Tapering of SSRI treatment to mitigate withdrawal symptoms—authors' reply
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Early interventions, especially psychosocial interventions but also including judicious use of medications such as SSRIs, may have beneficial effects across a range of syndromes.
“Early interventions (especially psychosocial interventions, but also including judicious use of medications such as selective serotonin reuptake inhibitors) may thus have beneficial effects across a range of syndromes. 497”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [497]
Emerging mental ill-health is fluid, made up of a range of clinical presentations which ebb and flow prior to distillation into more stable subsequent phenotypes later in the course of the illness.
“The transdiagnostic perspective 497 recognises that emerging mental ill-health is fluid, made up of a range of clinical presentations which ebb and flow prior to distillation into more stable subsequent phenotypes later in the course of the illness.”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [497]
Cites
Tapering of SSRI treatment to mitigate withdrawal symptoms
Horowitz, M. A., & Taylor, D. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30032-x · Cited by 280 · see citing works
Self-citationMichelson, D., Fava, M., Amsterdam, J., Apter, J., Londborg, P., Tamura, R., & Tepner, R. G. (2000) · British Journal of Psychiatry · doi:10.1192/bjp.176.4.363 · Cited by 181 · see citing works
Tapering of SSRI treatment to mitigate withdrawal symptoms
Ruhe, H. G., Horikx, A., van Avendonk, M. J. P., Groeneweg, B. F., & Woutersen-Koch, H. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30182-8 · Cited by 28 · see citing works
Tapering of SSRI treatment to mitigate withdrawal symptoms
Selvaraj, S., Jauhar, S., Baldwin, D. S., Cowen, P. J., Goodwin, G. M., Hayes, J., Nutt, D., Veronese, M., & Young, A. H. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30183-x · Cited by 7 · see citing works
Tapering of SSRI treatment to mitigate withdrawal symptoms
Kronenberg, G., Desai, D., & Anghelescu, I. G. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30184-1 · Cited by 3 · see citing works
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Time for united action on depression: a Lancet–World Psychiatric Association Commission
Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., Furukawa, T. A., Kessler, R. C., Kohrt, B. A., Maj, M., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02141-3 · Cited by 1,104 · see citing works
Adverse Effects of Antidepressant Medications and their Management in Children and Adolescents
Strawn, J. R., Mills, J. A., Poweleit, E. A., Ramsey, L. B., & Croarkin, P. E. (2023) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2767 · Cited by 200 · see citing works
Fineberg, N. A., Hollander, E., Pallanti, S., Walitza, S., Grünblatt, E., Dell’Osso, B. M., Albert, U., Geller, D. A., Brakoulias, V., Janardhan Reddy, Y. C., et al. (2020) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000314 · Cited by 161 · see citing works
Estimating Risk of Antidepressant Withdrawal from a Review of Published Data
Horowitz, M. A., Framer, A., Hengartner, M. P., Sørensen, A., & Taylor, D. (2023) · CNS Drugs · doi:10.1007/s40263-022-00960-y · Cited by 76 · see citing works
Self-citationBlackman, G., Oloyede, E., Horowitz, M. A., Harland, R., Taylor, D. M., MacCabe, J. H., & McGuire, P. K. (2021) · Schizophrenia Bulletin · doi:10.1093/schbul/sbab103 · Cited by 49 · see citing works
Self-citationGarcia, I., & O’Neil, J. (2020) · The Journal for Nurse Practitioners · doi:10.1016/j.nurpra.2020.08.021 · Cited by 50 · see citing works
Price, C. M., Feduccia, A. A., & DeBonis, K. (2022) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001595 · Cited by 17 · see citing works
Trazodone once-a-day: A formula for addressing challenges in antidepressant safety and tolerability
Goldberg, J. F., Steinman, M. Q., & Stahl, S. M. (2023) · Neuroscience Applied · doi:10.1016/j.nsa.2023.101127 · Cited by 6 · see citing works
SOP Absetzen von Antidepressiva
Bschor, T., & Kleemann, A. M. (2022) · PSYCH up2date · doi:10.1055/a-1673-8792 · Cited by 2 · see citing works
Zhang, R. H. (2026) · Nutritional Psychiatry · doi:10.1016/j.nupsyc.2026.100024 · Cited by 1 · see citing works
Carreno, F. R., & Frazer, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00044-x
Behandlung bei psychischer und körperlicher Komorbidität
Voderholzer, U., Rubart, A., Kathmann, N., Staniloiu, A., Kordon, A., & Zurowski, B. (2024) · Springer eBooks · doi:10.1007/978-3-662-67878-7_11
Introduction to Deprescribing Psychiatric Medications
(2024) · Wiley eBooks · doi:10.1002/9781394291052.mdg001
Safe Deprescribing of Antidepressants
(2024) · Wiley eBooks · doi:10.1002/9781394291052.mdg002
Kubenz, K. (2026) · Springer eBooks · doi:10.1007/978-3-662-72335-7_24
- Authors
- Horowitz, M. A., & Taylor, D.
- Affiliations
- Prince of Wales Hospital (AU)
- King's College London (GB)
- Corresponding author
- Horowitz, Mark Abie
- Venue
- The Lancet Psychiatry
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 6
- Issue
- 7
- Pages
- 562-563
- ISSN
- 2215-0366 (ISSN-L)
- OpenAlex
- W2951382751
- Cited by
- 15
- References
- 5
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- antidepressant tapering, plasma drug concentration, selective serotonin reuptake inhibitors, drug interruption, pharmacokinetics, adverse drug reactions, depression treatment
- MeSH terms
- Humans, Substance Withdrawal Syndrome
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