Systematic review of donor and recipient predictive biomarkers of response to faecal microbiota transplantation in patients with ulcerative colitis
Open accessAbstract
BACKGROUND: Faecal microbiota transplantation (FMT) has previously been explored as a treatment for ulcerative colitis (UC) however, biomarkers that predict and / or are associated with clinical response are poorly defined. The aim of this systematic review was to identify donor and recipient clinical, microbial and metabolomic predictive biomarkers of response to FMT in UC. METHODS: A systematic search of the relevant literature of studies exploring FMT in UC was conducted. Data on microbial diversity, taxonomic changes, metabolic changes, donor and recipient microbiota relationship and baseline predictors was examined. FINDINGS: 2852 studies were screened, and 25 papers were included in this systematic review. Following FMT, alpha diversity was seen to increase in responders along with increases in the abundance of Clostridiales clusters (order) and Bacteroides genus. Metabolomic analysis revealed short chain fatty acid (SCFA) production as a marker of FMT success. Donors or FMT batches with higher microbial alpha diversity and a greater abundance of taxa belonging to certain Bacteroides and Clostridia clusters were associated with clinical response to FMT. Baseline clinical predictors of response in patients with UC included younger age, less severe disease and possibly shorter disease duration. Baseline recipient microbial predictors at response consisted of higher faecal species richness, greater abundance of Candida and donor microbial profile similarity. INTERPRETATION: Distinct changes in gut microbiota profiles post-FMT indicate that certain baseline characteristics along with specific microbial and metabolomic alterations may predispose patients towards a successful therapeutic outcome. Opportunities towards a biomarker led precision medicine approach with FMT should be explored in future clinical studies. FUNDING: There no specific funding to declare.
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Higher donor alpha diversity was identified as predictive of a response in a systematic review of 25 studies evaluating FMT in patients with UC.
“More extensively, higher donor alpha diversity was identified as predictive of a response in a systematic review of 25 studies evaluating FMT in patients with UC. 57”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [57]
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Flagged first, then by citations
Research works printed but not linked: 2
- [19]Sarbagili Shabat C Scaldaferri F Zittan E Use of Fecal transplantation with a novel diet for mild to moderate active ulcerative colitis: The CRAFT UC randomized controlled trial J Crohns Colitis 2021 PMC8919830 34514495
- [28]Sood A Singh A Mahajan R Clinical Predictors of response to Faecal Microbiota Transplantation in patients with active ulcerative colitis J Crohns Colitis 2020 32772093
- Authors
- Rees, N. P., Shaheen, W., Quince, C., Tselepis, C., Horniblow, R. D., Sharma, N., Beggs, A. D., Iqbal, T. H., & Quraishi, M. N.
- Affiliations
- University of Birmingham (GB)
- Earlham Institute (GB)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Corresponding author
- Quraishi, Mohammed Nabil
- ORCID
- Venue
- EBioMedicine
- Publisher
- Elsevier BV
- Published
- 2022-07
- Volume
- 81
- Pages
- 104088
- ISSN
- 2352-3964 (ISSN-L)
- PMC
- PMC9163485
- OpenAlex
- W4281689359
- Cited by
- 73
- References
- 52
- Citations by year
- 2026: 12 · 2025: 28 · 2024: 17 · 2023: 15 · 2022: 1
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- EBioMedicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, cc-by)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Funders
- Engineering and Physical Sciences Research Council (EP/V027743/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- fecal microbiota transplantation, ulcerative colitis, predictive biomarkers, treatment response, gut microbiota, microbial diversity, short-chain fatty acids, Bacteroides, Clostridiales, Candida, metabolomics, precision medicine
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Colitis, Ulcerative, Feces, Humans, Biomarkers, Treatment Outcome
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