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Cited by 903

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

COVID-19 in people with diabetes: understanding the reasons for worse outcomes

Open access
Apicella, Matteo, Campopiano, Maria Cristina, Mantuano, Michele, Mazoni, Laura, Coppelli, Alberto, Del Prato, Stefano·2020·The Lancet Diabetes & Endocrinology

Abstract

Since the initial COVID-19 outbreak in China, much attention has focused on people with diabetes because of poor prognosis in those with the infection. Initial reports were mainly on people with type 2 diabetes, although recent surveys have shown that individuals with type 1 diabetes are also at risk of severe COVID-19. The reason for worse prognosis in people with diabetes is likely to be multifactorial, thus reflecting the syndromic nature of diabetes. Age, sex, ethnicity, comorbidities such as hypertension and cardiovascular disease, obesity, and a pro-inflammatory and pro-coagulative state all probably contribute to the risk of worse outcomes. Glucose-lowering agents and anti-viral treatments can modulate the risk, but limitations to their use and potential interactions with COVID-19 treatments should be carefully assessed. Finally, severe acute respiratory syndrome coronavirus 2 infection itself might represent a worsening factor for people with diabetes, as it can precipitate acute metabolic complications through direct negative effects on β-cell function. These effects on β-cell function might also cause diabetic ketoacidosis in individuals with diabetes, hyperglycaemia at hospital admission in individuals with unknown history of diabetes, and potentially new-onset diabetes.

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Metadata

Authors
Apicella, M., Campopiano, M. C., Mantuano, M., Mazoni, L., Coppelli, A., & Del Prato, S.
Venue
The Lancet Diabetes & Endocrinology
Publisher
Elsevier BV
Published
2020-09
Volume
8
Issue
9
Pages
782-792
ISSN
2213-8587 (ISSN-L)
OpenAlex
W3042557581
Cited by
903
References
16
FWCI
23.45
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: COVID-19 in people with diabetes: understanding the reasons for worse outcomes. https://app.cochat.ai/papers/10.1016/s2213-8587(20)30238-2
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Apicella, M., Campopiano, M. C., Mantuano, M., Mazoni, L., Coppelli, A., & Del Prato, S. (2020). COVID-19 in people with diabetes: understanding the reasons for worse outcomes. The Lancet Diabetes & Endocrinology. https://doi.org/10.1016/s2213-8587(20)30238-2

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.