The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial
Abstract
Background With a lifetime risk for major depressive disorder of up to 50%, depression is a common comorbidity in multiple sclerosis but remains widely underdiagnosed and untreated. We investigated the potential of a fully automated, internet-based, cognitive behavioural therapy programme, Deprexis, to reduce depressive symptoms in patients with multiple sclerosis.Methods For this randomised controlled trial, we recruited patients from an outpatient clinic in Hamburg, Germany. Patients aged 18-65 years were eligible for inclusion if they had multiple sclerosis and self-reported depressive symptoms. By use of a computer-generated randomisation sequence, we allocated 90 patients (1:1; no blocking or stratification) to either the intervention group or a waitlist control group for 9 weeks. The primary endpoint was the Beck Depression Inventory (BDI), as assessed by an intention-to-treat analysis. This trial is registered with ClinicalTrials.gov, number NCT01663649.Findings 71 patients completed the trial: 35 patients in the intervention group and 36 patients in the control group. During the intervention, BDI scores decreased in the Deprexis group and increased in the control group, yielding a positive effect of Deprexis relative to the waitlist group (mean group difference -4·02 points [95% CI -7·26 to -0·79], p=0·015, effect size d=0·53). Worsening of depressive symptoms from below to above the clinical cutoff (BDI >13) occurred in three (7%) of 45 patients in the control group and no patients in the Deprexis group. We noted no adverse events with respect to new occurrence of suicidal ideation during the trial.Interpretation Psychological online-intervention programmes could be suitable for patients with multiple sclerosis who are unable to regularly attend therapeutic sessions because of mobility impairments.Funding European Union and the Deutsche Forschungsgemeinschaft.
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“The researchers found that those who completed the 9-week online CBT program reported lower BDI-II scores at post and 6 months follow up compared to those in a waitlist control group.”
From A pilot randomized controlled trial of a tailored cognitive behavioural therapy based intervention for depressive symptoms in those newly diagnosed with multiple sclerosis (2016) · cites this paper as [15]
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Computer-based psychological treatments for depression: A systematic review and meta-analysis
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Mini International Neuropsychiatric Interview
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Depression in multiple sclerosis: a review
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The link between multiple sclerosis and depression
Feinstein, A., Magalhaes, S., Richard, J., Audet, B., & Moore, C. S. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.139 · Cited by 550
Major depression in multiple sclerosis
Patten, S. B., Beck, C. A., Williams, J. V. A., Barbui, C., & Metz, L. M. (2003) · Neurology · doi:10.1212/01.wnl.0000095964.34294.b4 · Cited by 534
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Smith, S. M., Wallace, E., O’Dowd, T., & Fortin, M. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006560.pub3 · Cited by 921
Karyotaki, E., Riper, H., Twisk, J., Hoogendoorn, A., Kleiboer, A., Mira, A., Mackinnon, A., Meyer, B., Botella, C., Littlewood, E., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.0044 · Cited by 691
Self-citationComorbid depression in medical diseases
Gold, S. M., Köhler‐Forsberg, O., Moss-Morris, R. E., Mehnert-Theuerkauf, A., Miranda, J. J., Bullinger, M., Steptoe, A., Whooley, M. A., & Otte, C. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0200-2 · Cited by 583
Self-citationDigital interventions for the treatment of depression: a meta-analytic review
Moshe, I., Terhorst, Y., Philippi, P., Domhardt, M., Cuijpers, P., Cristea, I., Pulkki-Råback, L., Baumeister, H., & Sander, L. B. (2021) · Psychological Bulletin · doi:10.1037/bul0000334 · Cited by 390
Depression in multiple sclerosis
Patten, S. B., Marrie, R. A., & Carta, M. G. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1322555 · Cited by 262
Metadata
- Authors
- Fischer, A., Schröder, J., Vettorazzi, E., Wolf, O. T., Pöttgen, J., Lau, S., Heesen, C., Moritz, S., & Gold, S. M.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Ruhr University Bochum (DE)
- Corresponding author
- Gold, Stefan M
- ORCID
- Venue
- The Lancet Psychiatry
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 2
- Issue
- 3
- Pages
- 217-223
- ISSN
- 2215-0366 (ISSN-L)
- OpenAlex
- W2156610258
- Cited by
- 143
- References
- 39
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 18 · 2023: 17 · 2022: 11 · 2021: 14 · 2020: 17 · 2019: 8 · 2018: 9 · 2017: 12 · 2016: 18 · 2015: 3
- FWCI
- 22.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- CLOK (University of Central Lancashire) (acceptedVersion)
- Funders
- European Union Seventh Framework Program (FP7/2007-2013)
- Heisenberg Fellowship from the Deutsche Forschungsgemeinschaft (DFG, GO1357/4-1 and 5-1)
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- multiple sclerosis, depression, internet-based cognitive behavioral therapy, online intervention, Deprexis, depressive symptoms, waitlist control, Beck Depression Inventory, comorbidities, mobility impairment
- MeSH terms
- Adolescent, Adult, Aged, Depression, Female, Germany, Humans, Male, Middle Aged, Multiple Sclerosis, Psychiatric Status Rating Scales, Therapy, Computer-Assisted, Cognitive Behavioral Therapy, Treatment Outcome, Young Adult
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