Cited by 864Long-Term Effects of COVID-19COVID-19 Clinical Research StudiesCOVID-19 and Mental Health

‘Long-COVID’: a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19

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Mandal, Swapna, Barnett, Joseph, Brill, Simon E, Brown, Jeremy S, Denneny, Emma K, Hare, Samanjit S, Heightman, Melissa, Hillman, Toby E +8 more·2021·Thorax

Abstract

Large numbers of people are being discharged from hospital following COVID-19 without assessment of recovery. In 384 patients (mean age 59.9 years; 62% male) followed a median 54 days post discharge, 53% reported persistent breathlessness, 34% cough and 69% fatigue. 14.6% had depression. In those discharged with elevated biomarkers, 30.1% and 9.5% had persistently elevated d-dimer and C reactive protein, respectively. 38% of chest radiographs remained abnormal with 9% deteriorating. Systematic follow-up after hospitalisation with COVID-19 identifies the trajectory of physical and psychological symptom burden, recovery of blood biomarkers and imaging which could be used to inform the need for rehabilitation and/or further investigation.

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Authors
Mandal, S., Barnett, J., Brill, S. E., Brown, J. S., Denneny, E. K., Hare, S. S., Heightman, M., Hillman, T. E., Jacob, J., Jarvis, H. C., Lipman, M. C. I., Naidu, S. B., Nair, A., Porter, J. C., Tomlinson, G. S., & Hurst, J. R.
Affiliations
  • Royal Free London NHS Foundation Trust (GB)
  • University College London Hospitals NHS Foundation Trust (GB)
  • University College Hospital (GB)
Corresponding author
Hurst, John R
Venue
Thorax
Publisher
BMJ
Published
2020-11-10
Volume
76
Issue
4
Pages
396-398
ISSN
  • 0040-6376 (ISSN-L)
  • 1468-3296
OpenAlex
W3101401355
Cited by
864
References
7
Citations by year
2026: 18 · 2025: 50 · 2024: 111 · 2023: 181 · 2022: 263 · 2021: 235 · 2020: 6
FWCI
74.15
Type
journal article
Language
en
Open access
Locations
  • Thorax (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Wellcome Trust (Z/17/Z, 209553, 209553/Z/17/Z)
  • National Institute for Health and Care Research
  • University College London Hospitals NHS Foundation Trust
  • Medical Research Council (MR/N007727/1)
Topics
  • Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
Keywords
long COVID, persistent symptoms, dyspnea, cough, fatigue, depression, D-dimer, C-reactive protein, biomarkers, chest X-ray abnormalities, post-discharge follow-up, rehabilitation
MeSH terms
COVID-19, SARS-CoV-2, Cross-Sectional Studies, Diagnostic Imaging, Female, Hospitalization, Humans, Lung, Male, Middle Aged, Severity of Illness Index, Biomarkers, Pandemics

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