, I., Daves, M., Porcelli, B., Barberio, G., & Bizzaro, N. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.08.024 · Cited by 35 · see citing works
Nakamura, M., Komori, A., Ito, M., Kondo, H., Aiba, Y., Migita, K., Nagaoka, S., Ohata, K., Yano, K., Abiru, S., et al. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00244.x · Cited by 34 · see citing works
Role of autoantibodies in the clinical management of primary biliary cholangitis
Rigopoulou, E. I., & Bogdanos, D. P. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i12.1795 · Cited by 30 · see citing works
Current Concepts in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis
Sclair, S. N., Little, E. C., & Levy, C. (2015) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2015.33 · Cited by 33 · see citing works
Primary biliary cirrhosis in adults
Momah, N., & Lindor, K. D. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.888950 · Cited by 33 · see citing works
Self-citationVílchez-Oya, F., Balastegui-Martín, H., García-Martínez, E., & Corominas, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1003054 · Cited by 31 · see citing works
Molecular diagnostics of primary biliary cirrhosis
Rigopoulou, E. I., & Dalekos, G. N. (2008) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2.6.621 · Cited by 28 · see citing works
Risk factors for hepatic decompensation in patients with primary biliary cirrhosis.
Shi, T.-Y., Zhang, L.-N., Chen, H., Wang, L., Shen, M., Zhang, X., & Zhang, F.-C. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i7.1111 · Cited by 29 · see citing works
Characterization of Autoantibodies against Components of the Nuclear Pore Complexes
Węsierska‐Gądek, J., KLIMA, A., Komina, O., Ranftler, C., Invernizzi, P., & Penner, E. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1398.058 · Cited by 26 · see citing works
Natural history of primary biliary cirrhosis
Abe, M., & Onji, M. (2008) · Hepatology Research · doi:10.1111/j.1872-034x.2008.00351.x · Cited by 25 · see citing works
Peri-nuclear antibodies correlate with survival in Greek primary biliary cirrhosis patients
Sfakianaki, O. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i39.4938 · Cited by 21 · see citing works
Bloch, D. B., Li, P., Bloch, E. G., Berenson, D. F., Galdos, R. L., Arora, P. K., Malhotra, R. K., Wu, C., & Yang, W.-H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094784 · Cited by 18 · see citing works
Self-citationBauer, A., Habior, A., & Gaweł, D. (2022) · Biomedicines · doi:10.3390/biomedicines10040801 · Cited by 15 · see citing works
Trevisani, V. F., Pinheiro, A., Fialho, S. C. D. M. S., Fernandes, M., Pugliesi, A., Pasoto, S., Lopes, M. L., Guedes, L., Miyamoto, S., dos Santos, L. C., et al. (2022) · Advances in Rheumatology · doi:10.1186/s42358-022-00267-y · Cited by 10 · see citing works
Park, Y., Lee, J. J., Koh, J. H., Choe, J., Sung, Y., Lee, S., Kim, J., Park, S., & Kwok, S. (2020) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2020.146 · Cited by 15 · see citing works
Current concepts in the pathogenesis of primary biliary cirrhosis
Charatcharoenwitthaya, P., & Lindor, K. D. (2005) · Annals of Hepatology · doi:10.1016/s1665-2681(19)32061-7 · Cited by 15 · see citing works
Self-citationGW/P-Bodies and Autoimmune Disease
Bloch, D. B., Nobre, R. A., & Yang, W.-H. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5107-5_5 · Cited by 14 · see citing works
Self-citationDing, D., Jia, G., Cui, L., Liu, Y., Wang, X., Sun, R., Deng, J., Guo, G., Shang, Y., & Han, Y. (2025) · Digestive and Liver Disease · doi:10.1016/j.dld.2024.12.024 · Cited by 13 · see citing works
Himoto, T., Nakai, S., Kinekawa, F., Yoneyama, H., Deguchi, A., Kurokochi, K., Masaki, T., Senda, S., Haba, R., Watanabe, S., et al. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0359-y · Cited by 13 · see citing works
Himoto, T., Murota, M., Yoneyama, H., Deguchi, A., Kurokochi, K., Senda, S., Haba, R., Watanabe, S., Nishioka, M., & Masaki, T. (2010) · Hepatology Research · doi:10.1111/j.1872-034x.2010.00684.x · Cited by 12 · see citing works
Serum autoantibodies for the diagnosis and management of autoimmune liver diseases
Achenza, M. I. S., Meda, F., Brunetta, E., & Selmi, C. F. (2012) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.12.58 · Cited by 11 · see citing works
Autoantibodies to speckled protein family in primary biliary cholangitis
Granito, A., Muratori, L., Tovoli, F., & Muratori, P. (2021) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-021-00539-0 · Cited by 11 · see citing works
Chen, Q., Zhong, R., Dong, K., Wang, Y., Kui, Y., Ma., B.-S., Wen, X., & Jin, Q. (2021) · Digestive and Liver Disease · doi:10.1016/j.dld.2021.10.011 · Cited by 11 · see citing works
Predicting and preventing autoimmunity: the case of anti-mitochondrial antibodies
Milkiewicz, M., Caballería, L., Smyk, D. S., & Milkiewicz, P. (2012) · Autoimmunity Highlights · doi:10.1007/s13317-012-0038-z · Cited by 11 · see citing works
Bauer, A., Habior, A., & Kraszewska, E. (2012) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2012.741088 · Cited by 10 · see citing works
Autorinnen/Autoren, & Collaborators (2025) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2558-5204 · Cited by 6 · see citing works
Ishibashi, H., Nakanuma, Y., Ueno, Y., Egawa, H., Koike, K., Komori, A., Sakisaka, S., Shimoda, S., Shirabe, K., Zeniya, M., et al. (2012) · Kanzo · doi:10.2957/kanzo.53.633 · Cited by 6 · see citing works
Marí-Alfonso, B., Amengual, M. J., Vergara, M., Simeón‐Aznar, C. P., Fonollosa‐Pla, V., Jove-Buxeda, E., Oliva-Morera, J., & Tolosa-Vilella, C. (2015) · Medicina Clínica · doi:10.1016/j.medcli.2015.02.026 · Cited by 5 · see citing works
Invernizzi, P., Leung, P. S. C., Ma, X., & Gershwin, M. E. (2013) · Springer eBooks · doi:10.1007/978-3-319-02096-9_18 · Cited by 5 · see citing works
Popular and unpopular infectious agents linked to primary biliary cirrhosis
Koutsoumpas, A. L., Kriese, S., & Rigopoulou, E. I. (2012) · Autoimmunity Highlights · doi:10.1007/s13317-012-0039-y · Cited by 4 · see citing works
Autoantibodies in the diagnostics, prognostics and follow-up of primary biliary cholangitis
Antal‐Szalmás, P., Bencze, D., Demeter, S., Pénzes, K., Szabó, L., Tóth, B., Földesi, R., Papp, M., & Nagy, G. (2026) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2026.100366 · Cited by 2 · see citing works
Sebode, M., Bantel, H., Baumann, U., Bufler, P., Demir, M., Dold, L., Keitel, V., Klein, R., Kremer, A. E., Jansen, P. L., et al. (2026) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2769-2475 · Cited by 2 · see citing works
Marí-Alfonso, B., Amengual, M. J., Vergara, M., Simeón‐Aznar, C. P., Fonollosa‐Pla, V., Jove-Buxeda, E., Oliva-Morera, J., & Tolosa-Vilella, C. (2016) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2016.04.035 · Cited by 2 · see citing works
Zhao, D., Liu, Y., Han, Y., Zhang, H., Zhao, Y., & Yan, H. (2020) · Medicine · doi:10.1097/md.0000000000018856 · Cited by 2 · see citing works
Koenig, M., Joyal, F., Vincent, C., Fritzler, M. J., Poliquin, M., Dominguez, M., & Senécal, J. (2008) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2008.10.219 · Cited by 1 · see citing works
Primary Biliary Cholangitis: Its Science and Practice
Wang, L., Bowlus, C. L., Wang, F., & Gershwin, M. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-50168-0_8 · Cited by 1 · see citing works
Dancygier, H. (2009) · Springer eBooks · doi:10.1007/978-3-642-04519-6_19
Auto-anticuerpos en las enfermedades hepáticas
Aj, M. L., & Angulo, P. (2007) · Revista Portuguesa de Pneumologia
Correlation of Anti-mitochondrial Antibodies with Liver Histology and Outcomes
Tan, S. Y., Movahedi, Z., Beisel, J. C., Ayutyanont, N., & Nadir, A. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4094-5
Anti-centromere Antibody-positive Primary Biliary Cirrhosis with Rapid Development
Suzuki, Y., Abe, M., Hosoki, Y., Miyoshi, S., Inoue, M., Ohhira, M., Ohtake, T., & Kohgo, Y. (2008) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.97.144
Chaltsev, B. D., Vasiliev, V., Palshina, S. G., Torgashina, A. V., Владимировна, С. Е., Khvan, Y. I., Rodionova, E. B., Safonova, T. N., & Некрасова, Т. П. (2021) · Modern Rheumatology Journal · doi:10.14412/1996-7012-2021-3-27-34
Autoantibodies in Primary Biliary Cirrhosis
Komori, A. (2014) · Springer eBooks · doi:10.1007/978-4-431-54789-1_17
Anti-Centromere Antibody-positive Primary Biliary Cirrhosis with Rapid Development
泰猛, 山., & 康秋, 鈴. (2008) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.97.1105
Qasim, B., Kumari, H., Kashif, S. N., Abbas, S. M. I., Hani, O., Salma, O., Sauleh, A., Adnan, F., Ali, M., Raheem, A., et al. (2025) · Egyptian Liver Journal · doi:10.1186/s43066-025-00464-6
Martinroche, G. (2024) · theses.fr (ABES) · doi:10.70675/7aeee875z2286z46d5z98e4z51e699b8b387
Ando, Y., Mabuchi, S., Nakayama, S., Honda, A., Hokari, R., Harada, K., & Murashima, N. (2026) · Pathology International · doi:10.1111/pin.70179
- Authors
- Yang, W.-H., Yu, J. H., Nakajima, A., Neuberg, D., Lindor, K., & Bloch, D. B.
- Affiliations
- Harvard University (US)
- Mayo Clinic (US)
- Corresponding author
- Bloch, Donald B.
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2004-12
- Volume
- 2
- Issue
- 12
- Pages
- 1116-1122
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2015610424
- Cited by
- 83
- References
- 32
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 10
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 40561, R29DK051179, DK051179, P30DK040561)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- primary biliary cirrhosis, antinuclear antibodies, anti-centromere antibodies, liver failure, serological markers, prognosis, cholestatic liver disease, ursodeoxycholic acid
- MeSH terms
- Antibodies, Antinuclear, Centromere, Female, Follow-Up Studies, Humans, Liver Cirrhosis, Biliary, Male, Middle Aged, Cohort Studies, Biomarkers, Liver Failure, Risk Assessment, Fluorescent Antibody Technique, Indirect
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