‘Long-COVID’: a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19
Open accessAbstract
Large numbers of people are being discharged from hospital following COVID-19 without assessment of recovery. In 384 patients (mean age 59.9 years; 62% male) followed a median 54 days post discharge, 53% reported persistent breathlessness, 34% cough and 69% fatigue. 14.6% had depression. In those discharged with elevated biomarkers, 30.1% and 9.5% had persistently elevated d-dimer and C reactive protein, respectively. 38% of chest radiographs remained abnormal with 9% deteriorating. Systematic follow-up after hospitalisation with COVID-19 identifies the trajectory of physical and psychological symptom burden, recovery of blood biomarkers and imaging which could be used to inform the need for rehabilitation and/or further investigation.
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Lower rates of depression (15 percent) have been reported after hospitalization for COVID-19.
“whereas lower rates of depression (15 percent) also have been reported after hospitalization for COVID-19 (8).”
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- Authors
- Mandal, S., Barnett, J., Brill, S. E., Brown, J. S., Denneny, E. K., Hare, S. S., Heightman, M., Hillman, T. E., Jacob, J., Jarvis, H. C., Lipman, M. C. I., Naidu, S. B., Nair, A., Porter, J. C., Tomlinson, G. S., & Hurst, J. R.
- Affiliations
- Royal Free London NHS Foundation Trust (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- University College Hospital (GB)
- Corresponding author
- Hurst, John R
- ORCID
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2020-11-10
- Volume
- 76
- Issue
- 4
- Pages
- 396-398
- ISSN
- 0040-6376 (ISSN-L)
- 1468-3296
- PMC
- PMC7615158
- OpenAlex
- W3101401355
- Cited by
- 864
- References
- 7
- Citations by year
- 2026: 18 · 2025: 50 · 2024: 111 · 2023: 181 · 2022: 263 · 2021: 235 · 2020: 6
- FWCI
- 74.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (Z/17/Z, 209553, 209553/Z/17/Z)
- National Institute for Health and Care Research
- University College London Hospitals NHS Foundation Trust
- Medical Research Council (MR/N007727/1)
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- long COVID, persistent symptoms, dyspnea, cough, fatigue, depression, D-dimer, C-reactive protein, biomarkers, chest X-ray abnormalities, post-discharge follow-up, rehabilitation
- MeSH terms
- COVID-19, SARS-CoV-2, Cross-Sectional Studies, Diagnostic Imaging, Female, Hospitalization, Humans, Lung, Male, Middle Aged, Severity of Illness Index, Biomarkers, Pandemics
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