Cited by 85Pharmacological Effects of Medicinal PlantsNatural Antidiabetic Agents StudiesPhytochemicals and Medicinal Plants

Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats

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Ramesh, B, Karuna, R, Sreenivasa, Reddy S, Haritha, K, Sai, Mangala D, Sasis, Bhusana Rao B, Saralakumari, D·2012·Asian Pacific Journal of Tropical Biomedicine

Abstract

OBJECTIVE: To study the antioxidant efficacy of Commiphora mukul (C. mukul) gum resin ethanolic extract in streptozotocin (STZ) induced diabetic rats. METHODS: THE MALE WISTAR ALBINO RATS WERE RANDOMLY DIVIDED INTO FOUR GROUPS OF EIGHT ANIMALS EACH: Control group (C), CM-treated control group (C+CMEE), Diabetic control group (D), CM- treated diabetic group (D+CMEE). Diabetes was induced by intraperitoneal injection of STZ (55 mg/kg/ bwt). After being confirmed the diabetic rats were treated with C. mukul gum resin ethanolic extract (CMEE) for 60 days. The biochemical estimations like antioxidant, oxidative stress marker enzymes and hepatic marker enzymes of tissues were performed. RESULTS: The diabetic rats showed increased level of enzymatic activities aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) in liver and kidney and oxidative markers like lipid peroxidation (LPO) and protein oxidation (PO) in pancreas and heart. Antioxidant enzyme activities were significantly decreased in the pancreas and heart compared to control group. Administration of CMEE (200 mg/kg bw) to diabetic rats for 60 days significantly reversed the above parameters towards normalcy. CONCLUSIONS: In conclusion, our data indicate the preventive role of C. mukul against STZ-induced diabetic oxidative stress; hence this plant could be used as an adjuvant therapy for the prevention and/or management of diabetes and aggravated antioxidant status.

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Authors
Ramesh, B., Karuna, R., Sreenivasa, R. S., Haritha, K., Sai, M. D., Sasis, B. R. B., & Saralakumari, D.
Affiliations
  • Sri Venkateswara University (IN)
  • Sri Krishnadevaraya University (IN)
  • Sri Sathya Sai Institute of Higher Medical Sciences (IN)
Corresponding author
Saralakumari, D
Venue
Asian Pacific Journal of Tropical Biomedicine
Publisher
Medknow
Published
2012-11
Volume
2
Issue
11
Pages
895-900
ISSN
2221-1691 (ISSN-L)
OpenAlex
W2126974297
Cited by
85
References
46
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 11 · 2022: 6 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 11 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 8 · 2013: 3 · 2012: 2
FWCI
3.77
Type
journal article
Language
en
Open access
Locations
  • Asian Pacific Journal of Tropical Biomedicine (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Pharmacological Effects of Medicinal Plants
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Keywords
Commiphora mukul, gum resin, streptozotocin-induced diabetes, oxidative stress, lipid peroxidation, antioxidant enzymes, aspartate aminotransferase, alanine aminotransferase, protein oxidation, pancreas, heart, ethanolic plant extract
MeSH terms
Alanine Transaminase, Animals, Antioxidants, Aspartate Aminotransferases, Diabetes Mellitus, Experimental, Heart, Liver, Male, Myocardium, Oxidoreductases, Pancreas, Plant Extracts, Lipid Peroxidation, Rats, Wistar, Commiphora, Rats

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