Liothyronine cost and prescriptions in England
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In the United Kingdom, there is a 49-fold variation in the number of liothyronine prescriptions per 1000 levothyroxine prescriptions by local prescribing region.
“At present in the United Kingdom, there is a 49 -fold variation in the number of liothyronine prescriptions per 1000 levothyroxine prescriptions by local prescribing region. 47”
From Use of liothyronine (T3) in hypothyroidism: Joint British Thyroid Association/Society for endocrinology consensus statement (2023) · cites this paper as [47]
The Correspondence (p. 2) analyzes prescribing across 195 local clinical commissioning groups in England and reports widespread variability in access. The figure caption (p. 1) uses liothyronine prescriptions per 1000 levothyroxine prescriptions, but our copy does not give a 49-fold regional variation; it also studies England rather than the United Kingdom as a whole. (LLM, conf=0.86)
Experimental — accuracy not yet measuredA UK study highlighted the current gaps in understanding, where there was a 49-fold variation in the number of liothyronine prescriptions per 1000 levothyroxine prescriptions by local prescribing region.
“A UK study highlighted the current gaps in understanding, where there was a 49-fold variation in the number of liothyronine prescriptions per 1000 levothyroxine prescriptions by local prescribing region.185”
From Hypothyroidism (2024) · cites this paper as [185]
The Correspondence (p. 2) analyses liothyronine prescriptions across 195 local clinical commissioning groups and reports widespread variability in patients’ access. The figure caption (p. 1) uses prescriptions per 1,000 levothyroxine prescriptions, but our copy does not report the claimed 49-fold regional variation. (LLM, conf=0.84)
Experimental — accuracy not yet measured
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Cites
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Self-citation2012 ETA Guidelines: The Use of L-T4 + L-T3 in the Treatment of Hypothyroidism
Wiersinga, W. M., Duntas, L., Fadeyev, V., Nygaard, B., & Vanderpump, M. P. J. (2012) · European Thyroid Journal · doi:10.1159/000339444 · Cited by 427 · see citing works
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Self-citationSaravanan, P., Simmons, D. J., Greenwood, R., Peters, T. J., & Dayan, C. M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1672 · Cited by 136 · see citing works
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Research works printed but not linked: 1
- 6 OpenPrescribing.net. EBM DataLab, University of Oxford, 2018. https:// openprescribing.net/chemical/0602010M0/ (accessed Oct 1, 2018).
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Jonklaas, J., Bianco, A. C., Cappola, A. R., Celi, F. S., Fliers, E., Heuer, H., McAninch, E. A., Moeller, L. C., Nygaard, B., Sawka, A. M., et al. (2021) · Thyroid® · doi:10.1089/thy.2020.0720 · Cited by 172 · see citing works
Self-citationTaylor, P. N., Medici, M. M., Hubalewska-Dydejczyk, A., & Boelaert, K. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01614-3 · Cited by 128 · see citing works
Self-citationOptimal thyroid hormone replacement
Jonklaas, J. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab031 · Cited by 89 · see citing works
Mitchell, A. L., Hegedüs, L., Žarković, M., Hickey, J. L., & Perros, P. (2021) · Clinical Endocrinology · doi:10.1111/cen.14340 · Cited by 81 · see citing works
Jonklaas, J., Bianco, A. C., Cappola, A. R., Celi, F. S., Fliers, E., Heuer, H., McAninch, E. A., Moeller, L. C., Nygaard, B., Sawka, A. M., et al. (2021) · European Thyroid Journal · doi:10.1159/000512970 · Cited by 78 · see citing works
Self-citationLiothyronine Use in Hypothyroidism and its Effects on Cancer and Mortality
Planck, T., Hedberg, F., Calissendorff, J., & Nilsson, A. (2021) · Thyroid® · doi:10.1089/thy.2020.0388 · Cited by 35 · see citing works
Ahluwalia, R., Baldeweg, S. E., Boelaert, K., Chatterjee, K., Dayan, C., Okosieme, O., Priestley, J., Taylor, P., Vaidya, B., Zammitt, N., et al. (2023) · Clinical Endocrinology · doi:10.1111/cen.14935 · Cited by 34 · see citing works
“in the number of liothyronine prescriptions per 1000 levothyroxine prescriptions by local prescribing region.(47) A substantial driver of this has been the dramatic price rise in liothyronine in the United Kingdom, leading to local NHS medicine management policies,”
BackgroundSelf-citationYounes, Y. R., Perros, P., Hegedüs, L., Papini, E., Nagy, E. V., Attanasio, R., Negro, R., & Field, B. C. T. (2023) · Clinical Endocrinology · doi:10.1111/cen.14812 · Cited by 19 · see citing works
Trends in costs and prescribing for liothyronine and levothyroxine in England and wales 2011–2020
Stedman, M., Taylor, P., Premawardhana, L., Okosieme, O., Dayan, C., & Heald, A. H. (2021) · Clinical Endocrinology · doi:10.1111/cen.14414 · Cited by 16 · see citing works
Self-citationBahl, S., Taylor, P. N., Premawardhana, L. D., Stedman, M., Heald, A., Dayan, C. M., & Okosieme, O. E. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf449 · Cited by 11 · see citing works
“LT4 is now the third most prescribed medication in the UK and is likely to become even more widely used in the future (7).”
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- Authors
- Taylor, P. N., Razvi, S., Muller, I., Wass, J., Dayan, C. M., Chatterjee, K., & Boelaert, K.
- Affiliations
- Cardiff University (GB)
- Gateshead Health NHS Foundation Trust (GB)
- Churchill Hospital (GB)
- Addenbrooke's Hospital (GB)
- University of Birmingham (GB)
- Corresponding author
- Taylor, Peter N
- ORCID
- Venue
- The Lancet Diabetes & Endocrinology
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 7
- Issue
- 1
- Pages
- 11-12
- ISSN
- 2213-8587 (ISSN-L)
- OpenAlex
- W2903673236
- Cited by
- 19
- References
- 4
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 2
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet Diabetes & Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, cc-by-nc-nd)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Newcastle University ePrints (Newcastle Univesity) (cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
- Keywords
- liothyronine, levothyroxine, hypothyroidism, drug costs, prescribing patterns, combination thyroid hormone therapy, patient dissatisfaction, England, health care costs, genetic polymorphism
- MeSH terms
- England, Humans, Hypothyroidism, Drug Prescriptions, Receptors, Thyroid Hormone, Triiodothyronine, Drug Costs
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