Cited by 285Inflammatory Bowel DiseaseGut microbiota and healthMicroscopic Colitis

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Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS): a randomised, double-blind, placebo-controlled trial

Haifer, Craig, Paramsothy, Sudarshan, Kaakoush, Nadeem O, Saikal, Aiasha, Ghaly, Simon, Yang, Tao, Luu, Laurence Don Wai, Borody, Thomas J, Leong, Rupert W·2022·The Lancet Gastroenterology & Hepatology

DOI 10.1016/s2468-1253(21)00400-3

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Abstract

Background Faecal microbiota transplantation (FMT) delivered via colonoscopic infusion or enemas have been shown to induce remission in a proportion of patients with active ulcerative colitis. Whether orally administered FMT is effective in ulcerative colitis is unknown. We aimed to assess the efficacy of oral lyophilised FMT for the treatment of active ulcerative colitis. Methods A double-blind, randomised, placebo-controlled trial was conducted at two centres in Australia. Eligible patients were aged 18-75 years with active ulcerative colitis (defined as clinical and endoscopic active ulcerative colitis, with a total Mayo score of 4-10, and a Mayo endoscopic subscore ≥1). After 2 weeks of amoxicillin, metronidazole, and doxycycline, patients were randomly assigned in a 1:1 ratio to receive either oral lyophilised FMT or placebo capsules for 8 weeks, using a prespecified computer-generated randomisation list with a permuted block size of 8. The primary outcome was corticosteroid-free clinical remission with endoscopic remission or response (total Mayo score ≤2, all subscores ≤1, and ≥1 point reduction in endoscopic subscore) at week 8. At week 8, FMT responders were randomly assigned (in a 1:1 ratio, permuted block size of 8) to either continue or withdraw FMT for a further 48 weeks. Analyses were done by modified intention-to-treat, including all patients who received at least one study dose. This trial is registered with Australian New Zealand Trial Registry, number ACTRN…

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Knights, D., Kuczynski, J., Charlson, E. S., Zaneveld, J., Mozer, M. C., Collman, R. G., Bushman, F. D., Knight, R. D., & Kelley, S. T. (2011) · Nature Methods · doi:10.1038/nmeth.1650 · Cited by 1,876
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Potential role of gut microbiota and its metabolites in radiation-induced intestinal damage
Xin, J., Wang, J., Ding, Q., Chen, W., Xu, X., Wei, X., Lv, Y.-H., Wei, Y., Feng, Y., & Zu, X. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114341 · Cited by 32
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Immunometabolism and microbial metabolites at the gut barrier: Lessons for therapeutic intervention in inflammatory bowel disease
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Causal role of the gut microbiome in certain human diseases: a narrative review
Prosty, C. J., Katergi, K., Papenburg, J., Lawandi, A., Lee, T. C., Shi, H., Burnham, P., Swem, L. R., Routy, B., Yansouni, C. P., et al. (2024) · eGastroenterology · doi:10.1136/egastro-2024-100086 · Cited by 22
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Lu, G., Zhang, S., Wang, R., Wu, X., Chen, Y., Wen, Q., Cui, B., Zhang, F., & Li, P. (2025) · BMC Medicine · doi:10.1186/s12916-025-04353-y · Cited by 21
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Authors: Haifer, C., Paramsothy, S., Kaakoush, N. O., Saikal, A., Ghaly, S., Yang, T., Luu, L. D. W., Borody, T. J., & Leong, R. W.
Affiliations: The University of Sydney (AU)
UNSW Sydney (AU)
Centre For Digestive Diseases (AU)
Corresponding author: Leong, Rupert W
ORCID: Haifer, Craig
Paramsothy, Sudarshan
Kaakoush, Nadeem O
Ghaly, Simon
Yang, Tao
Luu, Laurence Don Wai
Borody, Thomas J
Leong, Rupert W
Venue: The Lancet Gastroenterology & Hepatology
Publisher: Elsevier BV
Published: 2022-02
Volume: 7
Issue: 2
Pages: 141-151
ISSN: 2468-1156 (ISSN-L)
2468-1253
DOI: 10.1016/s2468-1253(21)00400-3
OpenAlex: W3215433280
Cited by: 285
References: 30
Citations by year: 2026: 45 · 2025: 79 · 2024: 60 · 2023: 68 · 2022: 32
FWCI: 22.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: The Lancet. Gastroenterology & hepatology (publishedVersion)
PubMed (publishedVersion)
Funders: Gastroenterological Society of Australia
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
Keywords: fecal microbiota transplantation, ulcerative colitis, corticosteroid-free remission, endoscopic remission, treatment withdrawal, COVID-19 pandemic, inflammatory bowel disease, antibiotic pretreatment, clinical remission, endoscopic response, safety and tolerability
MeSH terms: Fecal Microbiota Transplantation, Administration, Oral, Adult, Anti-Bacterial Agents, Colitis, Ulcerative, Double-Blind Method, Female, Freeze Drying, Humans, Male, Middle Aged, Remission Induction

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Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS): a randomised, double-blind, placebo-controlled trial

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