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Protective and curative effects of Cocos nucifera inflorescence on alloxan-induced pancreatic cytotoxicity in rats
Open accessAbstract
OBJECTIVES: This study was planned to investigate the effects of pre and post-treatment of young inflorescence of Cocos nucifera (CnI) on alloxan-induced diabetic rats. MATERIALS AND METHODS: Male albino Sprague Dawely rats were divided into five groups of six animals each. Group I was normal control, Group II was diabetic control, Cocos nucifera Inflorescence (CnI) was fed along with diet [20% (w/w)] orally (Group III) for a period of 11 days prior to alloxan injection (150 mg/kg i.p.). The curative effect of CnI was evaluated at the same feeding levels in alloxan-induced diabetic rats (Group IV) for a period of 30 days. The effects of both pretreatment and post-treatment (Group V) were also evaluated. Biochemical parameters such serum glucose, hepatic glycogen, and enzymes involving carbohydrate metabolism (hexokinase, phosphoglucomutase, pyruvate kinase, glucose-6-phosphatase, fructose 1, 6-diphosphatase, glucose-6 phosphate dehydrogenase, and glycogen phosphorylase) were assayed along with pancreatic histopathology. Data were analyzed using one-way analysis of variance followed by Duncan's post hoc multiple variance test. P < 0.05 was considered statistical significant. RESULTS: Diabetic control rats showed significant increase in serum glucose (P < 0.05) and decrease in hepatic glycogen levels (P < 0.05) compared to normal rats, which was reversed to near normal in both CnI pretreated and post-treated rats. Treatment with CnI resulted in significant decrease (P < 0.05) in activities of gluconeogenic enzymes in Group III and IV on compared to the diabetic control group, while glycolytic enzyme activities were improved in these groups. The cytotoxicity of pancreatic islets also ameliorated by treatment with CnI on histopathological examination. CONCLUSION: The results obtained in the study indicate the protective and curative effects of CnI on alloxan-induced pancreatic cytotoxicity, which is mediated through the regulation of carbohydrate metabolic enzyme activities and islets cell repair.
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Young coconut inflorescence promotes repair and rejuvenation of the residual β-cell population in diabetic rats.
“Young coconut inflorescence has been reported to protect against alloxan-induced pancreatic cytotoxicity and severe hyperglycemia, promoting the repair and rejuvenation of the residual β-cell population in diabetic rats [166, 167].”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [166]
Young coconut inflorescence protects against alloxan-induced pancreatic cytotoxicity and severe hyperglycemia in diabetic rats.
“Young coconut inflorescence has been reported to protect against alloxan-induced pancreatic cytotoxicity and severe hyperglycemia, promoting the repair and rejuvenation of the residual β-cell population in diabetic rats [166, 167].”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [166]
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Metadata
- Authors
- Rajamohan, T., & Renjith, R.
- Affiliations
- University of Kerala (IN)
- Corresponding author
- Rajamohan, Thankappan
- ORCID
- Renjith, RaveendranS
- Venue
- Indian Journal of Pharmacology
- Published
- 2012
- Volume
- 44
- Issue
- 5
- Pages
- 555
- ISSN
- 0253-7613 (ISSN-L)
- PMC
- PMC3480783
- OpenAlex
- W2053507302
- Cited by
- 22
- References
- 22
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 5 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 1
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- Indian Journal of Pharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Kerala State Council for Science, Technology and Environment
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Coconut Research and Applications
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- Cocos nucifera, alloxan-induced diabetes, type 1 diabetes, carbohydrate metabolism enzymes, gluconeogenic enzymes, glycolytic enzymes, liver glycogen, serum glucose, antidiabetic phytotherapy
- MeSH terms
- Alloxan, Animals, Cocos, Cytotoxins, Diabetes Mellitus, Experimental, Male, Pancreas, Plant Extracts, Random Allocation, Treatment Outcome, Rats, Sprague-Dawley, Protective Agents, Rats
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