Autoantibody-induced apoptosis as a possible mechanism of autoimmune retinopathy
Abstract
Circulating antibodies specific to retinal proteins have been associated with retinal dysfunction in patients with retinopathy. Anti-recoverin antibodies found in patients with cancer-associated retinopathy (CAR) represent a unique model to study the relationship between retinal degeneration and autoimmunity. A body of evidence from in vitro and in vivo studies indicates that anti-recoverin autoantibodies are cytotoxic to retinal cells and induce apoptotic death of retinal photoreceptor cells, which leads to the degeneration of the photoreceptor cell layer. Similar to anti-recoverin autoantibodies, antibodies with other retinal specificities induce their target retinal cell death by activating a caspase 3-dependent apoptotic pathway. Thus, autoantibody-induced apoptosis may be a common pathway that leads to retinal death and blindness.
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All eye tissues except the lens contain antibodies.
“All eye tissues except for the lens contain antibodies, and antibodies have been shown to be capable of mediating ocular pathology in multiple contexts21–25.”
From Investigation of Cas9 Antibodies in the Human Eye (2022) · cites this paper as [23]
Antibodies have been shown to be capable of mediating ocular pathology in multiple contexts.
“All eye tissues except for the lens contain antibodies, and antibodies have been shown to be capable of mediating ocular pathology in multiple contexts21–25.”
From Investigation of Cas9 Antibodies in the Human Eye (2022) · cites this paper as [23]
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Is Zonal Occult Outer Retinopathy an Autoimmune Disease?
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Self-citationDiagnosis and treatment of autoimmune retinopathy: review of current approaches
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Anti-retinal Antibodies in Sarcoidosis
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Structural and Functional Changes in Non-Paraneoplastic Autoimmune Retinopathy
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Unique and progressive retinal degeneration in a patient with cancer associated retinopathy
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PERSISTENT DIFFUSE PHOTORECEPTOR DISORGANIZATION
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A Case of Nonparaneoplastic Autoimmune Retinopathy
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Correlation of Anti-TULP1 Autoantibodies with Breast Cancer and Autoimmune Retinopathy
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Characteristics of Visual Electrophysiology in Inflammatory Disorders
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Nonparaneoplastic and Paraneoplastic Autoimmune Retinopathies
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Paraneoplastic Visual Syndromes
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Nonparaneoplastic and Paraneoplastic Autoimmune Retinopathies
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Role of Microorganisms in Pathogenesis and Management of Autoimmune Retinopathy (AIR)
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Electrodiagnostic Biomarkers in Paraneoplastic Retinopathy
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- Authors
- Adamus, G.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Adamus, Grazyna
- ORCID
- Adamus, Grazyna
- Venue
- Autoimmunity Reviews
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 2
- Issue
- 2
- Pages
- 63-68
- ISSN
- 1568-9972 (ISSN-L)
- OpenAlex
- W2093860835
- Cited by
- 102
- References
- 39
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2015: 9 · 2014: 1 · 2013: 5 · 2012: 5
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Autoimmunity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- autoimmune retinopathy, autoantibodies, apoptosis, cancer-associated retinopathy, photoreceptor cell death, retinal degeneration, caspase-3, retinal proteins, blindness
- MeSH terms
- Animals, Autoantibodies, Calcium-Binding Proteins, Enzyme Activation, Eye Proteins, Humans, Lipoproteins, Models, Biological, Nerve Tissue Proteins, Paraneoplastic Syndromes, Retinal Degeneration, Retinal Diseases, Apoptosis, Caspases, Photoreceptor Cells, Vertebrate, Hippocalcin, Recoverin
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