Rheb Activates mTOR by Antagonizing Its Endogenous Inhibitor, FKBP38

TOR signaling in growth and metabolism

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

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Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

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Rheb Binds and Regulates the mTOR Kinase

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

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The expanding TOR signaling network

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Rheb fills a GAP between TSC and TOR

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TSC2: filling the GAP in the mTOR signaling pathway

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Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency

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Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

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Biochemical and Functional Characterizations of Small GTPase Rheb and TSC2 GAP Activity

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The Rheb family of GTP-binding proteins

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Bcl‐2 regulator FKBP38 is activated by Ca2+/calmodulin

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Regulation of the small GTPase Rheb by amino acids

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The mode of action of peptidyl prolyl cis/trans isomerases in vivo: binding vs. catalysis

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Identification of Dominant Negative Mutants of Rheb GTPase and Their Use to Implicate the Involvement of Human Rheb in the Activation of p70S6K

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The Specific FKBP38 Inhibitor N-(N′,N′-Dimethylcarboxamidomethyl)cycloheximide Has Potent Neuroprotective and Neurotrophic Properties in Brain Ischemia

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) ¹

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The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

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mTOR signaling: At the crossroads of plasticity, memory and disease

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Mitochondrial and metabolic dysfunction in ageing and age-related diseases

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

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The PTEN–PI3K pathway: of feedbacks and cross-talks

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Regulation of mTORC1 by PI3K Signaling

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FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt

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Targeting protein prenylation for cancer therapy

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The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

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Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

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Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

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PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control

Georgescu, M. (2010) · Genes & Cancer · doi:10.1177/1947601911407325 · Cited by 490 · see citing works

Rapamycin and mTOR kinase inhibitors

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FKBP8 recruits LC3A to mediate Parkin‐independent mitophagy

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The tuberous sclerosis complex

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Amino acid regulation of TOR complex 1

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Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

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Direct control of mitochondrial function by mTOR

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The PI3K-Akt-mTOR Signaling Pathway in Human Acute Myeloid Leukemia (AML) Cells

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Making synaptic plasticity and memory last: mechanisms of translational regulationPreprint

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FKBP Family Proteins: Immunophilins with Versatile Biological Functions

Kang, C., Ye, H., Dhe‐Paganon, S., & Yoon, H. S. (2008) · Neurosignals · doi:10.1159/000123041 · Cited by 331 · see citing works

Regulation of Tissue Growth through Nutrient Sensing

Hietakangas, V., & Cohen, S. M. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134815 · Cited by 329 · see citing works

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

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mTOR and the control of whole body metabolism

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Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia

Park, S., Chapuis, N., Tamburini, J., Bardet, V., Cornillet‐Lefèbvre, P., Willems, L., Green, A. S., Mayeux, P., Lacombe, C., & Bouscary, D. (2009) · Haematologica · doi:10.3324/haematol.2009.013797 · Cited by 308 · see citing works

Rapamycin and Glucose-Target of Rapamycin (TOR) Protein Signaling in Plants

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Leucine and mTORC1: a complex relationship

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Protein Kinases and Phosphatases in the Control of Cell Fate

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Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s)

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L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia.

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Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status

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Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms

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Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death

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Regulation of PRKN-independent mitophagy

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Autophagy, lipophagy and lysosomal lipid storage disorders

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A comprehensive map of the mTOR signaling network

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Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

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Removal of FKBP12 Enhances mTOR-Raptor Interactions, LTP, Memory, and Perseverative/Repetitive Behavior

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Amino Acid Signaling in TOR Activation

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Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1

Rosner, M., & Hengstschläger, M. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn192 · Cited by 233 · see citing works

Metformin stimulates osteoprotegerin and reduces RANKL expression in osteoblasts and ovariectomized rats

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The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway

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Perifosine: Update on a novel Akt inhibitor

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Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells

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Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway

Martelli, A. M., Evangelisti, C., Chappell, W. H., Abrams, S. L., Bäsecke, J., Stivala, F., Donia, M., Fagone, P., Nicoletti, F., Libra, M., et al. (2011) · Leukemia · doi:10.1038/leu.2011.46 · Cited by 202 · see citing works

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders.

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The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation

Green, A. S., Chapuis, N., Trovati Maciel, T., Willems, L., Lambert, M., Arnoult, C., Boyer, O., Bardet, V., Park, S., Foretz, M., et al. (2010) · Blood · doi:10.1182/blood-2010-02-269837 · Cited by 199 · see citing works

Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein

Sato, T., Nakashima, A., Guo, L., & Tamanoi, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809207200 · Cited by 196 · see citing works

Glycolytic Flux Signals to mTOR through Glyceraldehyde-3-Phosphate Dehydrogenase-Mediated Regulation of Rheb

Lee, M. N., Ha, S. H., Kim, J. J., Koh, A., Lee, C. S., Kim, J. H., Jeon, H., Kim, D., Suh, P., & Ryu, S. H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00165-09 · Cited by 186 · see citing works

mTOR Signaling, Function, Novel Inhibitors, and Therapeutic Targets

Watanabe, R., Liu, W., & Huang, J. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.089623 · Cited by 186 · see citing works

The mTOR pathway and its role in human genetic diseases

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Integrating Body and Organ Size in Drosophila: Recent Advances and Outstanding Problems

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Phospholipase D1 is an effector of Rheb in the mTOR pathway

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Regulation of Body Size and Growth Control

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Characterization of TCTP, the Translationally Controlled Tumor Protein, fromArabidopsis thaliana

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Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle

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Regulation and Function of Protein Kinases and Phosphatases

Cheng, H.-C., Qi, R., Paudel, H., & Zhu, H.-J. (2011) · Enzyme Research · doi:10.4061/2011/794089 · Cited by 147 · see citing works

HER3 Is a Determinant for Poor Prognosis in Melanoma

Reschke, M., Mihic‐Probst, D., van der Horst, E. H., Knyazev, P. G., Wild, P. J., Hutterer, M., Meyer, S., Dummer, R., Moch, H., & Ullrich, A. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0186 · Cited by 168 · see citing works

Site-Specific mTOR Phosphorylation Promotes mTORC1-Mediated Signaling and Cell Growth

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The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia

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The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord

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Dual Inhibition of PI3K and mTORC1/2 Signaling by NVP-BEZ235 as a New Therapeutic Strategy for Acute Myeloid Leukemia

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Mammalian Target of Rapamycin: Hitting the Bull′s‐Eye for Neurological Disorders

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Atg5 Regulates Phenethyl Isothiocyanate-induced Autophagic and Apoptotic Cell Death in Human Prostate Cancer Cells

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Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

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The complexes of mammalian target of rapamycin

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Positioning mitochondrial plasticity within cellular signaling cascades

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mTORC1 signaling: what we still don't know

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Large FK506-binding proteins shape the pharmacology of rapamycin

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Roles of mTOR Signaling in Tissue Regeneration

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