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Cited by 123

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies

Dear, James W, Clarke, Joanna I, Francis, Ben, Allen, Lowri, Wraight, Jonathan, Shen, Jasmine, Dargan, Paul I, Wood, David, Cooper, Jamie, Thomas, Simon H L, Jorgensen, Andrea L, Pirmohamed, Munir, Park, B Kevin, Antoine, Daniel J·2018·The Lancet Gastroenterology & Hepatology
DOI 10.1016/s2468-1253(17)30266-2PMC PMC5777094
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  • MicroRNA-122 is a hepatocyte-specific miRNA that is elevated in the plasma of patients with APAP overdose before the ALT level is elevated and is considered able to predict the onset of liver injury at an early time point.

    “MicroRNA-122 is a hepatocyte-specific miRNA that is elevated in the plasma of patients with APAP overdose before the ALT level is elevated and is considered able to predict the onset of liver injury at an early time point [174].”

    From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [174]

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Citations

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Research works printed but not linked: 34

  1. Larson, 2005, Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study, Hepatology, 42, 1364, 10.1002/hep.20948 · DOI
  2. Bernal, 2010, Acute liver failure, Lancet, 376, 190, 10.1016/S0140-6736(10)60274-7 · DOI
  3. Hinson, 2010, Mechanisms of acetaminophen-induced liver necrosis, Handb Exp Pharmacol, 369, 10.1007/978-3-642-00663-0_12 · DOI · Paper page
  4. Antoine, 2012, Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity, J Hepatol, 56, 1070, 10.1016/j.jhep.2011.12.019 · DOI
  5. Smilkstein, 1988, Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985), N Engl J Med, 319, 1557, 10.1056/NEJM198812153192401 · DOI · Paper page
  6. Dear, 2014, Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges, Expert Rev Clin Pharmacol, 7, 181, 10.1586/17512433.2014.880650 · DOI · Paper page
  7. Clarke, 2016, Recent advances in biomarkers and therapeutic interventions for hepatic drug safety—false dawn or new horizon?, Expert Opin Drug Saf, 15, 625, 10.1517/14740338.2016.1160057 · DOI · Paper page
  8. Antoine, 2016, How to treat paracetamol overdose and when to do it, Expert Rev Clin Pharmacol, 9, 633, 10.1586/17512433.2016.1154786 · DOI
  9. Craig, 2012, Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity, Br J Clin Pharmacol, 73, 285, 10.1111/j.1365-2125.2011.04067.x · DOI
  10. Park, 2015, Paracetamol (acetaminophen) poisoning, BMJ Clin Evid, 2015
  11. Huebener, 2015, The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis, J Clin Invest, 125, 539, 10.1172/JCI76887 · DOI
  12. Stutchfield, 2015, CSF1 restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure, Gastroenterology, 149, 1896, 10.1053/j.gastro.2015.08.053 · DOI
  13. Antoine, 2013, Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital, Hepatology, 58, 777, 10.1002/hep.26294 · DOI
  14. Vliegenthart, 2015, Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury, Sci Rep, 5, 15501, 10.1038/srep15501 · DOI
  15. McGill, 2012, The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation, J Clin Invest, 2012, 1574, 10.1172/JCI59755 · DOI
  16. Bossuyt, 2003, The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration, Ann Intern Med, 138, W1, 10.7326/0003-4819-138-1-200301070-00012-w1 · DOI · Paper page
  17. Bossuyt, 2003, The STARD initiative, Lancet, 361, 71, 10.1016/S0140-6736(03)12122-8 · DOI
  18. Lewis, 2012, Authors' reply, Hepatology, 55, 1642, 10.1002/hep.25565 · DOI
  19. Al-Hourani, 2013, The predictive value of hospital admission serum alanine transaminase activity in patients treated for paracetamol overdose, QJM, 106, 541, 10.1093/qjmed/hct062 · DOI
  20. Pickering, 2012, New metrics for assessing diagnostic potential of candidate biomarkers, Clin J Am Soc Nephrol, 7, 1355, 10.2215/CJN.09590911 · DOI
  21. McCrae, 2016, Ethanol consumption produces a small increase in circulating miR-122 in healthy individuals, Clin Toxicol, 54, 53, 10.3109/15563650.2015.1112015 · DOI
  22. Holman, 2016, Subtoxic alterations in hepatocyte-derived exosomes: an early step in drug-induced liver injury?, Toxicol Sci, 151, 365, 10.1093/toxsci/kfw047 · DOI
  23. Zhang, 2010, Plasma microRNA-122 as a biomarker for viral-, alcohol-, and chemical-related hepatic diseases, Clin Chem, 56, 1830, 10.1373/clinchem.2010.147850 · DOI · Paper page
  24. Bateman, 2014, Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial, Lancet, 383, 697, 10.1016/S0140-6736(13)62062-0 · DOI
  25. Aithal, 2011, Case definition and phenotype standardization in drug-induced liver injury, Clin Pharmacol Ther, 89, 806, 10.1038/clpt.2011.58 · DOI
  26. Green, 2010, When do the aminotransferases rise after acute acetaminophen overdose?, Clin Toxicol, 48, 787, 10.3109/15563650.2010.523828 · DOI
  27. Schmidt, 2007, MELD score as a predictor of liver failure and death in patients with acetaminophen-induced liver injury, Hepatology, 45, 789, 10.1002/hep.21503 · DOI
  28. Wang, 1999, HMG-1 as a late mediator of endotoxin lethality in mice, Science, 285, 248, 10.1126/science.285.5425.248 · DOI
  29. Yang, 2013, The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis, J Leukoc Biol, 93, 865, 10.1189/jlb.1212662 · DOI · Paper page
  30. Lundbäck, 2016, A novel HMGB1 neutralizing chimeric antibody attenuates DILI and post-injury inflammation, Hepatology, 64, 1699, 10.1002/hep.28736 · DOI
  31. Yang, 2015, MD-2 is required for disulfide HMGB1-dependent TLR4 signaling, J Exp Med, 212, 5, 10.1084/jem.20141318 · DOI
  32. Rissin, 2017, Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: detection of drug-induced liver injury, PLoS One, 12, e0179669, 10.1371/journal.pone.0179669 · DOI
  33. Cairney, 2016, Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine, Clin Toxicol (Phila), 54, 405, 10.3109/15563650.2016.1159309 · DOI
  34. Dear, 2014, Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis, Br J Clin Pharmacol, 77, 904, 10.1111/bcp.12214 · DOI

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Metadata

Authors
Dear, J. W., Clarke, J. I., Francis, B., Allen, L., Wraight, J., Shen, J., Dargan, P. I., Wood, D., Cooper, J., Thomas, S. H. L., Jorgensen, A. L., Pirmohamed, M., Park, B. K., & Antoine, D. J.
Venue
The Lancet Gastroenterology & Hepatology
Publisher
Elsevier BV
Published
2018-02
Volume
3
Issue
2
Pages
104-113
ISSN
2468-1253
DOI
10.1016/s2468-1253(17)30266-2
PMC
PMC5777094
Cited by
123
References
4
Language
en
Licence

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