Danger-Associated Molecular Patterns (DAMPs): Molecular Triggers for Sterile Inflammation in the Liver
Open accessAbstract
Inflammatory liver diseases in the absence of pathogens such as intoxication by xenobiotics, cholestatic liver injury, hepatic ischemia-reperfusion injury (I/R), non-alcoholic steatohepatitis (NASH), or alcoholic liver disease (ALD) remain threatening conditions demanding specific therapeutic options. Caused by various different noxae, all these conditions have been recognized to be triggered by danger- or death-associated molecular patterns (DAMPs), discompartmentalized self-structures released by dying cells. These endogenous, ectopic molecules comprise proteins, nucleic acids, adenosine triphosphate (ATP), or mitochondrial compounds, among others. This review resumes the respective modes of their release—passively by necrotic hepatocytes or actively by viable or apoptotic parenchymal cells—and their particular roles in sterile liver pathology. It addresses their sensors and the initial inflammatory responses they provoke. It further addresses a resulting second wave of parenchymal death that might be of different mode, boosting the release of additional, second-line DAMPs. Thus, triggering a more complex and pronounced response. Initial and secondary inflammatory responses comprise the activation of Kupffer cells (KCs), the attraction and activation of monocytes and neutrophil granulocytes, and the induction of type I interferons (IFNs) and their effectors. A thorough understanding of pathophysiology is a prerequisite for identifying rational therapeutic targets.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
DAMPs like HMGB1 bind TLR4/MyD88 in Kupffer cells, leading to NF-κB and generation of pro-inflammatory and pro-fibrotic mediators TGF-β1 and IL-1β.
“Damage-associated molecular patterns (DAMPs), like high-mobility group box 1 (HMGB1) or fragmented DNA, are released from hepatocytes. Endogenous danger stimuli bind to Toll-like receptor 4(TRL4) with the MyD88 adaptor protein in Kupffer cells. TLR4/MyD88, prompts the protein NF-κB to lead to the generation of pro-inflammatory and pro-fibrotic mediators associated with the disease—such as TGF-β1”
From From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy (2025) · cites this paper as [33]
Section 2 (page not supplied) says HMGB1 interacts with TLR4, and section 5.3 describes hepatocyte HMGB1 release and a Kupffer-cell response to TLR4 activation. The copy does not establish the claimed MyD88–NF-κB pathway or its production of TGF-β1 and IL-1β; section 5 instead links IL-1β release to mitochondrial DNA and NLRP3 inflammasomes. (LLM, conf=0.86)
Experimental — accuracy not yet measuredTNF-α and IL-1β activate NF-κB in HSCs, inducing pro-fibrotic gene expression and inhibiting HSC apoptosis.
“Pro-inflammatory cytokines TNF-α and IL-1β (secreted by M1 macrophages) activate NF-κB within HSCs, inducing pro-fibrotic gene expression and inhibiting HSC apoptosis.”
From From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy (2025) · cites this paper as [33]
Section 5 (Mitochondrial DAMPs; page unavailable) describes TNF-α release by macrophages, and Section 4 (ATP; page unavailable) describes IL-1β activation and secretion. Neither passage addresses whether these cytokines activate NF-κB in hepatic stellate cells, induce pro-fibrotic genes, or inhibit stellate-cell apoptosis. Searches for stellate cells, NF-κB, and the cytokines found no passage establishing that mechanism. (LLM, conf=0.75)
Experimental — accuracy not yet measuredTGF-β1 binds TβRII on HSCs, phosphorylates Smad2/3; the complex translocates to the nucleus, activating α-SMA, collagen I/III, and TIMP-1 while suppressing MMPs.
“TGF-β1 (released by Kupffer cells, platelets, and injured hepatocytes) binds to TβRII receptors on HSCs, leading to phosphorylation of Smad2/3. The phospho-Smad2/3-Smad4 complex translocates to the nucleus, activating genes encoding α-smooth muscle actin (α-SMA), collagen I and III, and tissue inhibitor of metalloproteinase-1 (TIMP-1) while suppressing matrix metalloproteinases (MMPs).”
From From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy (2025) · cites this paper as [33]
The supplied passages from section 2 (HMGB1) and section 5 (Mitochondrial DAMPs) discuss danger signals and inflammatory signaling, not TGF-β1 signaling in hepatic stellate cells. Searches for Smad, TβRII, α-SMA, collagen, TIMP-1, and MMPs found no passage in our copy addressing the claimed pathway. (LLM, conf=0.76)
Experimental — accuracy not yet measuredChemokines CCL2 and CXCL8 recruit monocytes, perpetuating the inflammatory response and fibrosis.
“Chemokines such as CCL2 and CXCL8 recruit monocytes, perpetuating the inflammatory response and fibrosis [33, 34].”
From From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy (2025) · cites this paper as [33]
Section 2.2 discusses chemokine induction and likely neutrophil recruitment, but does not link CCL2 or CXCL8 to monocyte recruitment or fibrosis. Searches for CCL2, CXCL8, and monocyte recruitment with fibrosis found no passage in our copy establishing the claimed pathway. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Antoine, D. J., Jenkins, R. E., Dear, J. W., Williams, D. P., McGill, M. R., Sharpe, M. R., Craig, D. G. N., Simpson, K. J., Jaeschke, H., & Park, B. K. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.12.019 · Cited by 307 · see citing works
RetractedYounossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016) · Hepatology · doi:10.1002/hep.28431 · Cited by 10,781 · see citing works
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,848 · see citing works
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221 · see citing works
The Danger Model: A Renewed Sense of Self
Matzinger, P. (2002) · Science · doi:10.1126/science.1071059 · Cited by 4,205 · see citing works
Interferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067 · see citing works
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
Lotze, M. T., & Tracey, K. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1594 · Cited by 2,490 · see citing works
Nonalcoholic Fatty Liver Disease
Rinella, M. E. (2015) · JAMA · doi:10.1001/jama.2015.5370 · Cited by 2,289 · see citing works
Ostapowicz, G., Fontana, R. J., Schiødt, F. V., Larson, A., Davern, T. J., Han, S. H. B., McCashland, T. M., Shakil, A. O., Hay, J. E., Hynan, L., et al. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-12-200212170-00007 · Cited by 2,227 · see citing works
Gray, M. W., Burger, G., & Lang, B. F. (1999) · Science · doi:10.1126/science.283.5407.1476 · Cited by 1,710 · see citing works
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Elliott, M. R., Chekeni, F. B., Trampont, P. C., Lazarowski, E. R., Kadl, A., Walk, S. F., Park, D., Woodson, R. I., Ostankovich, M., Sharma, P., et al. (2009) · Nature · doi:10.1038/nature08296 · Cited by 1,654 · see citing works
The JAK-STAT Pathway at Twenty
Stark, G. R., & Darnell, J. E., Jr. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.013 · Cited by 1,523 · see citing works
Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372 · see citing works
A lipidomic analysis of nonalcoholic fatty liver disease
Puri, P., Baillie, R. A., Wiest, M. M., Mirshahi, F., Choudhury, J., Cheung, O., Sargeant, C., Contos, M. J., & Sanyal, A. J. (2007) · Hepatology · doi:10.1002/hep.21763 · Cited by 1,338 · see citing works
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
Bonaldi, T., Talamo, F., Scaffidi, P., Ferrera, D., Porto, A., Bachi, A., Rubartelli, A., Agresti, A., & Bianchi, M. E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg516 · Cited by 1,252 · see citing works
Mofrad, P., Contos, M., Haque, M., Sargeant, C. C., Fisher, R., Luketic, V., Sterling, R., Shiffman, M., Stravitz, R., & Sanyal, A. (2003) · Hepatology · doi:10.1053/jhep.2003.50229 · Cited by 1,221 · see citing works
Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation
McDonald, B., Pittman, K., Menezes, G. B., Hirota, S. A., Slaba, I., Waterhouse, C. C. M., Beck, P. L., Muruve, D. A., & Kubes, P. (2010) · Science · doi:10.1126/science.1195491 · Cited by 1,210 · see citing works
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., Armstrong, A. J., Penuela, S., Laird, D. W., Salvesen, G. S., et al. (2010) · Nature · doi:10.1038/nature09413 · Cited by 1,120 · see citing works
Mitochondrial DNA in innate immune responses and inflammatory pathology
West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.21 · Cited by 1,115 · see citing works
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
Tsung, A., Sahai, R., Tanaka, H., Nakao, A., Fink, M. P., Lotze, M. T., Yang, H., Li, J., Tracey, K. J., Geller, D. A., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042614 · Cited by 1,113 · see citing works
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., & Gores, G. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00907-7 · Cited by 1,085 · see citing works
Neuschwander‐Tetri, B. A. (2010) · Hepatology · doi:10.1002/hep.23719 · Cited by 1,077 · see citing works
Koliaki, C., Szendroedi, J., Kaul, K., Jelenik, T., Nowotny, P., Jankowiak, F., Herder, C., Carstensen, M., Krausch, M., Knoefel, W. T., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.004 · Cited by 1,032 · see citing works
Mechanisms of Acetaminophen-Induced Liver Necrosis
Hinson, J., Roberts, D. W., & James, L. P. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-00663-0_12 · Cited by 993 · see citing works
Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
White, M. J., McArthur, K., Metcalf, D., Lane, R. M., Cambier, J. C., Herold, M. J., van Delft, M. F., Bedoui, S., Lessene, G., Ritchie, M. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.036 · Cited by 983 · see citing works
Gardella, S., Andrei, C., Ferrera, D., Lotti, L. V., Torrisi, M. R., Bianchi, M. E., & Rubartelli, A. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf198 · Cited by 926 · see citing works
Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
Rongvaux, A., Jackson, R., Harman, C. C. D., Li, T., West, A. P., de Zoete, M. R., Wu, Y., Yordy, B., Lakhani, S. A., Kuan, C.-Y., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.037 · Cited by 847 · see citing works
Novel role of PKR in inflammasome activation and HMGB1 release
Lü, B., Nakamura, T., Inouye, K., Li, J., Tang, Y., Lundbäck, P., Valdés‐Ferrer, S. I., Olofsson, P. S., Kalb, T. H., Roth, J., et al. (2012) · Nature · doi:10.1038/nature11290 · Cited by 772 · see citing works
McGill, M. R., Sharpe, M. R., Williams, C. D., Taha, M., Curry, S. C., & Jaeschke, H. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59755 · Cited by 764 · see citing works
Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance
Luedde, T., Kaplowitz, N., & Schwabe, R. F. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.018 · Cited by 760 · see citing works
Gut–Liver Axis in Alcoholic Liver Disease
Szabo, G. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.10.042 · Cited by 754 · see citing works
Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release
Venereau, E., Casalgrandi, M., Schiraldi, M., Antoine, D. J., Cattaneo, A., De Marchis, F., Liu, J., Antonelli, A., Preti, A., Raeli, L., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120189 · Cited by 720 · cited 2× · see citing works
“Full oxidation of HMGB1 abrogates its chemokine and cytokine activities and associates with resolution of inflammation [23,25].”
BackgroundParlesak, A., Schäfer, C., Schütz, T., Bode, J. C., & Bode, C. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80242-1 · Cited by 647 · see citing works
Csak, T., Ganz, M., Pespisa, J., Kodys, K., Dolganiuc, A., & Szabo, G. (2011) · Hepatology · doi:10.1002/hep.24341 · Cited by 645 · see citing works
Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease
Begriche, K., Massart, J., Robin, M.-A., Bonnet, F., & Fromenty, B. (2013) · Hepatology · doi:10.1002/hep.26226 · Cited by 628 · see citing works
Tsung, A., Klune, J. R., Zhang, X., Jeyabalan, G., Cao, Z., Peng, X., Stolz, D. B., Geller, D. A., Rosengart, M. R., & Billiar, T. R. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070247 · Cited by 617 · see citing works
Hyeon, C. K., Chung, M. N., Jee, S. H., Kwang, H. H., Oh, D. K., & Suh, I. (2004) · BMJ · doi:10.1136/bmj.38050.593634.63 · Cited by 598 · see citing works
The Role of Cholesterol in the Pathogenesis of NASH
Ioannou, G. N. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.11.008 · Cited by 498 · see citing works
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9
Garcia-Martinez, I., Santoro, N., Chen, Y., Hoque, R., Ouyang, X., Caprio, S., Shlomchik, M. J., Coffman, R. L., Candia, A., & Mehal, W. Z. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83885 · Cited by 498 · see citing works
NLRP3 inflammasome activation is required for fibrosis development in NAFLD
Wree, A., McGeough, M. D., Peña, C. A., Schlattjan, M., Li, H., Inzaugarat, M. E., Messer, K., Canbay, A., Hoffman, H. M., & Feldstein, A. E. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1170-1 · Cited by 486 · see citing works
Intermediate Filament Proteins and Their Associated Diseases
Omary, M. B., Coulombe, P. A., & McLean, W. H. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmra040319 · Cited by 486 · see citing works
Endotoxemia and gut barrier dysfunction in alcoholic liver disease†
Rao, R. (2009) · Hepatology · doi:10.1002/hep.23009 · Cited by 476 · see citing works
Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia
Lamkanfi, M., Sarkar, A., Walle, L. V., Vitari, A. C., Amer, A. O., Wewers, M. D., Tracey, K. J., Kanneganti, T., & Dixit, V. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000803 · Cited by 468 · see citing works
Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
Karmakar, M., Katsnelson, M. A., Dubyak, G. R., & Pearlman, E. (2016) · Nature Communications · doi:10.1038/ncomms10555 · Cited by 450 · see citing works
Petrasek, J., Iracheta‐Vellve, A., Csák, T., Satishchandran, A., Kodys, K., Kurt‐Jones, E. A., Fitzgerald, K. A., & Szabó, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308331110 · Cited by 449 · see citing works
Activation of Autophagy Protects Against Acetaminophen–Induced Hepatotoxicity
Ni, H., Bockus, A. B., Boggess, N., Jaeschke, H., & Ding, W. (2011) · Hepatology · doi:10.1002/hep.24690 · Cited by 429 · see citing works
Antoine, D. J., Dear, J. W., Lewis, P. J. S., Platt, V., Coyle, J., Masson, M., Thanacoody, R. H. K., Gray, A. J., Webb, D. J., Moggs, J. G., et al. (2013) · Hepatology · doi:10.1002/hep.26294 · Cited by 427 · see citing works
Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases
Grazioli, S., & Pugin, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00832 · Cited by 418 · see citing works
Bianchi, M. E. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008585 · Cited by 415 · see citing works
Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure
Woolbright, B. L., & Jaeschke, H. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.11.017 · Cited by 393 · see citing works
MD-2 is required for disulfide HMGB1–dependent TLR4 signaling
Yang, H., Wang, H., Ju, Z., Ragab, A. A. Y., Lundbäck, P., Long, W., Valdés‐Ferrer, S. I., He, M., Pribis, J. P., Li, J., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141318 · Cited by 379 · see citing works
Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH
Caballero, F., Fernández, A., De Lacy, A. M., Fernández-Checa, J. C., Caballería, J., & García-Ruiz, C. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.12.016 · Cited by 368 · see citing works
High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
Yang, H., Wang, H., Chavan, S. S., & Andersson, U. (2015) · Molecular Medicine · doi:10.2119/molmed.2015.00087 · Cited by 360 · see citing works
The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis
Huebener, P., Pradère, J., Hernandez, C., Gwak, G., Caviglia, J. M., Mu, X., Loike, J. D., Jenkins, R. E., Antoine, D. J., & Schwabe, R. F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76887 · Cited by 353 · see citing works
Ruhl, C. E., & Everhart, J. E. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.052 · Cited by 350 · see citing works
Marques, P. E., Amaral, S. S., Pires, D. A., Nogueira, L. L., Soriani, F. M., Lima, B. H. F., Lopes, G. A. O., Russo, R. C., Ávila, T. V., Melgaço, J. G., et al. (2012) · Hepatology · doi:10.1002/hep.25801 · Cited by 332 · see citing works
High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells
Andersson, U., Yang, H., & Harris, H. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.02.011 · Cited by 309 · see citing works
The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis
Huebener, P., Pradère, J., Hernandez, C., Gwak, G., Caviglia, J. M., Mu, X., Loike, J. D., Jenkins, R. E., Antoine, D. J., & Schwabe, R. F. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126975 · Cited by 301 · see citing works
The ascending pathophysiology of cholestatic liver disease
Jansen, P. L. M., Ghallab, A., Vartak, N., Reif, R., Schaap, F. G., Hampe, J., & Hengstler, J. G. (2017) · Hepatology · doi:10.1002/hep.28965 · Cited by 301 · see citing works
Regulation of immunity and oncogenesis by the IRF transcription factor family
Savitsky, D., Tamura, T., Yanai, H., & Taniguchi, T. (2010) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-009-0804-6 · Cited by 298 · see citing works
Mechanisms of bile acid mediated inflammation in the liver
Li, M., Cai, S., & Boyer, J. L. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.06.001 · Cited by 268 · see citing works
Toward unraveling the complexity of simple epithelial keratins in human disease
Omary, M. B., Ku, N., Strnad, P., & Hanada, S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37762 · Cited by 267 · see citing works
Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
Alkhouri, N., Carter-Kent, C. A., & Feldstein, A. E. (2011) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.11.6 · Cited by 255 · see citing works
PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils
Heit, B., Robbins, S. M., Downey, C. M., Guan, Z., Colarusso, P., Miller, B. J., Jirik, F. R., & Kubes, P. (2008) · Nature Immunology · doi:10.1038/ni.1623 · Cited by 254 · see citing works
Evankovich, J. W., Cho, S. W., Zhang, R., Cardinal, J. S., Dhupar, R., Zhang, L., Klune, J. R., Zlotnicki, J. P., Billiar, T. R., & Tsung, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.128348 · Cited by 242 · see citing works
Li, L., Chen, L., Hu, L., Liu, Y., Sun, H., Tang, J. P., Hou, Y.-J., Chang, Y., Tu, Q., Feng, G., et al. (2011) · Hepatology · doi:10.1002/hep.24552 · Cited by 236 · see citing works
Biomarkers of liver cell death
Eguchi, A., Wree, A., & Feldstein, A. E. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.026 · Cited by 220 · see citing works
Serum aminotransferase activity and mortality risk in a United States community
Lee, T. H., Kim, W. R., Benson, J. T., Therneau, T. M., & Melton, J. L. (2008) · Hepatology · doi:10.1002/hep.22090 · Cited by 208 · see citing works
Gan, L. T., Rooyen, D. M. V., Koina, M. E., McCuskey, R. S., Teoh, N., & Farrell, G. C. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.07.024 · Cited by 199 · see citing works
Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis
Woolbright, B. L., Dorko, K., Antoine, D. J., Clarke, J. I., Gholami, P., Li, F., Kumer, S. C., Schmitt, T. M., Forster, J., Fan, F., et al. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.01.015 · Cited by 190 · see citing works
Liver autophagy: much more than just taking out the trash
Schneider, J. L., & Cuervo, A. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.211 · Cited by 189 · see citing works
McGill, M. R., Staggs, V. S., Sharpe, M. R., Lee, W. M., & Jaeschke, H. (2014) · Hepatology · doi:10.1002/hep.27265 · Cited by 182 · see citing works
Kunutsor, S. K., Apekey, T. A., Seddoh, D., & Walley, J. D. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyt192 · Cited by 174 · see citing works
New Aspects of Lipotoxicity in Nonalcoholic Steatohepatitis
Méndez‐Sánchez, N., Cruz-Ramón, V., Ramírez-Pérez, O., Hwang, J. P., Barranco-Fragoso, B., & Córdova‐Gallardo, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072034 · Cited by 174 · see citing works
Haselow, K., Bode, J. G., Wammers, M., Ehlting, C., Keitel, V., Kleinebrecht, L., Schupp, A.-K., Häussinger, D., & Graf, D. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0812396 · Cited by 164 · see citing works
MacFarlane, M., Merrison, W., Dinsdale, D. D., & Cohen, G. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.6.1239 · Cited by 157 · see citing works
High mobility group box 1 orchestrates tissue regeneration via CXCR4
Tirone, M., Tran, N. L., Ceriotti, C., Gorzanelli, A., Canepari, M., Bottinelli, R., Raucci, A., Maggio, S. D., Santiago, C. A., Mellado, M., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20160217 · Cited by 153 · see citing works
Positive feedback regulation of type I interferon by the interferon‐stimulated gene STING
Ma, F., Li, B., Yu, Y., Iyer, S. S., Sun, M., & Cheng, G. (2015) · EMBO Reports · doi:10.15252/embr.201439366 · Cited by 146 · see citing works
Huang, H., Nace, G., McDonald, K.-A., Tai, S., Klune, J. R., Rosborough, B. R., Ding, Q., Loughran, P., Zhu, X., Beer–Stolz, D., et al. (2013) · Hepatology · doi:10.1002/hep.26976 · Cited by 146 · see citing works
TLRs/NLRs: Shaping the landscape of host immunity
Dolasia, K., Bisht, M. K., Pradhan, G., Udgata, A., & Mukhopadhyay, S. (2017) · International Reviews of Immunology · doi:10.1080/08830185.2017.1397656 · Cited by 146 · see citing works
Extracellular nucleosides and nucleotides as immunomodulators
Kepp, O., Loos, F., Liu, P., & Kroemer, G. (2017) · Immunological Reviews · doi:10.1111/imr.12571 · Cited by 144 · see citing works
Kano, A., Haruyama, T., Akaike, T., & Watanabe, Y. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0276 · Cited by 135 · see citing works
Dear, J. W., Clarke, J. I., Francis, B., Allen, L. A., Wraight, J., Shen, J., Dargan, P. I., Wood, D. M., Cooper, J. G., Thomas, S. H. L., et al. (2017) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(17)30266-2 · Cited by 131 · see citing works
Keratins: Biomarkers and modulators of apoptotic and necrotic cell death in the liver
Ku, N., Strnad, P., Bantel, H., & Omary, M. B. (2016) · Hepatology · doi:10.1002/hep.28493 · Cited by 130 · see citing works
Pathogenesis of Kupffer Cells in Cholestatic Liver Injury
Sato, K., Hall, C. M., Glaser, S. S., Francis, H., Meng, F., & Alpini, G. D. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.06.003 · Cited by 120 · see citing works
A prospective study of the utility of plasma biomarkers to diagnose alcoholic hepatitis
Bissonnette, J., Altamirano, J., Devue, C., Roux, O., Payancé, A., Lebrec, D., Bédossa, P., Valla, D. C., Durand, F., Ait‐Oufella, H., et al. (2017) · Hepatology · doi:10.1002/hep.29080 · Cited by 118 · see citing works
cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING
Lei, Z., Deng, M., Yi, Z., Sun, Q., Shapiro, R. A., Xu, H., Li, T., Loughran, P., Griepentrog, J. E., Huang, H., et al. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00326.2017 · Cited by 117 · see citing works
NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury
Xiahou, Z., Wang, X., Shen, J., Zhu, X., Feng, X., Hu, R., Guo, D., Li, H., Tian, Y., Liu, Y., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00930-9 · Cited by 115 · see citing works
A Janus Tale of Two Active High Mobility Group Box 1 (HMGB1) Redox States
Tang, D., Billiar, T. R., & Lotze, M. T. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00314 · Cited by 112 · see citing works
Ghallab, A., Hofmann, U., Sezgin, S., Vartak, N., Hassan, R., Zaza, A., Godoy, P., Schneider, K. M., Guenther, G., Ahmed, Y. A., et al. (2019) · Hepatology · doi:10.1002/hep.30213 · Cited by 101 · see citing works
Penzo, M., Molteni, R., Suda, T., Samaniego, S., Raucci, A., Habiel, D. M., Miller, F. W., Jiang, H.-P., Li, J., Pardi, R., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903131 · Cited by 101 · see citing works
Cell death markers in patients with cirrhosis and acute decompensation
Macdonald, S., Andreola, F., Bächtiger, P., Amorós, À., Pavesi, M., Mookerjee, R. P., Zheng, Y. B., Grønbæk, H., Gerbes, A. L., Solà, E., et al. (2017) · Hepatology · doi:10.1002/hep.29581 · Cited by 99 · see citing works
Zhai, Y., Qiao, B., GAO, F. G., Shen, X., Vardanian, A. J., Busuttil, R. W., & Kupiec‐Weglinski, J. W. (2007) · Hepatology · doi:10.1002/hep.21970 · Cited by 97 · see citing works
Woolbright, B. L., Antoine, D. J., Jenkins, R. E., Bajt, M. L., Park, B. K., & Jaeschke, H. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.09.023 · Cited by 92 · see citing works
Dhupar, R., Klune, J. R., Evankovich, J. W., Cardinal, J. S., Zhang, M. M., Ross, M., Murase, N., Geller, D. A., Billiar, T. R., & Tsung, A. (2010) · Shock · doi:10.1097/shk.0b013e3181f6aab0 · Cited by 87 · see citing works
Autophagy and acetaminophen-induced hepatotoxicity
Shan, S., Shen, Z., & Song, F. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2237-5 · Cited by 81 · see citing works
Biological Role of the N-Formyl Peptide Receptors
Panaro, M. A., Acquafredda, A., Sisto, M., Lisi, S., Maffione, A. B., & Mitolo, V. (2006) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923970600625975 · Cited by 79 · see citing works
Interferon regulatory factor 9 is a key mediator of hepatic ischemia/reperfusion injury
Wang, P., Zhang, R., Huang, L., Zhu, L., Jiang, D.-S., Chen, H., Zhang, Y., Tian, S., Zhang, X., Zhang, X.-D., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.08.022 · Cited by 77 · see citing works
Castellaneta, A., Yoshida, O., Kimura, S., Yokota, S., Geller, D. A., Murase, N., & Thomson, A. W. (2014) · Hepatology · doi:10.1002/hep.27037 · Cited by 69 · see citing works
Calmus, Y., & Poupon, R. (2014) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2014.07.007 · Cited by 69 · see citing works
Yang, M., Du, Q., Goswami, J., Varley, P. R., Chen, B., Wang, R., Morelli, A. E., Stolz, D. B., Billiar, T. R., Li, J., et al. (2017) · Hepatology · doi:10.1002/hep.29605 · Cited by 67 · see citing works
Xiao, F., Waldrop, S. L., Khimji, A.-K., & Kilic, G. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00175.2012 · Cited by 65 · see citing works
Ueki, S., Dhupar, R., Cardinal, J. S., Tsung, A., Yoshida, J., Ozaki¹, K. S., Klune, J. R., Murase, N., & Geller, D. A. (2009) · Hepatology · doi:10.1002/hep.23501 · Cited by 63 · see citing works
Therapeutic targets for cholestatic liver injury
Woolbright, B. L., & Jaeschke, H. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2016.1103735 · Cited by 54 · see citing works
Cell Death and Prognosis of Mortality in Alcoholic Hepatitis Patients Using Plasma Keratin-18
Woolbright, B. L., Bridges, B., Dunn, W., Olson, J. C., Weinman, S. A., & Jaeschke, H. (2017) · Gene Expression · doi:10.3727/105221617x15016197658871 · Cited by 48 · see citing works
IRF-1 Promotes Liver Transplant Ischemia/Reperfusion Injury via Hepatocyte IL-15/IL-15Rα Production
Yokota, S., Yoshida, O., Dou, L., Spadaro, A. V., Isse, K., Ross, M. A., Stolz, D. B., Kimura, S., Du, Q., Demetris, A. J., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402505 · Cited by 46 · see citing works
The Role of Dendritic Cells in Fibrosis Progression in Nonalcoholic Fatty Liver Disease
Almeda‐Valdés, P., Olivos, N. E. A., Barranco-Fragoso, B., Uribe, M., & Méndez‐Sánchez, N. (2015) · BioMed Research International · doi:10.1155/2015/768071 · Cited by 41 · see citing works
Sterile inflammation in acute liver injury: myth or mystery?
Woolbright, B. L., & Jaeschke, H. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1060855 · Cited by 40 · see citing works
Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury
Klune, J. R., Dhupar, R., Kimura, S., Ueki, S., Cardinal, J. S., Nakao, A., Nace, G., Evankovich, J. W., Murase, N., Tsung, A., et al. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00050.2012 · Cited by 38 · see citing works
de Araujo, A., Antunes, M. M., Mattos, M. S., Diniz, A. B., Alvarenga, D. M., Nakagaki, B. N., de Carvalho, É., Lacerda, V. A. D. S., Carvalho-Gontijo, R., Goulart, J. L. D. J., et al. (2018) · Cells · doi:10.3390/cells7080088 · Cited by 36 · see citing works
Weerasinghe, S. V. W., Ku, N., Altshuler, P. J., Kwan, R., & Omary, M. B. (2014) · Journal of Cell Science · doi:10.1242/jcs.138479 · Cited by 35 · see citing works
Xiao, F., Waldrop, S. L., Bronk, S. F., Gores, G. J., Davis, L. S., & Kilic, G. (2015) · Purinergic Signalling · doi:10.1007/s11302-015-9456-5 · Cited by 34 · see citing works
Yu, Y., Li, S., Wang, Z., He, J., Ding, Y., Zhang, H., Yu, W., Shi, Y., Cui, Z., Wang, X., et al. (2017) · Scientific Reports · doi:10.1038/srep43684 · Cited by 32 · see citing works
Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?
Handa, P., Vemulakonda, L. A., Kowdley, K. V., Uribe, M., & Méndez‐Sánchez, N. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i31.6965 · Cited by 30 · see citing works
Cui, Z., Li, S., Liu, Z., Zhang, Y., & Zhang, H. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491732 · Cited by 28 · see citing works
Gabl, M., Sundqvist, M., Holdfeldt, A., Lind, S., Mårtensson, J., Christenson, K., Marutani, T., Dahlgren, C., Mukai, H., & Forsman, H. F. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701719 · Cited by 26 · see citing works
Inzaugarat, M. E., Wree, A., & Feldstein, A. E. (2016) · Hepatology · doi:10.1002/hep.28666 · Cited by 25 · see citing works
Type I and type II interferon responses in two human liver cell lines (Huh-7 and HuH6)
Grünvogel, O., Esser‐Nobis, K., Windisch, M. P., Frese, M., Trippler, M., Bartenschlager, R. F. W., Lohmann, V., & Binder, M. (2015) · Genomics Data · doi:10.1016/j.gdata.2015.12.017 · Cited by 11 · see citing works
HMGB1 and injury amplification
Huebener, P., Hernandez, C., & Schwabe, R. F. (2015) · Oncotarget · doi:10.18632/oncotarget.5243 · Cited by 9 · see citing works
Is Keratin-18 only a marker of cell death in acute-on-chronic liver failure?
Woolbright, B. L., & Jaeschke, H. (2018) · Journal of Laboratory and Precision Medicine · doi:10.21037/jlpm.2018.03.07 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
Roehlen, N., Crouchet, E., & Baumert, T. F. (2020) · Cells · doi:10.3390/cells9040875 · Cited by 1,237 · see citing works
Denning, N., Aziz, M., Gurien, S. D., & Wang, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02536 · Cited by 630 · see citing works
Heyens, L. J. M., Busschots, D., Koek, G. H., Robaeys, G., & Francque, S. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.615978 · Cited by 243 · see citing works
Harjumäki, R., Pridgeon, C. S., & Ingelman‐Sundberg, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158221 · Cited by 237 · see citing works
Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy
Tan, Z., Sun, H., Xue, T., Gan, C., Liu, H., Xie, Y., Yao, Y., & Ye, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.730176 · Cited by 220 · see citing works
Tillman, E. J., & Rolph, T. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.601290 · Cited by 209 · see citing works
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease
Kong, L.-Z., Chandimali, N., Han, Y., Lee, D., Kim, J., Kim, S., Kim, T., Jeong, D. K., Sun, H., Lee, D. S., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112712 · Cited by 205 · see citing works
Yang, Y. M., Cho, Y. E., & Hwang, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020774 · Cited by 203 · see citing works
Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease
Ramanathan, R., Ali, A. H., & Ibdah, J. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137280 · Cited by 179 · see citing works
Mitochondrial dysfunction in nonalcoholic fatty liver disease and alcohol related liver disease
Prasun, P., Ginevic, I., & Oishi, K. (2020) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh-20-125 · Cited by 137 · see citing works
Wang, B., Huang, X., Pan, X., Zhang, T., Hou, C., Su, W., Liu, L.-L., Li, J., & Wang, Y. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.06.019 · Cited by 134 · see citing works
Hepatic Macrophages in Liver Injury
Shan, Z., & Ju, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00322 · Cited by 132 · see citing works
Danger signals in liver injury and restoration of homeostasis
Han, H., Desert, R., Das, S., Song, Z., Athavale, D., Ge, X., & Nieto, N. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.033 · Cited by 127 · see citing works
The role of cGAS-STING signalling in liver diseases
Chen, R., Du, J., Zhu, H., & Ling, Q. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100324 · Cited by 124 · see citing works
Yin, Y., Feng, W., Chen, J., Chen, X., Wang, G., Wang, S., Xu, X., Nie, Y., Fan, D., Wu, K., et al. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00539-x · Cited by 119 · see citing works
Crosstalk Between Liver Macrophages and Surrounding Cells in Nonalcoholic Steatohepatitis
Li, H., Zhou, Y., Wang, H., Zhang, M., Qiu, P., Zhang, M., Zhang, R., Zhao, Q., & Liu, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01169 · Cited by 114 · see citing works
The Role of Oxidative Stress in NAFLD–NASH–HCC Transition—Focus on NADPH Oxidases
Gabbia, D., Cannella, L., & Martin, S. D. (2021) · Biomedicines · doi:10.3390/biomedicines9060687 · Cited by 100 · see citing works
Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease
Puengel, T., Liu, H., Guillot, A., Heymann, F., Tacke, F., & Peiseler, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052668 · Cited by 95 · see citing works
Wang, M., Gauthier, A. G., Daley, L.-A., Dial, K., Wu, J., Woo, J., Lin, M., Ashby, C. R., & Mantell, L. L. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7818 · Cited by 95 · see citing works
Modulation of immune responses with nanoparticles and reduction of their immunotoxicity
Qasim, M., Jang, Y., Kang, S. H., Moon, J. J., Kim, W. J., & Park, H. (2020) · Biomaterials Science · doi:10.1039/c9bm01643k · Cited by 93 · see citing works
Wen, S., Li, X., Ling, Y., Chen, S., Deng, Q., Yang, L., Li, Y., Shen, J., Qiu, Y., Zhan, Y., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201900817r · Cited by 88 · see citing works
Lai, W., Zhang, J., Sun, J., Min, T., Bai, Y., He, J., Cao, H., Che, Q., Guo, J., & Su, Z. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134809 · Cited by 87 · see citing works
Zhou, L., Qiu, X., Meng, Z., Liu, T., Chen, Z., Zhang, P., Kuang, H., Pan, T., Lu, Y., Qi, L., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adk1866 · Cited by 81 · see citing works
Shi, S., Wang, X., van der Laan, L. J. W., Pan, Q., & Verstegen, M. M. A. (2021) · Transplantation · doi:10.1097/tp.0000000000003691 · Cited by 80 · see citing works
He, Y. Z., Li, S., Tang, D., Peng, Y., Meng, J., Peng, S., Deng, Z., Qiu, S., Liao, X., Chen, H., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.04.012 · Cited by 79 · see citing works
Dallio, M., Sangineto, M., Romeo, M., Villani, R., Romano, A. D., Loguercio, C., Serviddio, G., & Federico, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010436 · Cited by 77 · see citing works
Cerium Oxide Nanoparticles: A New Therapeutic Tool in Liver Diseases
Casals, G., Perramón, M., Casals, E., Portolés, I., Fernández‐Varo, G., Morales‐Ruiz, M., Puntes, V., & Jiménez, W. (2021) · Antioxidants · doi:10.3390/antiox10050660 · Cited by 76 · see citing works
Liver Injury and the Macrophage Issue: Molecular and Mechanistic Facts and Their Clinical Relevance
Roohani, S., & Tacke, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147249 · Cited by 76 · see citing works
De-Ritis Ratio Improves Long-Term Risk Prediction after Acute Myocardial Infarction
Steininger, M., Winter, M., Reiberger, T., Koller, L., El‐Hamid, F., Forster, S., Schnaubelt, S., Hengstenberg, C., Distelmaier, K., Goliasch, G., et al. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7120474 · Cited by 75 · see citing works
The Role of Innate Immune Cells in Nonalcoholic Fatty Liver Disease
Nati, M., Chung, K., & Chavakis, T. (2021) · Journal of Innate Immunity · doi:10.1159/000518407 · Cited by 75 · see citing works
Crosstalk between hepatic stellate cells and surrounding cells in hepatic fibrosis
Yang, F., Li, H., Li, Y., Hao, Y., Wang, C., Jia, P. P., Chen, X., Ma, S., & Xiao, Z. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108051 · Cited by 71 · see citing works
Du, Y., Lai, L., Zhang, H., Zhong, F., Cheng, H., Qian, B., Tan, P., Xia, X., & Fu, W. (2020) · Food & Function · doi:10.1039/d0fo00724b · Cited by 64 · see citing works
Liu, J., Jia, Z., & Gong, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.680648 · Cited by 63 · see citing works
Liver endothelial cells in NAFLD and transition to NASH and HCC
Velliou, R.-I., Legaki, A., Nikolakopoulou, P., Vlachogiannis, N. I., & Chatzigeorgiou, A. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04966-7 · Cited by 63 · see citing works
Alcoholic Liver Disease: Current Mechanistic Aspects with Focus on Their Clinical Relevance
Teschke, R. (2019) · Biomedicines · doi:10.3390/biomedicines7030068 · Cited by 62 · see citing works
Moayedfard, Z., Sani, F., Alizadeh, A. A., Lankarani, K. B., Zarei, M., & Azarpira, N. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02929-6 · Cited by 59 · see citing works
Regulation of neuroimmune processes by damage- and resolution-associated molecular patterns
Klegeris, A. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.293134 · Cited by 56 · see citing works
Management of hepatorenal syndrome in liver cirrhosis: a recent update
Bera, C., & Wong, F. S.-H. (2022) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848221102679 · Cited by 55 · see citing works
Macrophages as key regulators of liver health and disease
Papachristoforou, E., & Ramachandran, P. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.04.006 · Cited by 55 · see citing works
Liu, Y., Kong, X., You, Y., Xiang, L., Zhang, Y., Wu, R., Zhou, L., & Duan, L. (2022) · Cells · doi:10.3390/cells11223579 · Cited by 54 · see citing works
Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases
Rodrigues, S. G., der Merwe, V., Krag, A. A., & Wiest, R. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2023.101859 · Cited by 51 · see citing works
Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury
Zou, J., Wang, S., Wang, Y., & Wan, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105388 · Cited by 50 · see citing works
The role and mechanisms of macrophage polarization and hepatocyte pyroptosis in acute liver failure
Xie, D., & Ouyang, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1279264 · Cited by 49 · see citing works
Hazrati, A., Malekpour, K., Soudi, S., & Hashemi, S. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.865888 · Cited by 48 · see citing works
Pathophysiology of Hepatorenal Syndrome – Acute Kidney Injury
Adebayo, D., & Wong, F. S.-H. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.04.034 · Cited by 48 · see citing works
Yang, S., Kuang, G., Jiang, R., Wu, S., Zeng, T., Wang, Y., Xu, F., Xiong, L., Gong, X., & Wan, J. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.05.010 · Cited by 45 · see citing works
Immune Dysfunction and Infection Risk in Advanced Liver Disease
McGettigan, B. M., Hernández‐Tejero, M., Malhi, H., & Shah, V. H. (2025) · Gastroenterology · doi:10.1053/j.gastro.2024.08.046 · Cited by 44 · see citing works
The Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for Cancer
Gibert‐Ramos, A., Sanfeliu-Redondo, D., Aristu-Zabalza, P., Martínez-Alcocer, A., Gracia‐Sancho, J., Guixé‐Muntet, S., & Fernández‐Iglesias, A. (2021) · Cancers · doi:10.3390/cancers13225719 · Cited by 43 · see citing works
Zhou, L., Lu, Y., Qiu, X., Chen, Z., Tang, Y., Meng, Z., Yan, C., Du, H., Li, S., & Lin, J. D. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115310 · Cited by 40 · see citing works
Wan, J., Kuang, G., Zhang, L., Jiang, R., Chen, Y., He, Z., & Ye, D. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106435 · Cited by 40 · see citing works
Valade, G., Libert, N., Martinaud, C., Vicaut, É., Banzet, S., & Peltzer, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.749659 · Cited by 40 · see citing works
Advances in the study of acetaminophen-induced liver injury
Li, X., Ni, J., & Chen, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1239395 · Cited by 39 · see citing works
Resident macrophages of the lung and liver: The guardians of our tissues
Kulle, A., Thanabalasuriar, A., Cohen, T. S., & Szydlowska, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1029085 · Cited by 39 · see citing works
Li, Q., Chen, F., & Wang, F. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00921-4 · Cited by 38 · see citing works
cAMP Signaling in Pathobiology of Alcohol Associated Liver Disease
Elnagdy, M., Barve, S. S., McClain, C. J., & Gobejishvili, L. (2020) · Biomolecules · doi:10.3390/biom10101433 · Cited by 38 · see citing works
Zhou, J., Guo, L., Ma, T., Qiu, T., Wang, S., Tian, S., Zhang, L., Hu, F., Li, W., Liu, Z., et al. (2021) · Hepatology · doi:10.1002/hep.32202 · Cited by 37 · see citing works
Necroptosis in Hepatosteatotic Ischaemia-Reperfusion Injury
Baidya, R., Crawford, D. H., Gautheron, J., Wang, H., & Bridle, K. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165931 · Cited by 36 · see citing works
Wang, J.-C., Shi, Q., Zhou, Q., Zhang, L.-L., Qiu, Y.-P., Lou, D.-Y., Zhou, L.-Q., Yang, B., He, Q.-J., Weng, Q.-J., et al. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00842-x · Cited by 36 · see citing works
Sun, M., Chen, P., Xiao, K., Zhu, X., Zhao, Z., Guo, C., He, X., Shi, T., Zhong, Q., Jia, Y., et al. (2023) · Advanced Science · doi:10.1002/advs.202206789 · Cited by 36 · see citing works
Release of damaged mitochondrial DNA: A novel factor in stimulating inflammatory response
Li, W., Li, Y., Zhao, J., Liao, J., Wen, W., Chen, Y., & Cui, H. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155330 · Cited by 34 · see citing works
Vargas-Pozada, E. E., Ramos‐Tovar, E., Acero-Hernández, C., Cardoso-Lezama, I., Galindo‐Gómez, S., Tsutsumi, V., & Muriel, P. (2022) · Annals of Hepatology · doi:10.1016/j.aohep.2022.100671 · Cited by 34 · see citing works
NADPH Oxidase Inhibition in Fibrotic Pathologies
Bernard, K. F., & Thannickal, V. J. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8032 · Cited by 33 · see citing works
Kamel, G. A. M., Harahsheh, E., & Hussein, S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07366-5 · Cited by 33 · see citing works
Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review)
Li, R., Wu, H., Xu, Y., Xu, X., Xu, Y., Huang, H., Lv, X., Liao, C., Ye, J., & Li, H. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13471 · Cited by 32 · see citing works
GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis
Chen, Y., Xu, Y.-N., Ye, C.-Y., Feng, W., Zhou, Q., Yang, D., & Wang, M. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00836-9 · Cited by 32 · see citing works
Papendorf, J. J., Krüger, E., & Ebstein, F. (2022) · Cells · doi:10.3390/cells11091422 · Cited by 32 · see citing works
Immunomodulatory role of mitochondrial DAMPs: a missing link in pathology?
Garg, M., Johri, S., & Chakraborty, K. (2022) · FEBS Journal · doi:10.1111/febs.16563 · Cited by 32 · see citing works
Innate immunity and early liver inflammation
Zhou, J. Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1175147 · Cited by 32 · see citing works
Li, M., Wu, C., Guo, H., Chu, C., Hu, M., & Zhou, C. (2019) · Food & Function · doi:10.1039/c9fo00153k · Cited by 32 · see citing works
Madir, A., Grgurević, I., Tsochatzis, E. A., & Pinzani, M. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i4.290 · Cited by 31 · see citing works
Purinergic signaling in hepatic disease
Velázquez‐Miranda, E., Díaz‐Muñoz, M., & Vázquez‐Cuevas, F. G. (2019) · Purinergic Signalling · doi:10.1007/s11302-019-09680-3 · Cited by 31 · see citing works
Zhang, C., Lin, J., Chao, Z., Wang, F., Sun, X., Kong, X., & Gao, Y. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.03.011 · Cited by 31 · see citing works
The dual function of cGAS-STING signaling axis in liver diseases
Li, X., Qu, J., Zhang, Y.-H., & Liu, R. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01220-5 · Cited by 28 · see citing works
Tourkochristou, E., Mouzaki, Α., & Triantos, C. K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098288 · Cited by 28 · see citing works
Chiabotto, G., Pasquino, C., Camussi, G., & Bruno, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.594794 · Cited by 27 · see citing works
Meirelles, L. D. S., Marson, R. F., Solari, M. I. G., & Nardi, N. B. (2020) · Cells · doi:10.3390/cells9010188 · Cited by 26 · see citing works
Chen, S., Guo, H., Xie, M., Zhou, C., & Zheng, M. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107609 · Cited by 25 · see citing works
Cai, S., Fan, X., Wu, J., Wang, Y., Hu, X., Pei, S., Zheng, Y., Chen, J., Huang, Y., Li, N., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-01037-8 · Cited by 25 · see citing works
Mohammed, S., Thadathil, N., Tran, A. L., Veldt, M. V. D., Georgescu, C., Nair, H. H., Oh, S., Oh, S., Nicklas, E. H., Wang, D., et al. (2023) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-22-0820 · Cited by 25 · see citing works
Zhang, Q., Wu, S., Chen, Q., Zhang, Y., Zhang, C., Yin, R., Ouyang, Z., & Wei, Y. (2024) · Biomedicines · doi:10.3390/biomedicines12071505 · Cited by 25 · see citing works
Unveiling the flames: macrophage pyroptosis and its crucial role in liver diseases
Ni, L., Chen, D., Zhao, Y., Ye, R., & Fang, P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1338125 · Cited by 24 · see citing works
Zhang, C., Chen, F., Li, F., Shan, Q., Zheng, G., Wang, Y., Lu, J. L., Fan, S., Sun, C., Wu, D., et al. (2019) · Molecular Medicine · doi:10.1186/s10020-019-0099-9 · Cited by 24 · see citing works
Borjas, T., Jacob, A., Yen, H.-T., Patel, V. M., Coppa, G. F., Aziz, M., & Wang, P. (2021) · Shock · doi:10.1097/shk.0000000000001894 · Cited by 23 · see citing works
Pathogenesis from Inflammation to Cancer in NASH-Derived HCC
Yu, S., Wang, J., Zheng, H., Wang, R., Johnson, N. L., Li, T., Li, P., Lin, J., Li, Y., Jin, Y., et al. (2022) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s377768 · Cited by 23 · see citing works
Jung, J., Suh, C., & Kim, H. (2019) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2019.1615449 · Cited by 23 · see citing works
Zhang, N., Han, L., Xue, Y., Deng, Q., Wu, Z., Peng, H., Zhang, Y., Xuan, L., Pan, G., & Fu, Q. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00620 · Cited by 23 · see citing works
Gao, Y., Li, Z., Jin, L., Lin, J., Fan, Z.-L., Zeng, Z., & Huang, H. (2021) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2021.04.001 · Cited by 22 · see citing works
Acute kidney injury: prediction, prognostication and optimisation for liver transplant
Jagarlamudi, N., & Wong, F. S.-H. (2020) · Hepatology International · doi:10.1007/s12072-020-10018-0 · Cited by 22 · see citing works
Liu, C., Huang, X., Kong, J., Li, X., Wang, Y., Zhang, F., & Duan, J. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117441 · Cited by 21 · see citing works
Sterile inflammation in MASH: emerging role of extracellular RNA and therapeutic strategies
Raza, S., Mahamood, R., Medhe, P., Shahi, A., Yadav, A., Tewari, A., & Sinha, R. A. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00083-0 · Cited by 21 · see citing works
Immune and Metabolic Alterations in Liver Fibrosis: A Disruption of Oxygen Homeostasis?
Li, X., Zhang, Q., Wang, Z., Zhuang, Q., & Zhao, M. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.802251 · Cited by 21 · see citing works
Han, D., Xu, K., Jin, Z., Xu, Y., Li, Y., Wang, L., Cao, Q., Kim, K.-P., Ryu, D. H., Hong, K., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85145 · Cited by 21 · see citing works
New Biomarkers in Liver Fibrosis: A Pass through the Quicksand?
Tagliaferro, M., Marino, M., Basile, V., Pocino, K., Rapaccini, G. L., Ciasca, G., Basile, U., & Carnazzo, V. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14080798 · Cited by 20 · see citing works
The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39
Xia, G., Cai, J.-N., Wu, X., Fang, Q., Zhao, N. O., & Lv, X. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174729 · Cited by 19 · see citing works
STING‐mediated inflammation contributes to Gao binge ethanol feeding model
Wang, L., You, H., Meng, H., Pan, X., Chen, X., Bi, Y., Zhang, Y., Li, J., Yin, N., Zhang, Z., et al. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30606 · Cited by 18 · see citing works
Zhao, J., Ghallab, A., Hassan, R. A. R. A., Dooley, S., Hengstler, J. G., & Drasdo, D. (2023) · iScience · doi:10.1016/j.isci.2023.108077 · Cited by 18 · see citing works
Peroxiredoxin-1 aggravates lipopolysaccharide-induced septic shock via promoting inflammation
He, Y. Z., Peng, Y., Tao, L., Peng, Z., & Yang, H. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.04.149 · Cited by 18 · see citing works
The role of the gut microbiome in graft fibrosis after pediatric liver transplantation
Qin, T., Fu, J., & Verkade, H. J. (2020) · Human Genetics · doi:10.1007/s00439-020-02221-8 · Cited by 18 · see citing works
Jiangqiao, Z., Tianyu, W., Chen, Z., Zhang, L., Jilin, Z., Ma, X., & Tao, Q. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.506275 · Cited by 18 · see citing works
Belcher, J. M. (2023) · Medical Clinics of North America · doi:10.1016/j.mcna.2023.03.009 · Cited by 17 · see citing works
- Authors
- Mihm, S.
- Affiliations
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Mihm, Sabine
- ORCID
- Mihm, Sabine
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-10-10
- Volume
- 19
- Issue
- 10
- Pages
- 3104
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6213769
- OpenAlex
- W2896394478
- Cited by
- 232
- References
- 123
- Citations by year
- 2026: 27 · 2025: 30 · 2024: 32 · 2023: 35 · 2022: 34 · 2021: 25 · 2020: 32 · 2019: 16 · 2018: 1
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- damage-associated molecular patterns, sterile inflammation, liver inflammation, liver necrosis, apoptosis, Kupffer cells, monocytes, neutrophils, type I interferon, nonalcoholic steatohepatitis, alcoholic liver disease, cholestatic liver injury, hepatic ischemia-reperfusion injury, innate immune recognition
- MeSH terms
- Alarmins, Pathogen-Associated Molecular Pattern Molecules, Adenosine Triphosphate, Animals, Hepatitis, Humans, Keratins, Mitochondria, Liver, Biomarkers, HMGB1 Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
