The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Global mortality variations in patients with heart failure: results from the International Congestive Heart Failure (INTER-CHF) prospective cohort study
Open accessAbstract
BACKGROUND: Most data on mortality and prognostic factors in patients with heart failure come from North America and Europe, with little information from other regions. Here, in the International Congestive Heart Failure (INTER-CHF) study, we aimed to measure mortality at 1 year in patients with heart failure in Africa, China, India, the Middle East, southeast Asia and South America; we also explored demographic, clinical, and socioeconomic variables associated with mortality. METHODS: We enrolled consecutive patients with heart failure (3695 [66%] clinic outpatients, 2105 [34%] hospital in patients) from 108 centres in six geographical regions. We recorded baseline demographic and clinical characteristics and followed up patients at 6 months and 1 year from enrolment to record symptoms, medications, and outcomes. Time to death was studied with Cox proportional hazards models adjusted for demographic and clinical variables, medications, socioeconomic variables, and region. We used the explained risk statistic to calculate the relative contribution of each level of adjustment to the risk of death. FINDINGS: We enrolled 5823 patients within 1 year (with 98% follow-up). Overall mortality was 16·5%: highest in Africa (34%) and India (23%), intermediate in southeast Asia (15%), and lowest in China (7%), South America (9%), and the Middle East (9%). Regional differences persisted after multivariable adjustment. Independent predictors of mortality included cardiac variables (New York Heart Association Functional Class III or IV, previous admission for heart failure, and valve disease) and non-cardiac variables (body-mass index, chronic kidney disease, and chronic obstructive pulmonary disease). 46% of mortality risk was explained by multivariable modelling with these variables; however, the remainder was unexplained. INTERPRETATION: Marked regional differences in mortality in patients with heart failure persisted after multivariable adjustment for cardiac and non-cardiac factors. Therefore, variations in mortality between regions could be the result of health-care infrastructure, quality and access, or environmental and genetic factors. Further studies in large, global cohorts are needed. FUNDING: The study was supported by Novartis.
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Cites
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
Peduzzi, P., Concato, J., Feinstein, A. R., & Holford, T. R. (1995) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(95)00048-8 · Cited by 2,154
Wang, H., Dwyer-Lindgren, L., Lofgren, K. T., Rajaratnam, J. K., Marcus, J. R., Levin-Rector, A., Levitz, C. E., Lopez, A. D., & Murray, C. J. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61719-x · Cited by 810
Crespo-Leiro, M. G., Anker, S. D., Maggioni, A. P., Coats, A. J., Filippatos, G., Ruschitzka, F., Ferrari, R., Piepoli, M. F., Delgado Jimenez, J. F., Metra, M., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.566 · Cited by 798
Cited by
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300
Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Alonso, A., Beaton, A. Z., Bittencourt, M. S., Boehme, A. K., Buxton, A. E., Carson, A. P., Commodore-Mensah, Y., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001052 · Cited by 5,987
Groenewegen, A., Rutten, F. H., Mosterd, A., & Hoes, A. W. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1858 · Cited by 2,043
Wang, K., Tian, J., Zheng, C., Yang, H., Ren, J., Liu, Y., Han, Q., & Zhang, Y. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104813 · Cited by 361
Rossignol, P., Hernandez, A. F., Solomon, S. D., & Zannad, F. (2019) · The Lancet · doi:10.1016/s0140-6736(18)31808-7 · Cited by 316
Metadata
- Authors
- Dokainish, H., Teo, K., Zhu, J., Roy, A., AlHabib, K. F., ElSayed, A., Palileo-Villaneuva, L., Lopez-Jaramillo, P., Karaye, K., Yusoff, K., Orlandini, A., Sliwa, K., Mondo, C., Lanas, F., Prabhakaran, D., Badr, A., Elmaghawry, M., Damasceno, A., Tibazarwa, K., Belley-Cote, E., Balasubramanian, K., Islam, S., Yacoub, M. H., Huffman, M. D., Harkness, K., Grinvalds, A., McKelvie, R., Bangdiwala, S. I., Yusuf, S., Campos, R., Chacón, C., Cursack, G., Diez, F., Escobar, C., Garcia, C., Vilamajo, O. G., Hominal, M., Ingaramo, A., Kucharczuk, G., Pelliza, M., Rojas, A., Villani, A., Zapata, G., Bourke, P., Lanas, F., Nahuelpan, L., Olivares, C., Riquelme, R., Ai, F., Bai, X., Chen, X., Chen, Y., Gao, M., Ge, C., He, Y., Huang, W., Jiang, H., Liang, T., Liang, X., Liao, Y., Liu, S., Luo, Y., Lu, L., Qin, S., Tan, G., Tan, H., Wang, T., Wang, X., Wei, F., Xiao, F., Zhang, B., Zheng, T., Mendoza, J. L. A., Anaya, M. B., Gomez, E., de Salazar, D. I. M., Quiroz, F., Rodríguez, M. J., Sotomayor, M. S., Navas, A. T., León, M. B., Montalvo, L. A. F., Jaramillo, M. L., Patiño, E. P., Perugachi, C., Trujillo Cruz, F., Elmaghawry, M., Wagdy, K., Bhardwaj, A. K., Chaturvedi, V., Gokhale, G. K., Gupta, R., Honnutagi, R., Joshi, P., Ladhani, S., Negi, P. C., Roy, A., Reddy, N., Abdullah, A., Hassan, M. R. A., Balasinga, M., Kasim, S., Tan, W. Y., Yusoff, K., Damasceno, A., Banze, R., Calua, E., Novela, C., Chemane, J., Akintunde, A. A., Ansa, V., Gbadamosi, H., Karaye, K. M., Mbakwem, A., Mohammed, S., Nwafor, E., Ojji, D., Olunuga, T., Sa'idu, B. O. H., Umuerri, E., Alcaraz, J., Palileo-Villanueva, L., Palomares, E., Timonera, M. R., Badr, A., Alghamdi, S., Alhabib, K., Almasood, A., Alsaif, S., Elasfar, A., Ghabashi, A., Mimish, L., Bester, F., Kelbe, D., Klug, E., Sliwa, K., Tibarzawa, K., Abdalla, O. E., Dimitri, M. E., Mustafa, H., Osman, O., Saad, A., & Mondo, C.
- Venue
- The Lancet Global Health
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 5
- Issue
- 7
- Pages
- e665-e672
- ISSN
- 2214-109X (ISSN-L)
- OpenAlex
- W2611250527
- Cited by
- 409
- References
- 4
- FWCI
- 23.01
- Type
- journal article
- Language
- en
- Open access
- gold
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