Cytoprotective, antihyperglycemic and phytochemical properties of Cocos nucifera (L.) inflorescence
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OBJECTIVE: To analyze the cytoprotective and antidiabetic activities as well as phytochemical composition of the immature inflorescence of Cocos nucifera belonging to the Arecaceae Family. METHODS: The phytochemical screening of inflorescence was done to determine the major constituents present in Cocos nucifera inflorescence. The free radical scavenging potential of inflorescence extracts were evaluated using in vitro radical scavenging assay models. RESULTS: The phytochemical analyses on inflorescence showed the presence of phenolic compounds, flavonoids, resins and alkaloids. The macronutrient analyses, on the other hand, showed the presence of carbohydrate, proteins and fibers. Administration of the methanol extract of coconut inflorescence to the diabetic rats showed dose dependent reduction in hyperglycemia. The cytoprotective property of coconut inflorescence was evidenced from the acute toxicological evaluation. The levels of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase were significantly decreased in the diabetic rats treated with inflorescence when compared with the diabetic control rats. CONCLUSION: The results obtained from the present study apparently proved the non-toxic nature and the cytoprotective and antihyperglycemic properties of coconut inflorescence.
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The 200 mg/kg body weight dose showed better antihyperglycemic effects than other doses.
“The 200 mg/kg body weight dose showed better antihyperglycemic effects than other doses.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [72]
Administering immature coconut inflorescence methanol extract (West Coast Tall variety) to diabetic rats significantly reduced fasting glucose levels and increased insulin levels compared with a diabetic control.
“Administering immature coconut inflorescence methanol extract (West Coast Tall variety) to diabetic rats significantly reduced fasting glucose levels and increased insulin levels compared with a diabetic control (72).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [72]
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- Authors
- Renjith, R., Chikku, A., & Rajamohan, T.
- Affiliations
- University of Kerala (IN)
- Corresponding author
- Rajamohan, T
- Venue
- Asian Pacific Journal of Tropical Medicine
- Publisher
- Medknow
- Published
- 2013-10
- Volume
- 6
- Issue
- 10
- Pages
- 804-810
- ISSN
- 1995-7645 (ISSN-L)
- OpenAlex
- W2014924965
- Cited by
- 44
- References
- 38
- Citations by year
- 2026: 3 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 1
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Asian Pacific Journal of Tropical Medicine (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Asian Pacific Journal of Tropical Medicine
- Funders
- Kerala State Council for Science, Technology and Environment
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Cocos nucifera, antidiabetic activity, cytoprotection, phytochemical composition, free radical scavenging, antioxidant activity, diabetic rats, hepatoprotection, acute toxicity, phenolic compounds, flavonoids, methanol extract
- MeSH terms
- Alanine Transaminase, Animals, Aspartate Aminotransferases, Cocos, Diabetes Mellitus, Experimental, Humans, Hyperglycemia, Hypoglycemic Agents, Male, Plant Extracts, Rats, Sprague-Dawley, Protective Agents, Rats, Inflorescence
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