The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Prevalence of HIV, hepatitis B, and hepatitis C in people with severe mental illness: a systematic review and meta-analysis
Open accessAbstract
BACKGROUND: Although people with serious mental illnesses have a high risk of contracting blood-borne viral infections, sexual health has largely been neglected by researchers and policy makers involved in mental health. Failure to address this shortcoming could increase morbidity and mortality as a result of undetected and untreated infection. We did a systematic review and meta-analysis to estimate the prevalence of blood-borne viral infection in people with serious mental illness. METHOD: We searched the Cochrane Library, Medline, Embase, PsycInfo, CINAHL, and DARE for studies of the prevalence of HIV, hepatitis B virus, and hepatitis C virus in people with serious mental illness, published between Jan 1, 1980, and Jan 1, 2015. We group prevalence data by region and by virus and estimated pooled prevalence. We did a sensitivity analysis of the effect of study quality on prevalence. FINDINGS: After removal of duplicates, we found 373 abstracts, 91 of which met our eligibility criteria. The prevalences of blood-borne viral infections in people with serious mental illness were higher than in the general population in places with low prevalence of blood-borne viruses, such as the USA and Europe, and on par with the general population in regions with high prevalence of blood-borne viruses (Africa for HIV and southeast Asia for hepatitis B virus and hepatitis C virus). Pooled prevalence of HIV in people with serious mental illness in the USA was 6·0% (95% CI 4·3-8·3). Sensitivity analysis showed that quality scores did not significantly affect prevalence. INTERPRETATION: People with serious mental illness are at risk of blood-borne viral infections. However, because of methodological limitations of the studies the prevalence might be overestimated. Serious mental illness is unlikely to be a sole risk factor and risk of blood-borne viral infection is probably multifactorial and associated with low socioeconomic status, drug and alcohol misuse, ethnic origin, and sex. Health providers should routinely discuss sexual health and risks for blood-borne viruses (including risks related to drug misuse) with people who have serious mental illness, as well as offering testing and treatment for those at risk. FUNDING: Wellcome Trust.
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“In the area of oral health, there is also evidence of decreased access to appropriate care in a range of psychiatric diagnoses including depression, anxiety, substance use disorder and severe mental illness.113,114”
From The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness (2019) · cites this paper as [113]
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Metadata
- Authors
- Hughes, E., Bassi, S., Gilbody, S., Bland, M., & Martin, F.
- Affiliations
- University of Huddersfield (GB)
- University of York (GB)
- Corresponding author
- Hughes, Elizabeth
- Venue
- The Lancet Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 3
- Issue
- 1
- Pages
- 40-48
- ISSN
- 2215-0366 (ISSN-L)
- PMC
- PMC4703902
- OpenAlex
- W2178523807
- Cited by
- 272
- References
- 96
- Citations by year
- 2026: 13 · 2025: 25 · 2024: 25 · 2023: 28 · 2022: 37 · 2021: 44 · 2020: 28 · 2019: 29 · 2018: 16 · 2017: 16 · 2016: 11
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The Lancet Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Huddersfield Repository (University of Huddersfield) (submittedVersion)
- Edinburgh Napier Research Repository (Edinburgh Napier University) (submittedVersion, cc-by)
- Huddersfield Research Portal (University of Huddersfield) (submittedVersion, cc-by)
- Funders
- Wellcome Trust (reference 097829)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Keywords
- HIV, hepatitis B virus, hepatitis C virus, blood-borne viral infections, severe mental illness, prevalence, sexual health, substance abuse, drug abuse, alcohol abuse, socioeconomic status, risk factors
- MeSH terms
- Mental Disorders, Hepatitis B, Hepatitis C, Humans, Severity of Illness Index, HIV Infections, Prevalence
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