The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease
Open accessAbstract
Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas. After a two-phase internal review process, a final list of 98 research topics was scored by 48 experts. Patients with pre-existing or post-COVID-19 airways disease contributed to the exercise by weighting selected criteria. The highest-ranked research idea focused on investigation of the relationship between prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge in patients with and without pre-existing airways disease. High priority was also assigned to comparisons of the prevalence and severity of post-COVID-19 fatigue, sarcopenia, anxiety, depression, and risk of future cardiovascular complications in patients with and without pre-existing airways disease. Our approach has enabled development of a set of priorities that could inform future research studies and funding decisions. This prioritisation process could also be adapted to other, non-respiratory aspects of long COVID.
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Post-covid syndrome is characterized by several symptoms affecting quality of life.
“This is typically referred to as a post-covid syndrome, characterized by several symptoms affecting quality of life (1–5).”
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- Authors
- Adeloye, D., Elneima, O., Daines, L., Poinasamy, K., Quint, J. K., Walker, S., Brightling, C. E., Siddiqui, S., Hurst, J. R., Chalmers, J. D., Pfeffer, P. E., Novotny, P., Drake, T. M., Heaney, L. G., Rudan, I., Sheikh, A., De Soyza, A., Adeloye, D., Elneima, O., Daines, L., Poinasamy, K., Quint, J. K., Walker, S., Brightling, C. E., Siddiqui, S., Hurst, J. R., Chalmers, J. D., Pfeffer, P. E., Novotny, P., Drake, T. M., Abdollahi, M., Agarwal, D., Al-Lehebi, R., Barnes, P. J., Bayry, J., Bonay, M., Bont, L. J., Bourdin, A., Brown, T., Caramori, G., Chan, A. H. Y., Dockrell, D. H., Doe, S., Duckers, J., D'Urzo, A., Ekström, M., Esteban, C., Greene, C. M., Gupta, A., Ingram, J. L., Khoo, E. M., Ko, F. W. S., Koppelman, G. H., Lipworth, B. J., Lisspers, K., Loebinger, M., Lopez-Campos, J. L., Maddocks, M., Mannino, D., Martinez-Garcia, M. A., Mcnamara, R., Miravitlles, M., Ndarukwa, P., Pooler, A., Rhee, C. K., Schwarz, P., Shaw, D., Steiner, M., Tai, A., Ulrik, C. S., Walker, P., Williams, M. C., Heaney, L. G., Rudan, I., Sheikh, A., & De Soyza, A.
- Affiliations
- Inserm (FR)
- University of Edinburgh (GB)
- Asthma + Lung UK (GB)
- ORCID
- Abdollahi, Mohammad
- Agarwal, Dhiraj
- Al-Lehebi, Riyad
- Barnes, Peter J
- Bayry, Jagadeesh
- Bonay, Marcel
- Bont, Louis J
- Bourdin, Arnaud
- Brown, Thomas
- Caramori, Gaetano
- Chan, Amy Hai Yan
- Dockrell, David H
- Doe, Simon
- Duckers, Jamie
- Ekström, Magnus
- Esteban, Cristóbal
- Greene, Catherine M
- Gupta, Atul
- Ingram, Jennifer L
- Khoo, Ee Ming
- Ko, Fanny Wai San
- Koppelman, Gerard H
- Lipworth, Brian J
- Lisspers, Karin
- Loebinger, Michael
- Maddocks, Matthew
- Mannino, David
- Mcnamara, Renae
- Miravitlles, Marc
- Ndarukwa, Pisirai
- Rhee, Chin Kook
- Schwarz, Peter
- Shaw, Dominick
- Steiner, Michael
- Tai, Andrew
- Ulrik, Charlotte Suppli
- Walker, Paul
- Williams, Michelle C
- Venue
- The Lancet Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 9
- Issue
- 12
- Pages
- 1467-1478
- ISSN
- 2213-2600 (ISSN-L)
- PMC
- PMC8372501
- OpenAlex
- W3195955915
- Cited by
- 126
- References
- 34
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 26 · 2023: 33 · 2022: 44 · 2021: 9
- FWCI
- 14.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The Lancet Respiratory Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion, other-oa)
- HAL (submittedVersion, cc-by)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by-nc-nd)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- NIHR Leicester Biomedical Research Centre
- Department of Health and Social Care
- British Lung Foundation
- AstraZeneca
- Asthma UK
- UK Research and Innovation
- University of Leicester
- Loughborough University (ISRCTN10980107)
- National Institute for Health and Care Research
- Medical Research Council
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- long COVID, airway disease, research priorities, post-COVID-19 fatigue, sarcopenia, anxiety, depression, cardiovascular complications, prognostic score
- MeSH terms
- COVID-19, SARS-CoV-2, Post-Acute COVID-19 Syndrome, Humans, Research, Respiration Disorders, Consensus
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