European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions
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Aims: The European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT-R) was set up with the aim of describing the clinical epidemiology and the 1-year outcomes of patients with heart failure (HF) with the added intention of comparing differences between participating countries. Methods and results: The ESC-HF-LT-R is a prospective, observational registry contributed to by 211 cardiology centres in 21 European and/or Mediterranean countries, all being member countries of the ESC. Between May 2011 and April 2013 it collected data on 12 440 patients, 40.5% of them hospitalized with acute HF (AHF) and 59.5% outpatients with chronic HF (CHF). The all-cause 1-year mortality rate was 23.6% for AHF and 6.4% for CHF. The combined endpoint of mortality or HF hospitalization within 1 year had a rate of 36% for AHF and 14.5% for CHF. All-cause mortality rates in the different regions ranged from 21.6% to 36.5% in patients with AHF, and from 6.9% to 15.6% in those with CHF. These differences in mortality between regions are thought reflect differences in the characteristics and/or management of these patients. Conclusion: The ESC-HF-LT-R shows that 1-year all-cause mortality of patients with AHF is still high while the mortality of CHF is lower. This registry provides the opportunity to evaluate the management and outcomes of patients with HF and identify areas for improvement.
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Each increment of 1 unit in the WATCH-DM risk score is associated with a 24% higher heart failure risk within 5 years.
“Each increment of 1 unit in the risk score is associated with a 24% higher HF risk within 5 years.”
From 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes. (2023) · cites this paper as [480]
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Self-citationMebazaa, A., Motiejūnaitė, J., Gayat, É., Crespo‐Leiro, M. G., Lund, L. H., Maggioni, A. P., Chioncel, O., Akiyama, E., Harjola, V., Seferovic, P. M., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.991 · Cited by 118 · see citing works
Self-citationWorld Heart Federation Roadmap for Heart Failure
Ferreira, J. P., Kraus, S., Mitchell, S., Perel, P., Piñeiro, D., Chioncel, O., Colque, R. M. A., de Boer, R. A., Gómez‐Mesa, J. E., Grancelli, H., et al. (2019) · Global Heart · doi:10.1016/j.gheart.2019.07.004 · Cited by 115 · see citing works
Self-citationImpact Analysis of Heart Failure Across European Countries: An ESC-HFA Position Paper
Rosano, G. M. C., Seferovic, P. M., Savarese, G., Spoletini, I., Lopatin, Y. M., Gustafsson, F., Bayés‐Genís, A., Jaarsma, T., Abdelhamid, M., González, A., et al. (2022) · ESC Heart Failure · doi:10.1002/ehf2.14076 · Cited by 113 · see citing works
Self-citationMetra, M., Adamo, M., Tomasoni, D., Mebazaa, A., Bayés‐Genís, A., Abdelhamid, M., Adamopoulos, S. N., Anker, S. D., Bauersachs, J. K., Belenkov, Y. N., et al. (2023) · European Journal of Heart Failure · doi:10.1002/ejhf.2888 · Cited by 107 · see citing works
Self-citationMicroRNAs in cardiovascular disease
Siasos, G., Bletsa, E., Stampouloglou, P. K., Oikonomou, E. K., Tsigkou, V., Paschou, S. Α., Vlasis, K. G., Marinos, G., Vavuranakis, M., Stefanadis, C., et al. (2020) · Hellenic Journal of Cardiology · doi:10.1016/j.hjc.2020.03.003 · Cited by 104 · see citing works
Self-citationSavarese, G., Lindberg, F., Cannata, A. N., Chioncel, O., Stolfo, D., Musella, F., Tomasoni, D., Abdelhamid, M., Banerjee, D., Bayés‐Genís, A., et al. (2024) · European Journal of Heart Failure · doi:10.1002/ejhf.3295 · Cited by 100 · see citing works
Self-citationGender-Related Factors in Medication Adherence for Metabolic and Cardiovascular Health
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Heart Failure Around the World
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van der Velden, J., Asselbergs, F. W., Bakkers, J., Batkai, S., Bertrand, L., Bezzina, C. R., Bot, I., Brundel, B. J. J. M., Carrier, L., Chamuleau, S. A. J., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvab370 · Cited by 88 · see citing works
Registry-Based Pragmatic Trials in Heart Failure: Current Experience and Future Directions
Lund, L. H., Oldgren, J., & James, S. K. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0325-0 · Cited by 89 · see citing works
Kapelios, C. J., Shahim, B., Lund, L., & Savarese, G. (2023) · Cardiac failure review · doi:10.15420/cfr.2023.03 · Cited by 79 · see citing works
Harjola, V., Parissis, J., Rocca, H. B., Čelutkienė, J., Chioncel, O., Collins, S. P., Backer, D. D., Filippatos, G. S., Gayat, É., Hill, L., et al. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1204 · Cited by 81 · see citing works
Self-citationFernández‐Pombo, A., Rodríguez-Carnero, G., Castro, A. I., Cantón-Blanco, A., Seoane, L. M., Casanueva, F. F., Crujeiras, A. B., & Olmos, M. Á. M. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.07.027 · Cited by 77 · see citing works
Updates in heart failure 30-day readmission prevention
Goldgrab, D., Balakumaran, K., Kim, M. J., & Tabtabai, S. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9754-4 · Cited by 75 · see citing works
Heart Failure Statistics 2024 Update: A Report From the Korean Society of Heart Failure
Lee, C. J., Lee, H., Yoon, M., Chun, K., Kong, M. G., Jung, M., Kim, I., Cho, J. Y., Kang, J., Park, J. J., et al. (2024) · International Journal of Heart Failure · doi:10.36628/ijhf.2024.0010 · Cited by 77 · see citing works
The Difference in Referencing in Web of Science, Scopus, and Google Scholar
Anker, M. S., Hadzibegovic, S., Lena, A., & Haverkamp, W. (2019) · ESC Heart Failure · doi:10.1002/ehf2.12583 · Cited by 82 · see citing works
Diagnosis of Acute Heart Failure in the Emergency Department: An Evidence-Based Review
Long, B., Koyfman, A., & Gottlieb, M. A. (2019) · Western Journal of Emergency Medicine · doi:10.5811/westjem.2019.9.43732 · Cited by 71 · see citing works
What Proportion of Patients with Chronic Heart Failure are Eligible for Sacubitril–Valsartan?
Pellicori, P., Urbinati, A., Shah, P. P., Macnamara, A., Kazmi, S., Dierckx, R., Zhang, J., Cleland, J. G. F., & Clark, A. L. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.788 · Cited by 70 · see citing works
Kapelios, C. J., Laroche, C., Crespo‐Leiro, M. G., Anker, S. D., Coats, A. J. S., Molina, B. D., Filippatos, G. S., Lainščak, M., Maggioni, A. P., McDonagh, T. A., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1796 · Cited by 69 · see citing works
Self-citationKintscher, U., Foryst‐Ludwig, A., Haemmerle, G., & Zechner, R. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100001 · Cited by 68 · see citing works
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Self-citationImpact of mitral regurgitation in patients with worsening heart failure: insights from BIOSTAT‐CHF
Pagnesi, M., Adamo, M., Sama, I. E., Anker, S. D., Cleland, J. G. F., Dickstein, K., Filippatos, G. S., Lang, C. C., Ng, L. L., Ponikowski, P. P., et al. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2276 · Cited by 69 · see citing works
Self-citationMultiparametric approach to congestion for predicting long-term survival in heart failure
Massari, F., Scicchitano, P., Iacoviello, M., Passantino, A., Guida, P., Sanasi, M., Piscopo, A., Romito, R., Valle, R., Caldarola, P., et al. (2019) · Journal of Cardiology · doi:10.1016/j.jjcc.2019.05.017 · Cited by 65 · see citing works
Ketone bodies for the failing heart: fuels that can fix the engine?
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Harikrishnan, S., Bahl, A., Roy, A., Mishra, A., Prajapati, J., Manjunath, C. N., Sethi, R., Guha, S., Satheesh, S., Dhaliwal, R. S., et al. (2022) · ESC Heart Failure · doi:10.1002/ehf2.14096 · Cited by 66 · see citing works
Heart Failure in the Outpatient Versus Inpatient Setting: Findings from the BIOSTAT-CHF Study
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Self-citationMalgie, J., Clephas, P. R. D., Rocca, H. B., de Boer, R. A., & Brugts, J. J. (2023) · Heart Failure Reviews · doi:10.1007/s10741-023-10325-2 · Cited by 69 · see citing works
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Digital Health: Implications for Heart Failure Management
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Chioncel, O., Benson, L., Crespo‐Leiro, M. G., Anker, S. D., Coats, A. J. S., Filippatos, G. S., McDonagh, T. A., Margineanu, C., Mebazaa, A., Metra, M., et al. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad151 · Cited by 61 · see citing works
Self-citationLi, L., Liu, R., Jiang, C., Du, X., Huffman, M. D., Lam, C. S. P., Patel, A. A., Hillis, G. S., Anderson, C. S., Ma, C., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1630 · Cited by 59 · see citing works
Aktaa, S., Polovina, M. M., Rosano, G. M. C., Abdin, A., Anguita, M. P., Lainščak, M., Lund, L. H., McDonagh, T. A., Metra, M., Mindham, R., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2371 · Cited by 59 · see citing works
Self-citationHariharaputhiran, S., Peng, Y., Ngo, L., Alı̀, A., Hossain, S., Visvanathan, R., Adams, R. J., Chan, W., & Ranasinghe, I. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2595 · Cited by 58 · see citing works
Ganapathi, S., Jeemon, P., Agarwal, A., Viswanathan, S. K., Sreedharan, M., Vijayaraghavan, G., Bahuleyan, C. G., Biju, R., Nair, T., Prathapkumar, N., et al. (2018) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2018.05.007 · Cited by 58 · see citing works
Therapeutic and Prognostic Significance of Arachidonic Acid in Heart Failure
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Self-citation2026 ESC Guidelines for the management of heart failure
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Self-citationHeart Failure In The Middle East Arab Countries: Current And Future Perspectives
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Crespo‐Leiro, M. G., & Barge‐Caballero, E. (2021) · Heart Failure Clinics · doi:10.1016/j.hfc.2021.06.002 · Cited by 55 · see citing works
Self-citationFilippatos, G. S., Anker, S. D., Butler, J., Farmakis, D. T., Ferreira, J. P., Gollop, N. D., Brueckmann, M., Iwata, T., Pocock, S., Zannad, F. M., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2707 · Cited by 58 · see citing works
Self-citationImplementing Guideline-Directed Medical Therapy for Heart Failure
Patolia, H. H., Khan, M. S., Fonarow, G. C., Butler, J., & Greene, S. J. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.03.430 · Cited by 55 · see citing works
Fatigue in heart failure outpatients: levels, associated factors, and the impact on quality of life
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Harikrishnan, S., Ganapathi, S., Agarwal, A., Kumar, N. P., Kumar, K. K., Bahuleyan, C. G., Vijayaraghavan, G., Viswanathan, S. K., Sreedharan, M., Biju, R., et al. (2017) · American Heart Journal · doi:10.1016/j.ahj.2017.03.019 · Cited by 54 · see citing works
Chinese Guidelines for the Diagnosis and Treatment of Heart Failure 2024
ZHANG, S.-Y. (2025) · 老年心脏病学杂志：英文版 · doi:10.26599/1671-5411.2025.03.002 · Cited by 59 · see citing works
Ponikowski, P. P., Kirwan, B., Anker, S. D., Dorobanţu, M., Dróżdż, J., Fabien, V., Filippatos, G. S., Haboubi, T., Keren, A., Khintibidze, I., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1710 · Cited by 54 · see citing works
Self-citationPölzl, G., Birgani, S. A., Colet, J. C., Delgado, J. F., Fedele, F., García‐Gonzáles, M. J., Gustafsson, F., Masip, J., Papp, Z., Störk, S., et al. (2018) · ESC Heart Failure · doi:10.1002/ehf2.12366 · Cited by 51 · see citing works
Tymińska, A., Ozierański, K., Balsam, P., Maciejewski, C., Wancerz, A., Brociek, E., Marchel, M., Crespo‐Leiro, M. G., Maggioni, A. P., Dróżdż, J., et al. (2022) · Biology · doi:10.3390/biology11020341 · Cited by 50 · see citing works
Self-citationCancer and Heart Failure—More than Meets the Eye: Common Risk Factors and Co-Morbidities
Anker, M. S., von Haehling, S., Landmesser, U., Coats, A. J. S., & Anker, S. D. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1252 · Cited by 50 · see citing works
Self-citationDrug Layering in Heart Failure
Rosano, G. M. C., Allen, L. A., Abdin, A., Lindenfeld, J. M., O’Meara, E., Lam, C. S. P., Lancellotti, P., Savarese, G., Gottlieb, S. S., Teerlink, J. R., et al. (2021) · JACC Heart Failure · doi:10.1016/j.jchf.2021.06.011 · Cited by 49 · see citing works
Zaman, S. U., Zaman, S., Scholtes, T., Shun-Shin, M. J., Plymen, C. M., Francis, D. P., & Cole, G. D. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.838 · Cited by 49 · see citing works
- Authors
- Crespo-Leiro, M. G., Anker, S. D., Maggioni, A. P., Coats, A. J., Filippatos, G., Ruschitzka, F., Ferrari, R., Piepoli, M. F., Delgado Jimenez, J. F., Metra, M., Fonseca, C., Hradec, J., Amir, O., Logeart, D., Dahlström, U., Merkely, B., Drozdz, J., Goncalvesova, E., Hassanein, M., Chioncel, O., Lainscak, M., Seferovic, P. M., Tousoulis, D., Kavoliuniene, A., Fruhwald, F., Fazlibegovic, E., Temizhan, A., Gatzov, P., Erglis, A., Laroche, C., & Mebazaa, A.
- Affiliations
- Unidad de Insuficiencia Cardiaca Avanzada y Trasplante Cardiaco, Complexo Hospitalario Universitario A Coruna, CHUAC , La Coruna ,
- Universitätsmedizin Göttingen (DE)
- European Society of Cardiology (FR)
- University of Warwick (GB)
- University General Hospital Attikon (GR)
- University of Zurich (CH)
- University of Ferrara (IT)
- Azienda Unità Sanitaria Locale Piacenza (IT)
- Cardiology Department, University Hospital 12 de Octubre , Madrid ,
- University of Brescia (IT)
- Heart Failure Unit, S Francisco Xavier Hospital/CHLO NOVA Medical School, Faculdade de Ciências Medicas, Universidade Nova de Lisboa
- Charles University (CZ)
- Bar-Ilan University (IL)
- Inserm (FR)
- Linköping University (SE)
- Semmelweis University, Heart Centre , Budapest ,
- Department of Cardiology, Medical University of Lodz , Lodz ,
- Department of Heart Failure/Transplantation, National Cardiovascular Institute , Bratislava ,
- Alexandria University (EG)
- Carol Davila University of Medicine and Pharmacy (RO)
- Department of Cardiology, General Hospital Celje , Celje ,
- University of Belgrade (RS)
- National and Kapodistrian University of Athens (GR)
- Department of Cardiology, Lithuanian University of Health Sciences , Kaunas ,
- Medical University of Graz (AT)
- Department of Internal Medicine, Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
- Türkiye Yüksek İhtisas Hastanesi (TR)
- Lozenetz Hospital (BG)
- Pauls Stradins Clinical University Hospital , Riga ,
- ORCID
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-06-01
- Volume
- 18
- Issue
- 6
- Pages
- 613-625
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- OpenAlex
- W2465883722
- Cited by
- 798
- References
- 26
- Citations by year
- 2026: 54 · 2025: 88 · 2024: 88 · 2023: 108 · 2022: 97 · 2021: 79 · 2020: 92 · 2019: 61 · 2018: 65 · 2017: 52 · 2016: 13 · 2014: 1
- FWCI
- 52.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, other-oa)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Lithuanian University of Health Sciences (submittedVersion)
- RUC (Universidade Da Coruña) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- ESC.
- Abbott Vascular International (2011-2014)
- Amgen (2012-2015)
- AstraZeneca (2014-2017)
- Bayer (2013-2018)
- Boehringer Ingelheim (2013-2016)
- Boston Scientific (2010-2012)
- The Bristol Myers Squibb
- Pfizer Alliance (2014-2016)
- The Alliance Daiichi Sankyo Europe GmbH
- Eli Lilly and Company (2014-2017)
- Gedeon Richter Plc. (2014-2017)
- Menarini Int. Op. (2010-2012)
- MSD-Merck and Co. (2011-2014)
- Novartis Pharma AG (2014-2017)
- ResMed (2014-2016)
- Sanofi (2010-2011)
- SERVIER (2012-2015)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Keywords
- heart failure, acute heart failure, chronic heart failure, all-cause mortality, one-year outcomes, heart failure hospitalization, regional variation in mortality, clinical epidemiology
- MeSH terms
- Acute Disease, Aged, Aged, 80 and over, Ambulatory Care, Cardiology, Cause of Death, Chronic Disease, Europe, Female, Follow-Up Studies, Heart Failure, Hospitalization, Humans, Male, Middle Aged, Mortality, Prospective Studies, Registries, Societies, Medical, Comorbidity
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