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Cited by 41PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingMetabolism, Diabetes, and Cancer

Rheb G-Proteins and the Activation of mTORC1

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Nitika Parmar, Fuyuhiko Tamanoi·2010·The Enzymes
DOI 10.1016/s1874-6047(10)27003-8PMC PMC4241847
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Abstract

Rheb belongs to a unique family within the Ras superfamily of G-proteins. Although initially identified in rat brain, this G-protein is highly conserved from yeast to human. While only one Rheb is present in lower eukaryotes, two Rheb proteins exist in mammalian cells. A number of studies establish that one of the functions of Rheb is to activate mTOR leading to growth. In particular, the ability of Rheb to activate mTORC1 in vitro points to direct interaction of Rheb with the mTORC1 complex. Additional functions of Rheb that are independent of mTOR have also been suggested.

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  • TSC2 constitutively downregulates mTORC1 activity by GTP hydrolysis of Rheb GTPase.

    “TSC2 constitutively downregulates mTORC1 activity by GTP hydrolysis of the Rheb GTPase (28).”

    From Enhanced mTORC1 signaling and Protein Synthesis in Parkinson’s Disease Pathogenesis Disease Pathogenesis (2022) · cites this paper as [28]

    Section II.E states that the TSC1/TSC2 complex stimulates GTP hydrolysis by Rheb, converting it from the GTP-bound to the GDP-bound form. Section V links Rheb to mTORC1 activation. The copy does not establish that TSC2 acts alone or *constitutively* downregulates mTORC1 activity. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Parmar, N., & Tamanoi, F.
Affiliations
  • California State University, Channel Islands (US)
  • University of California, Los Angeles (US)
ORCID
Fuyuhiko Tamanoi
Venue
The Enzymes
Publisher
Elsevier
Published
2010
Volume
27
Pages
39-56
ISSN
1874-6047 (ISSN-L)
DOI
10.1016/s1874-6047(10)27003-8
PMC
PMC4241847
OpenAlex
W390580360
Cited by
41
References
6
Citations by year
2026: 5 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 5 · 2015: 1
FWCI
0.00
Type
book chapter
Language
en
Open access
Licence
Locations
  • The Enzymes (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (R01CA041996)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
Rheb, G proteins, Ras superfamily, mTORC1, mTOR activation, cell growth regulation, conserved protein

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