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Cited by 134Sexual Differentiation and DisordersAdrenal Hormones and DisordersOvarian function and disorders

The DOI matches its Crossref record; 104 of the 108 references it cites were found in a registry or an index.

Management of adolescents with congenital adrenal hyperplasia

Open access
Merke, Deborah P, Poppas, Dix P·2013·The Lancet Diabetes & Endocrinology
DOI 10.1016/s2213-8587(13)70138-4PMC PMC4163910
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Abstract

The management of congenital adrenal hyperplasia involves suppression of adrenal androgen production, in addition to treatment of adrenal insufficiency. Management of adolescents with congenital adrenal hyperplasia is especially challenging because changes in the hormonal milieu during puberty can lead to inadequate suppression of adrenal androgens, psychosocial issues often affect adherence to medical therapy, and sexual function plays a major part in adolescence and young adulthood. For these reasons, treatment regimen reassessment is indicated during adolescence. Patients with non-classic congenital adrenal hyperplasia require reassessment regarding the need for glucocorticoid drug treatment. No clinical trials have compared various regimens for classic congenital adrenal hyperplasia in adults, thus therapy is individualised and based on the prevention of adverse outcomes. Extensive patient education is key during transition from paediatric care to adult care and should include education of females with classic congenital adrenal hyperplasia regarding their genital anatomy and surgical history. Common issues for these patients include urinary incontinence, vaginal stenosis, clitoral pain, and cosmetic concerns; for males with classic congenital adrenal hyperplasia, common issues include testicular adrenal rest tumours. Transition from paediatric to adult care is most successful when phased over many years. Education of health-care providers on how to successfully transition patients is greatly needed.

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Metadata

Authors
Merke, D. P., & Poppas, D. P.
Affiliations
  • National Institutes of Health (US)
  • NewYork–Presbyterian Hospital (US)
Corresponding author
Merke, Deborah P
ORCID
Merke, Deborah P
Venue
The Lancet Diabetes & Endocrinology
Publisher
Elsevier BV
Published
2013-12
Volume
1
Issue
4
Pages
341-352
ISSN
2213-8587 (ISSN-L)
DOI
10.1016/s2213-8587(13)70138-4
PMC
PMC4163910
OpenAlex
W2149437278
Cited by
134
References
108
Citations by year
2026: 6 · 2025: 6 · 2024: 12 · 2023: 11 · 2022: 30 · 2021: 13 · 2020: 6 · 2019: 11 · 2018: 12 · 2017: 11 · 2016: 8 · 2015: 6
FWCI
0.44
Type
journal article
Language
en
Open access
Locations
  • The Lancet Diabetes & Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (Z99CL999999)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
congenital adrenal hyperplasia, adolescents, puberty, androgen deprivation therapy, glucocorticoid therapy, non-classical congenital adrenal hyperplasia, adrenal insufficiency, medication adherence, sexual function, transition to adult care, patient education, urinary incontinence, vaginal stenosis, clitoral pain, personalized treatment
MeSH terms
Adolescent, Adrenal Hyperplasia, Congenital, Glucocorticoids, Humans, Disease Management

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